Nahidi Yalda; Layegh Pouran; Naser Tayyebi Meibodi; Vida Vakili; Golsan Kardan
Abstract
Background: Vitiligo is a pigmentation disorder of the skin characterized by the loss of melanocytes through different mechanisms. Narrow band UVB (NBUVB) is a safe and effective treatment for vitiligo that acts by inducing the synthesis of cytokines involved in melanogenesis. NBUVB appears to be involved ...
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Background: Vitiligo is a pigmentation disorder of the skin characterized by the loss of melanocytes through different mechanisms. Narrow band UVB (NBUVB) is a safe and effective treatment for vitiligo that acts by inducing the synthesis of cytokines involved in melanogenesis. NBUVB appears to be involved in the treatment of vitiligo by increasing the synthesis of vitamin D, which prevents the apoptosis of melanocytes; accordingly, we set out to compare the serum level of vitamin D and its variations following NBUVB treatment according to the degree of response to treatment.
Methods: Thirty-eight patients with vitiligo were subject to phototherapy with NBUVB. Photographs of vitiligo lesions were taken prior to and after completing 60 phototherapy sessions. Further measured were the serum level of 25-hydroxyvitamin D3, VASI score and repigmentation rate before and after the treatment period. Finally, the relationship between the changes in serum vit D3 levels and variations of VASI score was investigated.
Results: Mean serum level of vitamin D3 was 20.78 ng/ml after treatment, which is significantly more compared to the period before the treatment (15.42, P=0.001). Mean VASI score was 5.45 before the treatment, yet was reduced to 2.24 after treatment, which is a significant change (P<0.001); however, the changes in vitamin D3 levels were not significantly correlated with VASI score (P=0.137).
Conclusion: The repigmentation rate in vitiligo lesions are not significantly correlated with serum vitamin D3 levels. Therefore, NBUVB is not likely to improve vitiligo lesions through the increase in serum vitamin D levels.
Banihashemi Mahnaz; Nahidi Yalda; Meibodi Naser Tayyebi; Jarrahi Lida; Livani Fatemeh; Seifnia Sahar
Abstract
Background: Pemphigus vulgaris (PV) is a rare autoimmune blistering disease of the skin and mucous membranes. Because vitamin D deficiency is associated with many immune disorders, we compared the levels of vitamin D between PV patients and healthy controls. Methods: Vitamin D level of 20 patients with ...
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Background: Pemphigus vulgaris (PV) is a rare autoimmune blistering disease of the skin and mucous membranes. Because vitamin D deficiency is associated with many immune disorders, we compared the levels of vitamin D between PV patients and healthy controls. Methods: Vitamin D level of 20 patients with PV was compared with 20 healthy individuals matched for age, gender, hours spent in the sun, body mass index (BMI) and daily vitamin D intake at the same time interval. The severity of the disease was estimated according to ABSIS score. The serum level of 25-hydroxyvitamin D (25OHD) was measured by a commercial ELISA test. Results: Vitamin D deficiency in the pemphigus vulgaris group (75%) was higher than healthy controls (45%) (P = 0.053). Mean level of vitamin D in PV patients was significantly lower than healthy controls, and was in the range of vitamin deficiency (P ? 0.05). No significant relationship was observed between the severity of the PV disease and vitamin D levels (P > 0.05). Conclusions: Based on the results of the present study, the mean level of vitamin D in patients with PV was significantly lower than healthy people. Based on our findings and given the important role of vitamin D in preventing inflammatory and autoimmune diseases, vitamin D deficiency can be considered as a factor triggering the onset of PV.
Nahidi Yalda; Meibodi Naser Tayyebi; Ghazvini Kiarash; Esmaeeli Habiballah; Nahidi Mahsa
Volume 18, Issue 4 , 2015, , Pages 163-168
Abstract
Background: Mycosis fungoides is the most common type of primary cutaneous T-cell lymphoma. Its etiopathogenesis, despite numerous studies, remains unclear. Environmental, viral, and genetic factors have been proposed as its potential etiologic factors. In recent years, viral agents of herpes virus family ...
