N Bouzari; AR Firooz; H Tabatabai; Y Dowlati
Volume 4, Issue 3 , 2001, , Pages 24-29
Abstract
Background: Minoxidil is currently an approved treatment for androgenetic alopecia. Topical tretinoin can enhance skin absorption of minoxidil. Objective: This study has been done in order to determine the efficacy and safety of the solution of 0.5% minoxidil+0.05% tretinoin compared to 2% minoxidil ...
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Background: Minoxidil is currently an approved treatment for androgenetic alopecia. Topical tretinoin can enhance skin absorption of minoxidil. Objective: This study has been done in order to determine the efficacy and safety of the solution of 0.5% minoxidil+0.05% tretinoin compared to 2% minoxidil in androgenetic alopecia in men. Patients and Methods: In a randomized, double-blind, parallel-group, controlled study, 117 male patients with androgenetic alopecia, 18-40 years old, Hamilton grades of 2-5 and duration of alopecia less than 10 years were evaluated. These patients were divided in two groups randomly, one group received a solution containing 0.5% minoxidil and 0.05% tretinoin and another group received 2% minoxidil for at least 4 months. The patients used 1ml of the solution twice daily. 2 and 4 months after treatment, the patients were evaluated for efficacy (Patients, idea about improvement of hair loss, hair regrowth and wash test) and safety (Erythema, scaling and pruritus). The quantitative data were analyzed by ANOVA and the qualitative data were analyzed by qui-squared test. Results: There were no significant differences between two groups regarding the age, duration and grade of hair loss. After 4 months of treatment, the percentage of patients reporting improvement in hair loss and hair regrowth were 81.6% and 56% in minoxidil 2% group and 65.4% and 59.6% in minoxidil+tretinoin group, respectively (P>0.05 for all). At the same time, the numbers of hairs in wash test were 156 in minoxidil 2% group and 149 in minoxidil+tretinoin group (P>0.05). Conclusion: There was no significant difference in efficacy and safety of 4 months treatment with the solution of 0.5% minoxidil and 0.05% tretinoin compared to the solution of 2% minoxidil in the treatment of androgenetic alopecia in men.
H Tabatabai; M Heydari Seradj
Volume 4, Issue 1 , 2000, , Pages 36-50
Abstract
Dapsone first came into medicine as an antibacterial agent but was found to be less effective than other sulfonamides. Likewise its activity against tuberculosis was disappointing. Nevertheless, it has been the main stay in the treatment of leprosy. It also has some action against malaria and other parasites. ...
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Dapsone first came into medicine as an antibacterial agent but was found to be less effective than other sulfonamides. Likewise its activity against tuberculosis was disappointing. Nevertheless, it has been the main stay in the treatment of leprosy. It also has some action against malaria and other parasites. Nowadays, after leprosy, dapsone has proved as a valuable drug in the treatment of a wide range of mainly uncommon and rare dermatoses. In this article, we present a comprehensive review of the mechanisms of action, pharmacokinetics, uses, adverse reactions and management of side effects of dapsone.
H Tabatabai
Volume 3, Issue 1 , 1999, , Pages 52-57
Abstract
Leprosy is a chronic infectious disease endemic in Iran that mainly involves skin and peripheral nerves. Leprosy has several clinical forms. One of them is “Pure neural leprosy”. The diagnosis of this form is delayed due to lack of clinical signs in other tissues and can lead to permanent ...
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Leprosy is a chronic infectious disease endemic in Iran that mainly involves skin and peripheral nerves. Leprosy has several clinical forms. One of them is “Pure neural leprosy”. The diagnosis of this form is delayed due to lack of clinical signs in other tissues and can lead to permanent deformity. I will discuss my experience for 20 years in the diagnosis and treatment of this form of leprosy and will report a case. Definite diagnosis is usually possible by biopsy of an involved peripheral nerve. Biopsy from uninvolved nerve might give inconclusive results (Sometimes biopsy is taken only from sural nerve) but typical changes of neural leprosy can be found in involved nerves in the same patient. Nerve biopsy can also help in the classification of leprosy and differentiation of leprotic neuritis from neuritis in leprosy reactions. The main complication of nerve biopsy is a local anesthesia of the skin, which usually improves spontaneously. Considering the absence of neurosurgeons in most endemic areas of leprosy, it is recommended to train physicians involved in leprosy treatment to do nerve biopsy.
H Tabatabai; Z Haji Abbasi
Volume 1, 3-4 , 1998, , Pages 12-22
Abstract
Thalidomide, a hypnosedative drug introduced in the 1950, has been used in a variety of dermatologic conditions during the past few decades. Although originally withbrawn from world market on discovery of its teratogenic effect, it has since been selectively reintroduced for use in various disorders ...
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Thalidomide, a hypnosedative drug introduced in the 1950, has been used in a variety of dermatologic conditions during the past few decades. Although originally withbrawn from world market on discovery of its teratogenic effect, it has since been selectively reintroduced for use in various disorders thought to have an autoimmune or inflammatory basis. A review of the literature focused on clinical uses of thalidomide in the treatment of dermatologic diseases was performed. Diseases for which thalidomide has been found effective include erythema nodosum leprosum, prurigo nodularis, actinic prurigo, discoid lupus erythematosus, aphthous stomatitis, Behcet’s syndrome, and graft versus-host disease. Side effects such as teratogenicity and peripheral neuropathy remain its limiting factors. Thalidomide is a useful addition to the therapeutic armamentarium for treatment-resistant dermatoses as long as proper vigilance for adverse effects is maintained.