Banihashemi Mahnaz; Nahidi Yalda; Meibodi Naser Tayyebi; Jarrahi Lida; Livani Fatemeh; Seifnia Sahar
Abstract
Background: Pemphigus vulgaris (PV) is a rare autoimmune blistering disease of the skin and mucous membranes. Because vitamin D deficiency is associated with many immune disorders, we compared the levels of vitamin D between PV patients and healthy controls. Methods: Vitamin D level of 20 patients with ...
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Background: Pemphigus vulgaris (PV) is a rare autoimmune blistering disease of the skin and mucous membranes. Because vitamin D deficiency is associated with many immune disorders, we compared the levels of vitamin D between PV patients and healthy controls. Methods: Vitamin D level of 20 patients with PV was compared with 20 healthy individuals matched for age, gender, hours spent in the sun, body mass index (BMI) and daily vitamin D intake at the same time interval. The severity of the disease was estimated according to ABSIS score. The serum level of 25-hydroxyvitamin D (25OHD) was measured by a commercial ELISA test. Results: Vitamin D deficiency in the pemphigus vulgaris group (75%) was higher than healthy controls (45%) (P = 0.053). Mean level of vitamin D in PV patients was significantly lower than healthy controls, and was in the range of vitamin deficiency (P ? 0.05). No significant relationship was observed between the severity of the PV disease and vitamin D levels (P > 0.05). Conclusions: Based on the results of the present study, the mean level of vitamin D in patients with PV was significantly lower than healthy people. Based on our findings and given the important role of vitamin D in preventing inflammatory and autoimmune diseases, vitamin D deficiency can be considered as a factor triggering the onset of PV.
Nahidi Yalda; Meibodi Naser Tayyebi; Ghazvini Kiarash; Esmaeeli Habiballah; Nahidi Mahsa
Volume 18, Issue 4 , 2015, , Pages 163-168
Abstract
Background: Mycosis fungoides is the most common type of primary cutaneous T-cell lymphoma. Its etiopathogenesis, despite numerous studies, remains unclear. Environmental, viral, and genetic factors have been proposed as its potential etiologic factors. In recent years, viral agents of herpes virus family ...
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Background: Mycosis fungoides is the most common type of primary cutaneous T-cell lymphoma. Its etiopathogenesis, despite numerous studies, remains unclear. Environmental, viral, and genetic factors have been proposed as its potential etiologic factors. In recent years, viral agents of herpes virus family such as human herpes virus 8 (HHV-8) have been noticed.Objective: The aim of this study was to evaluate the association between the presence of HHV-8 and mycosis fungoides.Methods: This case-control study was done on skin biopsies of 42 mycosis fungoides cases referred to the Department of Pathology, Imam Reza Hospital, Mashhad, Iran from 2004 to2012, and 42 age and sex matched samples of melanocytic nevi. PCR was performed to detect HHV-8 in biopsy samples of the patients and the control group. Statistical analysis was done using the IBM SPSS Statistics (IBM Corp., Armonk, NY, USA) 20.Results: Of 42 patients with MF, 25 were male and 17 were female with a male to female ratio of 1.4. The mean age of the patients was 51.2 years. Most of the patients were in the age group over 60 years. Clinical lesions of the majority of the patients were papules and plaques. HHV-8 DNA was not found in any of the mycosis fungoides samples using the PCR method.Conclusion: Based on our study results, HHV-8 does not play an important role in the pathogenesis of mycosis fungoides.
Layegh Pouran; Meibodi Naser Tayyebi; Nahidi Yalda; Sepehri Zahra; Nazari Ali; Shakeri Mohammad Taghi
Volume 17, Issue 1 , 2014, , Pages 8-12
Abstract
Background: The description on patients with pigmented back patches is rarely reported in the literature. We decided to study the clinicopathological aspects of these patients for reaching a better understanding of this disease.Method: In this study, the clinicopathological aspects and probable responsible ...
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Background: The description on patients with pigmented back patches is rarely reported in the literature. We decided to study the clinicopathological aspects of these patients for reaching a better understanding of this disease.Method: In this study, the clinicopathological aspects and probable responsible factors in the manifestation of posterior pruritic pigmented patches in patients referred to the dermatology clinic of Qaem University Hospital from October 2007 to September 2009 were surveyed.Result: All 60 patients who were enrolled in our study were female with a mean age of 31.43±9.71 years. Six patients did not consent to biopsy. The most c
Nahidi Yalda; Meibodi Naser Tayyebi; Layegh Pouran; Esmaeeli Habiballah; Hosseini Fatemeh Sadat
Volume 16, Issue 2 , 2013, , Pages 57-63
Abstract
Background: Melasma is a common acquired hyperpigmentationdisorder often appearing on the face of young women. Melasmais classified into four groups based on Wood’s lamp examination:epidermal, dermal, mixed, and indeterminate. The goal of this studywas to evaluate the relationship between clinicoepidemiologicalcharacteristics ...
