V Sadeghi; N Maghsoudi; Y Dowlati; AA Deldar; M Heydari Seraj
Volume 8, Issue 5 , 2005, , Pages 388-393
SM Davoudi; AA Karimi Zarchi; S Ghafouri Manesh; AR Firooz; M Nasiri Kashani; Y Dowlati
Volume 8, Issue 3 , 2005, , Pages 166-170
Abstract
Background: Eczema is one of the most widely spread inflammatory skin disorders contact dermatitis is an eczematous dermatitis that is produced as a result of contact with a substance in the environment. The substance can act as an irritant or allergen. Every country has allergen particular to itself. ...
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Background: Eczema is one of the most widely spread inflammatory skin disorders contact dermatitis is an eczematous dermatitis that is produced as a result of contact with a substance in the environment. The substance can act as an irritant or allergen. Every country has allergen particular to itself. Objective: Determining the frequency of skin allergens in patients with contact dermatitis in Tehran. Patients and Methods: In this cross-sectional descriptive study, all the data about the patients with chronic contact dermatitis who were visited in a dermatology clinic in Tehran from the year 1993 to 2003 and patch tested with 23 allergens of European standard series (ESS) were analyzed. Results: In this study 222 patients were surveyed. The mean age of the patients was 33.5 years (SD=13.8). 66.5% of the patients were female. The most common site of involvement (49%) was their hands. The mean duration of the disease was 54 months (SD=62). Clinical diagnosis included: 59% allergic contact dermatitis, 24% irritant dermatitis, 10% atopic dermatitis, and 7% other types of dermatitis. 145 (65.3%) of them had at least one positive reaction. The most common allergens were: Nickle sulfate 22.6%, cobalt chloride 14.5%, and fragrance mix 13.6%. Conclusion: Nickel was the most common contact allergen among the patients surveyed.
AR Firooz; AR Khatami; A Khamesipour; M Nassiri Kashani; MA Nilforoushzadeh; F Behnia; HR Pazoki Toroudi; Y Dowlati
Volume 7, Issue 4 , 2004, , Pages 209-218
Abstract
Background: Several treatment modalities have been used for cutaneous leishmaniasis (CL) with various results. In vitro and in vivo studies have shown inhibitory effects of zinc sulfate (ZnSO4) on Leishmania parasites. Objective: To compare the efficacy of intralesional injections of 2% ZnSO4 solution ...
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Background: Several treatment modalities have been used for cutaneous leishmaniasis (CL) with various results. In vitro and in vivo studies have shown inhibitory effects of zinc sulfate (ZnSO4) on Leishmania parasites. Objective: To compare the efficacy of intralesional injections of 2% ZnSO4 solution with meglumine antimonate (Glucantime) in the treatment of acute Old World CL. Patients and Methods: Seventy-two patients with CL with a duration of less than 8 weeks were recruited in a randomized, double-blind, clinical trial in Isfahan province – an area endemic for Leishmania major – after giving written informed consent. They were treated with 6 weekly intralesional injections of either 2% sterile ZnSO4 solution or Glucantime prepared in identical vials. The primary outcome measure was complete re-epithelialization of CL lesions. Results: Among 36 patients with 53 lesions treated with ZnSO4 and 36 patients with 53 lesions treated with Glucantime, 13 patients with 19 lesions and 22 patients with 31 lesions completed the trial, respectively. Inadequacy of treatment was the main reason for drop-out in 12 (33.3%) and 2 (5.5%) patients in ZnSO4 and Glucantime groups, respectively (P<0.05). Complete re-epithelialization was observed in 2 (10.5%) and 19 (61.3%) lesions 1 week after the end of treatment in the ZnSO4 and Glucantime groups, respectively (P<0.05). Conclusion: A six-week course of weekly intralesional injections of 2% ZnSO4 solution was less effective than Glucantime in the treatment of acute Old World CL.
AR Firooz; M Rashighi Firoozabadi; B Ghazi Saidi; Y Dowlati
Volume 4, Issue 3 , 2001, , Pages 11-17
Abstract
Background: Alopecia areata (AA) is a common disease with an unknown etiology. It is a chronic disease with causes severe disfigurement. So it may significantly affect the patients’ quality of life (QOL). This study was designed to evaluate illness perception and QOL in patients with AA. Patients ...
