Jeelani Shazia; Lanker Audil; Jeelani Nasir; Masood Qazi; Fazili Tawheeda; Majid Huma
Volume 19, Issue 3 , 2016, , Pages 79-85
Abstract
Background: Onychomycosis (OM) is the infection of nails caused by a variety of fungi. As systemic antifungal treatment is necessary in the majority of patients, appropriate diagnostic techniques are important to ensure a correct diagnosis and treatment. Objective: This study was carried out to evaluate ...
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Background: Onychomycosis (OM) is the infection of nails caused by a variety of fungi. As systemic antifungal treatment is necessary in the majority of patients, appropriate diagnostic techniques are important to ensure a correct diagnosis and treatment. Objective: This study was carried out to evaluate the clinical, mycological, and histological aspects of onychomycosis in detail. Methods: A cross-sectional study was carried out on 216 patients with a high degree of clinical suspicion for OM. Clinical details including the site, morphological type, and associated diseases were noted in each case. The specimens obtained were subjected to three diagnostic tests: direct microscopy, fungal culture, and histopathological examination using PAS staining. Results: OM was more common in young adults in the age group 20-40 years (40.2%). In the majority (46.3%) of the cases, the duration of the disease was ≤ 1year. Distal and lateral subungual onychomycosis was the most common (73.6%) clinical type. A high incidence of toe nail onychomycosis (68.5%) was noted in our study. Dermatophytes were the most common etiological agent. Among the dermatophytes, Trichophyton mentagrophytes was the most common isolated fungus. Histopathological examination using PAS staining (HPE-PAS) showed the highest sensitivity of 91.6% among the three tests. Conclusion: Dermatophytes are the main agents responsible for OM in this region with T. mentagrophytes being the most common isolate. This study also demonstrated the importance of performing routine histopathology in addition to direct examination and culture for the diagnosis of onychomycosis.
Nuzhatun Nisa; Masood Qazi; Iffat Shah
Volume 14, Issue 1 , 2011, , Pages 29-31
Abstract
In any description of leg ulcers in systemic lupus erythematosus (SLE), pyoderma gangrenosum (PG) earns a mention at least for its being quite rare in such patients. The causative role of aPL (antiphospholipid antibody) in dermatological manifestations of SLE is undermined by the occurrence of PG in ...
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In any description of leg ulcers in systemic lupus erythematosus (SLE), pyoderma gangrenosum (PG) earns a mention at least for its being quite rare in such patients. The causative role of aPL (antiphospholipid antibody) in dermatological manifestations of SLE is undermined by the occurrence of PG in aPL negative SLE patients. To the best of our knowledge, there are only two reports of PG in aPL negative SLE patients; in one, PG preceded the diagnosis of SLE by several years while the other was associated with the reactivation of the disease in an already diagnosed SLE patient. In view of the rarity of this association, we hereby present another similar case to substantiate the documentation of the association of the entities.