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Background: Melasma is a common acquired hyperpigmentationdisorder often appearing on the face of young women. Melasmais classified into four groups based on Wood’s lamp examination:epidermal, dermal, mixed, and indeterminate. The goal of this studywas to evaluate the relationship between clinicoepidemiologicalcharacteristics of melasma and the level of involvement underWood’s lamp examination.Method: In a cross sectional study, 50 melasma patients whowere visited at the dermatology clinic of Imam Reza Hospitalfrom March 2010 to September 2011 were studied. The levelof melasma involvement in all patients was determined usinga Wood’s lamp, and the patients’ information such as age,occupation, location of melasma, marital status, pregnancy, oralcontraceptive pill consumption and Fitzpatrick skin type wascollected in a questionnaire.Result: In single patients, dermal involvement and in marriedpatients, epidermal involvement was more common. Involvementwas more frequently dermal in jobs with exposure to sun andmore epidermal in indoor jobs. In the malar region, epidermalinvolvement was more common. In patients with a history ofpregnancy, epidermal involvement was more prevalent as well,while in the participants without a history of pregnancy, dermalinvolvement was more frequent. In the pregnant patients withmelasma, epidermal involvement was more frequent. In patientswithout a family history of melasma, epidermal involvement wasmore frequently observed than the other two levels of involvement.Conclusion: Based on the findings of this study, melasma in caseswith the involvement of the malar region, starting in pregnancy,in patients without a family history of melasma, and in theindividuals who have indoor occupations is most likely to beepidermal and may have a better response to treatment. On theother hand, melasma in single persons and in those who haveoutdoor occupations and are exposed to sun light is mostly dermalwith a worse response to treatment according to previous studies.
Banihashemi Mahnaz; Fazel Zahra; Meibodi Naser Tayyebi; Imani Mohammad; Zabolinejad Naghmeh
Volume 16, Issue 1 , 2013, , Pages 42-44
Abstract
A 38- year-old man in good general health and normal intellectualfunctioning referred to the dermatologic clinic with numerouspruritic reticulate pigmentations on his neck, chest and upperback since 10 years ago. We noticed similar lesions on his axillae,groin and infra mammary area with no family background.
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A 38- year-old man in good general health and normal intellectualfunctioning referred to the dermatologic clinic with numerouspruritic reticulate pigmentations on his neck, chest and upperback since 10 years ago. We noticed similar lesions on his axillae,groin and infra mammary area with no family background.
Meibodi Naser Tayyebi; Nahidi Yalda; Javidi Zari; Taheri Ahmad Reza; Jahanfakhr Monavar Afzalaghaee Samaneh
Volume 15, Issue 3 , 2012, , Pages 89-94
Abstract
Background: Precancerous lesions are disorders that are highlylikely to become malignant. Early diagnosis of precancerous skinlesions helps to prevent skin cancers. The aim of this study wasclinicopathological assessment of precancerous skin lesions inpatients referred to the dermatology department of ...
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Background: Precancerous lesions are disorders that are highlylikely to become malignant. Early diagnosis of precancerous skinlesions helps to prevent skin cancers. The aim of this study wasclinicopathological assessment of precancerous skin lesions inpatients referred to the dermatology department of Imam Rezahospital.Method: Two hundred and nine patients who were diagnosed withprecancerous lesions and referred to the dermatology departmentof Imam Reza hospital from 1997 to 2007 were studied. Studyparameters included participants’ age, sex and occupation, typeof precancerous skin lesion, clinicopathological type of the lesionand location. The data was collected from the patients’ recordsin the dermatology department and their microscopic slides inthe pathology department.Result: The most common precancerous skin lesion was actinickeratosis (68.4%) followed by Bowen’s disease (7.2%). About67.5% of the patients were male with a mean age of 61.7 years.Moreover, 53.1% of the patients worked outdoors. The mostcommon site of the lesions was head and neck (83.3%) and 18.7%of lesions were associated with malignancy. The most commonpathological form of actinic keratosis was the proliferative type(28.9%).Conclusion: The results of this study showed that precancerousskin lesions were more prevalent in men aged over 50 years, insun-exposed areas and in occupations practiced outdoors. Inaddition to squamous cell carcinoma, these lesions could alsobe associated with basal cell carcinoma.
Javidi Zari; Maleki Masood; Mashayekhi Vahid; Meibodi Naser Tayyebi; Nahidi Yalda
Volume 11, Issue 1 , 2008, , Pages 25-29
Abstract
Introduction: Genital infections with human papilloma virus (HPV) are the most common sexually transmitted disease in the United States. Several predisposing factors are known for this infection. So far, no studies on the risk factors and clinico-epidemiologic aspects of genital warts in Iran have been ...
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Introduction: Genital infections with human papilloma virus (HPV) are the most common sexually transmitted disease in the United States. Several predisposing factors are known for this infection. So far, no studies on the risk factors and clinico-epidemiologic aspects of genital warts in Iran have been reported. So, we performed this study to evaluate epidemiologic aspects of anogenital warts in Mashhad, Iran. Methods: In this case-control study, 100 patients with genital warts who referred to the dermatology clinic of Imam-Reza hospital (August 2005 - August 2007) and 100 age, sex and marital status matched healthy controls were included. Clinical and epidemiologic data were recorded using designed questionnaire. Finally, chi-square and t-student tests were used for statistical analysis. Results: Male to female ratio was 0.87. The majority of the patients aged 30-39 years. Glans of the penis and posterior fourchette were the most common sites of involvement. Positive history of sexual contacts and sexual transmitted diseases (STDs), use of condom, pregnancy, addiction, use of swimming pools and number of marriages were significantly different in two groups. Conclusion: Younger age, higher number of marriages, having several partners, non-traditional sexual behavior, pregnancy, use of swimming pools, refuse to use condoms, history of other STDs, immune suppression, use of immunosuppressive drugs and topical steroids were the main risk factors of anogenital warts in this study.