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Background: Mycosis fungoides is the most common type of primary cutaneous T-cell lymphoma. Its etiopathogenesis, despite numerous studies, remains unclear. Environmental, viral, and genetic factors have been proposed as its potential etiologic factors. In recent years, viral agents of herpes virus family such as human herpes virus 8 (HHV-8) have been noticed.Objective: The aim of this study was to evaluate the association between the presence of HHV-8 and mycosis fungoides.Methods: This case-control study was done on skin biopsies of 42 mycosis fungoides cases referred to the Department of Pathology, Imam Reza Hospital, Mashhad, Iran from 2004 to2012, and 42 age and sex matched samples of melanocytic nevi. PCR was performed to detect HHV-8 in biopsy samples of the patients and the control group. Statistical analysis was done using the IBM SPSS Statistics (IBM Corp., Armonk, NY, USA) 20.Results: Of 42 patients with MF, 25 were male and 17 were female with a male to female ratio of 1.4. The mean age of the patients was 51.2 years. Most of the patients were in the age group over 60 years. Clinical lesions of the majority of the patients were papules and plaques. HHV-8 DNA was not found in any of the mycosis fungoides samples using the PCR method.Conclusion: Based on our study results, HHV-8 does not play an important role in the pathogenesis of mycosis fungoides.
Taheri Ahmad Reza; Farmanbar Mohammad Ali; Kiafar Bita; Khajedaluee Mohammad; Javidi Zari; Nahidi Yalda; Maleki Masoud
Volume 17, Issue 1 , 2014, , Pages 1-7
Abstract
Background: The standard patch test is known as the most reliable test to identify and confirm causative agents of allergic contact dermatitis (ACD). Previous studies have shown that the prevalence of specific allergens varies by geographic area. The results of patch test in patients visiting our dermatology ...
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Background: The standard patch test is known as the most reliable test to identify and confirm causative agents of allergic contact dermatitis (ACD). Previous studies have shown that the prevalence of specific allergens varies by geographic area. The results of patch test in patients visiting our dermatology clinics with suspected ACD were prospectively investigated and compared with those reported in the literature of Iran.Method: We performed the European Standard Series patch test produced by Almiral Hermal GmbH, containing 28 allergens in a group of 100 patients (55 females and 45 males) with suspected ACD who were referred to Emam Reza and Ghaem Hospitals, Mashhad, in 2010-2011. The tests were read after 2 and 4 days.Result: Fifty-four percent of the patients had 1 or more positive reactions of which 65% were relevant to current or past dermatitis. Positive reactions were due to 12 allergens. The most frequent allergens were nickel sulfate (25%) and potassium
Layegh Pouran; Meibodi Naser Tayyebi; Nahidi Yalda; Sepehri Zahra; Nazari Ali; Shakeri Mohammad Taghi
Volume 17, Issue 1 , 2014, , Pages 8-12
Abstract
Background: The description on patients with pigmented back patches is rarely reported in the literature. We decided to study the clinicopathological aspects of these patients for reaching a better understanding of this disease.Method: In this study, the clinicopathological aspects and probable responsible ...
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Background: The description on patients with pigmented back patches is rarely reported in the literature. We decided to study the clinicopathological aspects of these patients for reaching a better understanding of this disease.Method: In this study, the clinicopathological aspects and probable responsible factors in the manifestation of posterior pruritic pigmented patches in patients referred to the dermatology clinic of Qaem University Hospital from October 2007 to September 2009 were surveyed.Result: All 60 patients who were enrolled in our study were female with a mean age of 31.43±9.71 years. Six patients did not consent to biopsy. The most c
Layegh Pouran; Nahidi Yalda; Malekzadeh Iman; Shakeri Mohammad Taghi
Volume 16, Issue 3 , 2013, , Pages 100-104
Abstract
Background: Pemphigus is a rare autoimmune disease causedby autoantibodies against desmoglein. It clinically presents withpainful blisters and erosions on the skin and mucous membranes.Few studies have been conducted on the quality of life inpemphigus patients which have all indicated the strong impactof ...
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Background: Pemphigus is a rare autoimmune disease causedby autoantibodies against desmoglein. It clinically presents withpainful blisters and erosions on the skin and mucous membranes.Few studies have been conducted on the quality of life inpemphigus patients which have all indicated the strong impactof the disease on emotional and physical status of the patients.According to evident differences in the culture and quality oflife between our society and western societies, we assessed thequality of life in patients with pemphigus in the Northeast of Iran.Method: This study was conducted on 78 pemphigus vulgarispatients who were visited or hospitalized in the dermatologyclinics of Qaem and Imam Reza Hospitals in Mashhad, Iran.Data collection was done by the Dermatology Life Quality Index(DLQI) questionnaire in patients with pemphigus vulgaris.Statistical analysis was performed using SPSS 11.5 software withChi-square, T-test and ANOVA statistical tests.Result: The disease had a significant impact on the quality oflife in the majority of patients (31 (39.7%) patients). Hospitalizedand newly diagnosed cases and those receiving higher doses ofsteroid had lower quality of life. The patient’s age, sex, educationlevel, and therapeutic regimen did not have a significant effecton the quality of life.Conclusion: Pemphigus is not just a physical disease and hasvarious aspects. It is responsible for many changes in healthrelatedquality of life in patients. Therefore, we will be successfulin treating this disease only when psychological and social aspectsof pemphigus are considered in addition to clinical improvementof the patients.
