Reza Yaghoobi; Nader Pazyar; Hooman Kalantar; Azita Nikoo; Zahra Naraghi; Kambiz Kamyab; Alireza Ganadan; Zohre Khodashenas; Azadeh Goodarzi; Fatemeh Mohaghegh
Volume 20, Issue 1 , 2017, , Pages 21-25
Abstract
Background: Basal cell carcinomas (BCC) are the most prevalent among non-melanoma skin cancers (NMSC), which correspond to the most common skin cancers. BCC histopathological subtyping is a problem in therapeutic management. Therefore, we have decided to perform a histopathologic study for better classification ...
Read More
Background: Basal cell carcinomas (BCC) are the most prevalent among non-melanoma skin cancers (NMSC), which correspond to the most common skin cancers. BCC histopathological subtyping is a problem in therapeutic management. Therefore, we have decided to perform a histopathologic study for better classification of BCCs based on interobserver diagnostic judgment. Methods: We conducted this cross-sectional study on 100 randomly selected pathologically confirmed BCC cases of various subtypes at Razi Hospital, Tehran, Iran during 2013 and 2014. A total of four dermatopathologists independently reviewed each pathology slide to evaluate the interobserver concordance rate. Results: The overall Fleiss’ kappa statistic (kappa) for the BCC subtypes was 0.18 (P<0.001), which indicated slight agreement. We observed moderate agreement on superficial and nodular BCC (kappa: 0.0-0.4); fair agreement on infiltrative and keratotic BCC (kappa: 0.2-0.4); and slight agreement on pigmented, micronodular, and metatypical BCC (kappa: 0.0-0.2). There was moderate agreement diagnosis for the low and high risk growth pattern categories. Conclusion: Overall, we found that the dermatopathologists had inconsistent nomenclature for the BCC subtypes, however they had better agreement for the diagnosis of superficial, nodular, and infiltrative subtypes and the high risk growth pattern.
Mona Abdolreza; Vahide Lajevardi; Kamran Balighi; Kambiz Kamyab; Zahra Naraghi; Soroush Daklan
Volume 15, Issue 1 , 2012, , Pages 26-28
Abstract
A 25-year-old woman referred to our department with a lesion in the anterior part of her neck (Figure 1) since childhood. She complained of a clear discharge from the lesion which increased with pressure. Two years ago, the lesion was treated with electrosurgery but relapsed a few months later. Examination ...
Read More
A 25-year-old woman referred to our department with a lesion in the anterior part of her neck (Figure 1) since childhood. She complained of a clear discharge from the lesion which increased with pressure. Two years ago, the lesion was treated with electrosurgery but relapsed a few months later. Examination revealed an erythematous papule in the anteriorinferior part of the neck with a clear mucoid discharge from its orifice upon pressure. Physical exam was otherwise normal. The patient had no other medical problems. She had never taken any medications. There was no family history of a similar problem. We advised the patient to be visited for excisional biopsy of the lesion.
Mostafa Mirshams Shahshahani; Mahmood Razzaghi; Amir Houshang Ehsani; Pedram Normohamadpour; Zahra Naraghi; Kambiz Kamyab; Sara Sabouri Rad
Volume 14, Issue 1 , 2011, , Pages 1-5
Abstract
Background: Surgery is the most frequent treatment modality for basal cell carcinoma but in spite of its high cure rate, the frequency of incomplete excision varies widely (0.7-50%) among dermatologic centers. Our case series was designed to determine the frequency of incompletely excised basal cell ...
Read More
Background: Surgery is the most frequent treatment modality for basal cell carcinoma but in spite of its high cure rate, the frequency of incomplete excision varies widely (0.7-50%) among dermatologic centers. Our case series was designed to determine the frequency of incompletely excised basal cell carcinoma and the related risk factors. Methods: A total of 1424 basal cell carcinoma (1040 patients) lesions which were excised in Razi Dermatology Hospital of Tehran from 2006 to 2008 were evaluated in this case series and their findings were analyzed with SPSS software. Results: Incidence of incomplete excision was 12% and involvement of the deep margin was observed in 54% of these lesions. Factors related to incomplete excision were infiltrative, morpheic and micronodular subtypes, lesions larger than 20 mm, those repaired by skin grafts and those that received local anesthesia. There was no statistically significant difference in age, sex, site of lesions and childhood history of radiotherapy for tinea capitis. Conclusion: Recognizing the risk factors related to incomplete excision of BCCs would help us consider a wider excision margin for high risk tumors.