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Background: Alopecia areata (AA) is a common disease with an unknown etiology. It is a chronic disease with causes severe disfigurement. So it may significantly affect the patients’ quality of life (QOL). This study was designed to evaluate illness perception and QOL in patients with AA. Patients and Methods: A questionnaire consisting of 28 questions about causes, course and the impact on QOL were given to patients with AA older than 12 years attending a private skin clinic in 1999 in Tehran. The questions were asked as closed questions and the patients answered them anonymously as “I agree”, “I do not know” and “I disagree”. Only questionnaires with more than 80% of questions answered were analyzed. The role of age, sex, duration, previous treatment, education, severity and family history of AA were assessed. Results: 80 patients (42 male and 38 female) with a mean age of 27.5±9.3 years and disease duration of 7.8±7.7 years entered the study. 60 of them had AA and 20 had alopecia totalis/universalis (AT/AU). 77% of patients believed on the role of stress as the cause of disease, more in older patients and shorter duration. 17% believed on the role of genetic background, more in patients with positive family history of AA or longer duration of disease. AA had a pronounced effect on QOL of 58% of patients, more in younger patients. 51% of patients considered their disease as severe, more in younger patients or severe disease. Only 58% of patients considered their treatments effective and 49% of them believed it will improve with praying. Conclusion: AA may considerably affect various aspects of patients’ lives. The knowledge of patients about the causes and course of this disease is very limited. Physicians should spend more time on the education of patients.
N Bouzari; AR Firooz; H Tabatabai; Y Dowlati
Volume 4, Issue 3 , 2001, , Pages 24-29
Abstract
Background: Minoxidil is currently an approved treatment for androgenetic alopecia. Topical tretinoin can enhance skin absorption of minoxidil. Objective: This study has been done in order to determine the efficacy and safety of the solution of 0.5% minoxidil+0.05% tretinoin compared to 2% minoxidil ...
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Background: Minoxidil is currently an approved treatment for androgenetic alopecia. Topical tretinoin can enhance skin absorption of minoxidil. Objective: This study has been done in order to determine the efficacy and safety of the solution of 0.5% minoxidil+0.05% tretinoin compared to 2% minoxidil in androgenetic alopecia in men. Patients and Methods: In a randomized, double-blind, parallel-group, controlled study, 117 male patients with androgenetic alopecia, 18-40 years old, Hamilton grades of 2-5 and duration of alopecia less than 10 years were evaluated. These patients were divided in two groups randomly, one group received a solution containing 0.5% minoxidil and 0.05% tretinoin and another group received 2% minoxidil for at least 4 months. The patients used 1ml of the solution twice daily. 2 and 4 months after treatment, the patients were evaluated for efficacy (Patients, idea about improvement of hair loss, hair regrowth and wash test) and safety (Erythema, scaling and pruritus). The quantitative data were analyzed by ANOVA and the qualitative data were analyzed by qui-squared test. Results: There were no significant differences between two groups regarding the age, duration and grade of hair loss. After 4 months of treatment, the percentage of patients reporting improvement in hair loss and hair regrowth were 81.6% and 56% in minoxidil 2% group and 65.4% and 59.6% in minoxidil+tretinoin group, respectively (P>0.05 for all). At the same time, the numbers of hairs in wash test were 156 in minoxidil 2% group and 149 in minoxidil+tretinoin group (P>0.05). Conclusion: There was no significant difference in efficacy and safety of 4 months treatment with the solution of 0.5% minoxidil and 0.05% tretinoin compared to the solution of 2% minoxidil in the treatment of androgenetic alopecia in men.
AR Gholami; A Khamesipour; A Momeni; T Ghazanfari; MA Nilforoush Zadeh; Z Darajeh; Y Dowlati
Volume 3, Issue 3 , 2000, , Pages 2-6
Abstract
Background: Cutaneous leishmaniasis (CL) is a protozoan disease of the skin caused by a wide range of italic species. The disease is endemic in many countries. It has been recognized as a major public health problem in Iran. Many treatments have been suggested for it but none of them was fully effective. ...