Nahidi Yalda; Meibodi Naser Tayyebi; Layegh Pouran; Esmaeeli Habiballah; Hosseini Fatemeh Sadat
Volume 16, Issue 2 , 2013, , Pages 57-63
Abstract
Background: Melasma is a common acquired hyperpigmentationdisorder often appearing on the face of young women. Melasmais classified into four groups based on Wood’s lamp examination:epidermal, dermal, mixed, and indeterminate. The goal of this studywas to evaluate the relationship between clinicoepidemiologicalcharacteristics ...
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Background: Melasma is a common acquired hyperpigmentationdisorder often appearing on the face of young women. Melasmais classified into four groups based on Wood’s lamp examination:epidermal, dermal, mixed, and indeterminate. The goal of this studywas to evaluate the relationship between clinicoepidemiologicalcharacteristics of melasma and the level of involvement underWood’s lamp examination.Method: In a cross sectional study, 50 melasma patients whowere visited at the dermatology clinic of Imam Reza Hospitalfrom March 2010 to September 2011 were studied. The levelof melasma involvement in all patients was determined usinga Wood’s lamp, and the patients’ information such as age,occupation, location of melasma, marital status, pregnancy, oralcontraceptive pill consumption and Fitzpatrick skin type wascollected in a questionnaire.Result: In single patients, dermal involvement and in marriedpatients, epidermal involvement was more common. Involvementwas more frequently dermal in jobs with exposure to sun andmore epidermal in indoor jobs. In the malar region, epidermalinvolvement was more common. In patients with a history ofpregnancy, epidermal involvement was more prevalent as well,while in the participants without a history of pregnancy, dermalinvolvement was more frequent. In the pregnant patients withmelasma, epidermal involvement was more frequent. In patientswithout a family history of melasma, epidermal involvement wasmore frequently observed than the other two levels of involvement.Conclusion: Based on the findings of this study, melasma in caseswith the involvement of the malar region, starting in pregnancy,in patients without a family history of melasma, and in theindividuals who have indoor occupations is most likely to beepidermal and may have a better response to treatment. On theother hand, melasma in single persons and in those who haveoutdoor occupations and are exposed to sun light is mostly dermalwith a worse response to treatment according to previous studies.
Maleki Masoud; Farhat Ahmad-Shah; Nahidi Yalda; Herizadeh Nafiseh-Sadat; Ahrani Saeedeh
Volume 16, Issue 2 , 2013, , Pages 64-68
Abstract
Background: Birthmarks are common reasons for parents’ concern.Some of them may need further investigation to find out theunderlying systemic disorders or their potential for malignanttransformation. The purpose of this study was to determine thefrequency of vascular and pigmented birthmarks in ...
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Background: Birthmarks are common reasons for parents’ concern.Some of them may need further investigation to find out theunderlying systemic disorders or their potential for malignanttransformation. The purpose of this study was to determine thefrequency of vascular and pigmented birthmarks in infants fromthe Northeast of Iran.Method: This descriptive study was conducted on 1000 healthyinfants born in a University Hospital in the Northeast of Iran from2003 to 2005. The cutaneous lesions of neonates were examinedby a dermatologist.Result: The salmon patch was reported as the most commonbirthmark (233 cases). The most common site of involvementwas the eyelid. A case of congenital hemangioma and a case ofthe port-wine stain were also observed both in the fifth n
Nahidi Yalda; Javidi Zari; Shakeri Mohammad Taghi; Farrokhnezhad Somayyeh
Volume 15, Issue 3 , 2012, , Pages 80-84
Abstract
Introduction: Acne is a common problem in adolescent and youngage groups, for which several risk factors have been suggested.One of the risk factors is smoking. In studies on the relationshipbetween smoking and acne, conflicting results have been obtained.Method: This study was conducted on 133 male ...
