Nahidi Yalda; Meibodi Naser Tayyebi; Ghazvini Kiarash; Esmaeeli Habiballah; Nahidi Mahsa
Volume 18, Issue 4 , 2015, , Pages 163-168
Abstract
Background: Mycosis fungoides is the most common type of primary cutaneous T-cell lymphoma. Its etiopathogenesis, despite numerous studies, remains unclear. Environmental, viral, and genetic factors have been proposed as its potential etiologic factors. In recent years, viral agents of herpes virus family ...
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Background: Mycosis fungoides is the most common type of primary cutaneous T-cell lymphoma. Its etiopathogenesis, despite numerous studies, remains unclear. Environmental, viral, and genetic factors have been proposed as its potential etiologic factors. In recent years, viral agents of herpes virus family such as human herpes virus 8 (HHV-8) have been noticed.Objective: The aim of this study was to evaluate the association between the presence of HHV-8 and mycosis fungoides.Methods: This case-control study was done on skin biopsies of 42 mycosis fungoides cases referred to the Department of Pathology, Imam Reza Hospital, Mashhad, Iran from 2004 to2012, and 42 age and sex matched samples of melanocytic nevi. PCR was performed to detect HHV-8 in biopsy samples of the patients and the control group. Statistical analysis was done using the IBM SPSS Statistics (IBM Corp., Armonk, NY, USA) 20.Results: Of 42 patients with MF, 25 were male and 17 were female with a male to female ratio of 1.4. The mean age of the patients was 51.2 years. Most of the patients were in the age group over 60 years. Clinical lesions of the majority of the patients were papules and plaques. HHV-8 DNA was not found in any of the mycosis fungoides samples using the PCR method.Conclusion: Based on our study results, HHV-8 does not play an important role in the pathogenesis of mycosis fungoides.
Nahidi Yalda; Meibodi Naser Tayyebi; Layegh Pouran; Esmaeeli Habiballah; Hosseini Fatemeh Sadat
Volume 16, Issue 2 , 2013, , Pages 57-63
Abstract
Background: Melasma is a common acquired hyperpigmentationdisorder often appearing on the face of young women. Melasmais classified into four groups based on Wood’s lamp examination:epidermal, dermal, mixed, and indeterminate. The goal of this studywas to evaluate the relationship between clinicoepidemiologicalcharacteristics ...
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Background: Melasma is a common acquired hyperpigmentationdisorder often appearing on the face of young women. Melasmais classified into four groups based on Wood’s lamp examination:epidermal, dermal, mixed, and indeterminate. The goal of this studywas to evaluate the relationship between clinicoepidemiologicalcharacteristics of melasma and the level of involvement underWood’s lamp examination.Method: In a cross sectional study, 50 melasma patients whowere visited at the dermatology clinic of Imam Reza Hospitalfrom March 2010 to September 2011 were studied. The levelof melasma involvement in all patients was determined usinga Wood’s lamp, and the patients’ information such as age,occupation, location of melasma, marital status, pregnancy, oralcontraceptive pill consumption and Fitzpatrick skin type wascollected in a questionnaire.Result: In single patients, dermal involvement and in marriedpatients, epidermal involvement was more common. Involvementwas more frequently dermal in jobs with exposure to sun andmore epidermal in indoor jobs. In the malar region, epidermalinvolvement was more common. In patients with a history ofpregnancy, epidermal involvement was more prevalent as well,while in the participants without a history of pregnancy, dermalinvolvement was more frequent. In the pregnant patients withmelasma, epidermal involvement was more frequent. In patientswithout a family history of melasma, epidermal involvement wasmore frequently observed than the other two levels of involvement.Conclusion: Based on the findings of this study, melasma in caseswith the involvement of the malar region, starting in pregnancy,in patients without a family history of melasma, and in theindividuals who have indoor occupations is most likely to beepidermal and may have a better response to treatment. On theother hand, melasma in single persons and in those who haveoutdoor occupations and are exposed to sun light is mostly dermalwith a worse response to treatment according to previous studies.