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Background: Cutaneous leishmaniasis (CL) is a protozoan disease of the skin caused by a wide range of italic species. The disease is endemic in many countries. It has been recognized as a major public health problem in Iran. Many treatments have been suggested for it but none of them was fully effective. Objective: The objective of this study was to compare the efficacy of a 5% garlic cream with placebo in CL. Patients and Methods: A double blind, placebo controlled study was performed in Isfahan and Jahrom in 1997 and 1998. 197 patients were randomly selected. Exclusion criteria were: pregnancy, lactation, age less than 5 years and duration of disease more than 100 days. Each patient received garlic cream 5% or placebo for 3 weeks and was followed for another period of 40 days. Results: The study was completed as planned in 171 patients. 96 were treated with garlic 5% cream and 75 with placebo. Complete healing occurred in 18 (18.75%) of garlic group in comparison with 15 (20%) of placebo group. The difference was not significant (P=0.9865). Conclusion: 5% garlic cream was not effective in treatment of cutaneous leishmaniasis. Further studies with higher concentrations or different vehicle are needed.
E Firooz Ebne Ahmadi; P Sooudi; Y Dowlati
Volume 2, Issue 3 , 1999, , Pages 15-20
Abstract
Introduction: Since there is no study in our country about determination the effects of psychogenic factors on psoriasis and because it seems necessary to evaluate the triggering factors of disease in order to lengthen the remission period and decrease the costs and complications, this study was performed ...
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Introduction: Since there is no study in our country about determination the effects of psychogenic factors on psoriasis and because it seems necessary to evaluate the triggering factors of disease in order to lengthen the remission period and decrease the costs and complications, this study was performed to identify the relationship of stress with psoriasis expression and the severity of skin lesions. Materials and Methods: This is a prospective case-control study with simple random sampling which has been performed on 95 subjects above 18 year old in Razi Hospital. The case group was selected from psoriatic patients and the control group from non-psoriatic patients in whom stress does not have any effect on their disease. Two groups were matched for age and sex. Stress was assessed by Holmes and Rahe protocol with some modifications approved by a psychiatrist. Severity of skin lesions in psoriatic patients was also assessed by PASI score. Data Analysis was performed by T test, multiple logistic regression and correlation of Spearman using SPSS (6) software. Results: The mean of severity of stress in psoriatic group was higher than control group (P=0.021). On the other hand, there was a relationship between stress and psoriasis expression; but there was no statistically significant correlation between severity of stress and severity of skin lesions in psoriatic patients (P=0.268). Discussion: Paying attention to the effect of stress on the expression of psoriasis, it is suggested to use psychological methods in addition to routine treatment: So we can reduce emotional stress and shorten the course of this disease.
M Asilian Mandegar Fard; Y Dowlati
Volume 2, Issue 2 , 1999, , Pages 45-47
Abstract
A 58-year-old man had 3 years history of asymptomatic, extensive, yellowish patches on his face, neck, trunk and arms. Histopathological examination confirmed the diagnosis of diffuse plane xanthomatosis. This is a rare non-lipemic disease in which xanthomatous lesions develop in the skin in association ...
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A 58-year-old man had 3 years history of asymptomatic, extensive, yellowish patches on his face, neck, trunk and arms. Histopathological examination confirmed the diagnosis of diffuse plane xanthomatosis. This is a rare non-lipemic disease in which xanthomatous lesions develop in the skin in association with paraproteinemia. Serum lipids are usually normal. The histological features include both xanthomatous and inflammatory elements. The treatment of this condition is that of the underlying myeloproliferative disease or paraproteinemia.
P Sepehri; AR Firooz; Y Dowlati
Volume 1, 3-4 , 1998, , Pages 43-46
Abstract
A 47-year-old man with 3 years history of a pruritic plaque, 1×3 cm on his left leg attended a dermatology clinic. An incisional biopsy was done with the differential diagnoses of: 1) Hypertrophic lichen planus, 2) Lichen simplex chronicus, 3) Psoriasis, 4) Bowen's disease. A diagnosis of “Fibroepithelioma” ...
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A 47-year-old man with 3 years history of a pruritic plaque, 1×3 cm on his left leg attended a dermatology clinic. An incisional biopsy was done with the differential diagnoses of: 1) Hypertrophic lichen planus, 2) Lichen simplex chronicus, 3) Psoriasis, 4) Bowen's disease. A diagnosis of “Fibroepithelioma” was suggested by histopathologist who was not compatible with clinical diagnosis. Careful review of slide showed that the specimen had been cut horizontally in the laboratory, which had misled the pathologist. By vertical sectioning the block and doing another biopsy, the diagnosis of hypertrophic lichen planus was confirmed. The patient was treated with intralesional triamcinolone injection and 4 weeks later the lesion was completely healed with residual hyperpigmentation.