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Introduction: Acne is a common problem in adolescent and youngage groups, for which several risk factors have been suggested.One of the risk factors is smoking. In studies on the relationshipbetween smoking and acne, conflicting results have been obtained.Method: This study was conducted on 133 male patients whowere visited at the dermatology clinic of Imam Reza hospital dueto acne as the case group, and 133 healthy individuals withoutany skin diseases including acne among those accompanying thepatients as the control group. The case and the control groups wereage matched. For each patient who had the criteria for inclusionin the study, a questionnaire was completed and the necessaryinformation was collected and then analyzed statistically.Result: The questionnaires were filled for 133 patients with acneand 133 healthy controls. Twenty-nine patients with acne (21.8%)and 12 patients in the control group (9.1%) were smokers, and thedifference between them was significant (P = 0.004). The numberof cigarettes smoked per day was significantly different in thetwo groups (4.75 in the case group versus 1.88 in the controlgroup). No correlation was found between smoking and acnelocalization, severity of acne, the type of lesion, symptomaticor asymptomatic nature of acne and acne complications. In thecase group, the smokers developed acne at an older age thanthe non-smokers.Conclusion: Patients with acne were more likely to smoke thanpatients without acne; thus, smoking might be a factor affectingthe incidence of acne.
Meibodi Naser Tayyebi; Nahidi Yalda; Javidi Zari; Taheri Ahmad Reza; Jahanfakhr Monavar Afzalaghaee Samaneh
Volume 15, Issue 3 , 2012, , Pages 89-94
Abstract
Background: Precancerous lesions are disorders that are highlylikely to become malignant. Early diagnosis of precancerous skinlesions helps to prevent skin cancers. The aim of this study wasclinicopathological assessment of precancerous skin lesions inpatients referred to the dermatology department of ...
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Background: Precancerous lesions are disorders that are highlylikely to become malignant. Early diagnosis of precancerous skinlesions helps to prevent skin cancers. The aim of this study wasclinicopathological assessment of precancerous skin lesions inpatients referred to the dermatology department of Imam Rezahospital.Method: Two hundred and nine patients who were diagnosed withprecancerous lesions and referred to the dermatology departmentof Imam Reza hospital from 1997 to 2007 were studied. Studyparameters included participants’ age, sex and occupation, typeof precancerous skin lesion, clinicopathological type of the lesionand location. The data was collected from the patients’ recordsin the dermatology department and their microscopic slides inthe pathology department.Result: The most common precancerous skin lesion was actinickeratosis (68.4%) followed by Bowen’s disease (7.2%). About67.5% of the patients were male with a mean age of 61.7 years.Moreover, 53.1% of the patients worked outdoors. The mostcommon site of the lesions was head and neck (83.3%) and 18.7%of lesions were associated with malignancy. The most commonpathological form of actinic keratosis was the proliferative type(28.9%).Conclusion: The results of this study showed that precancerousskin lesions were more prevalent in men aged over 50 years, insun-exposed areas and in occupations practiced outdoors. Inaddition to squamous cell carcinoma, these lesions could alsobe associated with basal cell carcinoma.
Javidi Zari; Maleki Masood; Mashayekhi Vahid; Meibodi Naser Tayyebi; Nahidi Yalda
Volume 11, Issue 1 , 2008, , Pages 25-29
Abstract
Introduction: Genital infections with human papilloma virus (HPV) are the most common sexually transmitted disease in the United States. Several predisposing factors are known for this infection. So far, no studies on the risk factors and clinico-epidemiologic aspects of genital warts in Iran have been ...
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Introduction: Genital infections with human papilloma virus (HPV) are the most common sexually transmitted disease in the United States. Several predisposing factors are known for this infection. So far, no studies on the risk factors and clinico-epidemiologic aspects of genital warts in Iran have been reported. So, we performed this study to evaluate epidemiologic aspects of anogenital warts in Mashhad, Iran. Methods: In this case-control study, 100 patients with genital warts who referred to the dermatology clinic of Imam-Reza hospital (August 2005 - August 2007) and 100 age, sex and marital status matched healthy controls were included. Clinical and epidemiologic data were recorded using designed questionnaire. Finally, chi-square and t-student tests were used for statistical analysis. Results: Male to female ratio was 0.87. The majority of the patients aged 30-39 years. Glans of the penis and posterior fourchette were the most common sites of involvement. Positive history of sexual contacts and sexual transmitted diseases (STDs), use of condom, pregnancy, addiction, use of swimming pools and number of marriages were significantly different in two groups. Conclusion: Younger age, higher number of marriages, having several partners, non-traditional sexual behavior, pregnancy, use of swimming pools, refuse to use condoms, history of other STDs, immune suppression, use of immunosuppressive drugs and topical steroids were the main risk factors of anogenital warts in this study.
Javidi Zari; Tayyebi-Maybodie Naser; Taheri Ahmad Reza; Nahidi Yalda
Volume 10, Issue 4 , 2007, , Pages 309-315
Abstract
Background and aim: Psoriasis is a dermatologic disease which not only involves the patient physically, but also affects patient's quality of life. Due to its life time duration and psychologic burden, we decided to evaluate patient's quality of life using psoriasis disability index (PDI). Materials ...
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Background and aim: Psoriasis is a dermatologic disease which not only involves the patient physically, but also affects patient's quality of life. Due to its life time duration and psychologic burden, we decided to evaluate patient's quality of life using psoriasis disability index (PDI). Materials and methods: From August 2006 till March 2007, 80 patients referring to Imam-Reza dermatology clinic completed the PDI questionnaire and a demographic questionnaire. Collected data were analyzed by t-test, one way ANOVA tests using SPSS software. Results: 46.2% of patients were male and 53.8% female. The mean age of patients was 40.2 years. 10% had positive family history of psoriasis. 47.5% had a history of hospitalization. 41.3% had articular and 53.8% had nail involvement. Mean morbidity duration was 12.6 years and mean PDI score was 17.4±10 (maximum and minimum scores: 37 and 1 respectively). There was significant difference in mean PDI score in groups considering age, sex, education, location, duration and extent of disease, hospitalization history, nail involvement and type of treatment. Most disability was seen in the treatment field (both sexes) and occupation /school (men) and least disability was seen in individual relationships.Discussion: Psoriasis can reduce the patient's quality of life and satisfaction severely. Therefore supportive strategies can improve their quality of life.
Meybodi Naser Tayebi; Javidi Zari; Memar Bahram; Farhadi Farzaneh; Nahidi Yalda
Volume 10, Issue 3 , 2007, , Pages 203-210
Abstract
Background and aim: Basal cell carcinoma (BCC) is the most common skin cancer in white-skin populations. Recent studies suggest that BCC is not a single entity and different histological subtypes show different clinical behavior and might have different etiology. The aim of this study was to assess differences ...
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Background and aim: Basal cell carcinoma (BCC) is the most common skin cancer in white-skin populations. Recent studies suggest that BCC is not a single entity and different histological subtypes show different clinical behavior and might have different etiology. The aim of this study was to assess differences in age, sex, site of distribution and proliferative activity in histological subtypes of BCC. In addition association of BCC with solar keratoses is assessed.Materials and methods: We studied 299 cases of BCC from the archives of department of pathology, Mashad University of Medical Sciences in a three-year period. Clinical data were recorded and histological slides were rewiewed to confirm the diagnosis and histological subtypes. Results: We recorded 345 BCC in 299 patients with mean age of 59.2 years. 70.8% of patients were male and 29.2% were female. Ninety-four percent of lesions were located in head and neck. Solid pattern of BCC was the most frequent subtype. In superficial and micronodular subtypes, patients were younger and the oldest patients had basosquamous BCC. Adenoid BCC had the most mitotic activity. In 22.2% of cases association with solar keratoses were observed.Conclusion: This study showed difference in age, sex, site of tumor, and proliferative activity in various histological subtypes of BCC that might represent different etiologic factors in different subtypes.
Pezeshkpour Fakhro-Zaman; Layegh Pouran; Nahidi Yalda; Layegh Parvaneh
Volume 10, Issue 3 , 2007, , Pages 245-251
Abstract
Psoriasis is a chronic inflammatory proliferative disorder of the skin that appears in many different forms and affect different parts of the body including the nails and joints. It may affect the quality of life by causing psychosocial stress. Psoriatic arthritis is a seronegative spondyloarthropathy ...
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Psoriasis is a chronic inflammatory proliferative disorder of the skin that appears in many different forms and affect different parts of the body including the nails and joints. It may affect the quality of life by causing psychosocial stress. Psoriatic arthritis is a seronegative spondyloarthropathy with involvement of axial and peripheral joints. Involvement of temporomo andibular joint is also a rare presentation of psoriatic arthritis . In this article we report a rare case of bilateral temporomandibular joint ankylosis secondary to psoriasis in a 50-year-old woman .