Kamran Balighi; Zahra Ghodsi; Masoud Iravani; Maede Rayati Damavandi; Azadeh Goodarzi; Vahide Lajevardi; Sara Saburi; Alireza Faghihi Kashani
Volume 19, Issue 1 , 2016, , Pages 21-24
Abstract
Background: Chronic graft versus host disease (cGVHD) is a major cutaneous complication of bone marrow transplantation (BMT). Although milder forms of this process may be associated with a lower incidence of tumor recurrences, it is mandatory to develop a more efficient and less harmful therapeutic approach.Methods: ...
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Background: Chronic graft versus host disease (cGVHD) is a major cutaneous complication of bone marrow transplantation (BMT). Although milder forms of this process may be associated with a lower incidence of tumor recurrences, it is mandatory to develop a more efficient and less harmful therapeutic approach.Methods: This case-series study enrolled 7 patients diagnosed with chronic mucocutaneous GVHD. We divided the patients into three major categories based on the type of skin lesions: sclerodermoid, lichenoid, and mixed. Patients received several packs of narrow band UVB (NBUVB) phototherapy. Each pack contained ten sessions of NBUVB (311 nm) with a duration of at least ten seconds and a fixed radiation dosage (6 mj/cm2) during the treatment.Results: There were 3 patients diagnosed with lichenoid skin lesions, 2 with sclerodermoid lesions, and 2 had mixed cGVHD lesions. During the follow up period one patient was excluded due to a lower respiratory tract infection. The mean response ratio was 42% with a mean satisfaction level of 5.5 out of 10. The lichenoid group had the best, most rapid response. There were no serious adverse effects reported.Conclusion: Narrow band UVB phototherapy is useful as an adjuvant therapeutic modality in cutaneous lichenoid and intraoral cGVHD with no serious adverse effects.
Mona Abdolreza; Vahide Lajevardi; Kamran Balighi; Kambiz Kamyab; Zahra Naraghi; Soroush Daklan
Volume 15, Issue 1 , 2012, , Pages 26-28
Abstract
A 25-year-old woman referred to our department with a lesion in the anterior part of her neck (Figure 1) since childhood. She complained of a clear discharge from the lesion which increased with pressure. Two years ago, the lesion was treated with electrosurgery but relapsed a few months later. Examination ...
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A 25-year-old woman referred to our department with a lesion in the anterior part of her neck (Figure 1) since childhood. She complained of a clear discharge from the lesion which increased with pressure. Two years ago, the lesion was treated with electrosurgery but relapsed a few months later. Examination revealed an erythematous papule in the anteriorinferior part of the neck with a clear mucoid discharge from its orifice upon pressure. Physical exam was otherwise normal. The patient had no other medical problems. She had never taken any medications. There was no family history of a similar problem. We advised the patient to be visited for excisional biopsy of the lesion.
Amirhooshang Ehsani; Pedram Noormohammadpour; Kamran Balighi; Narges Ghandi; Parisa Dabirvaziri; Sahar Azizahari
Volume 12, Issue 3 , 2009, , Pages 74-78
Abstract
Background: Ingrown toe nail (IGTN) is a painful condition in which the distal-lateral corner of the nail grows into its surrounding soft tissue leading to inflammation and infection. Failure of conservative therapy is an indication for surgical interventions. The aim of this study is to compare matricectomy ...
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Background: Ingrown toe nail (IGTN) is a painful condition in which the distal-lateral corner of the nail grows into its surrounding soft tissue leading to inflammation and infection. Failure of conservative therapy is an indication for surgical interventions. The aim of this study is to compare matricectomy by curettage with chemical matricectomy with phenol 88% in terms of post procedure remission and complications.Methods: A number of 18 patients with IGTN were selected and divided randomly into 9-subject groups. The first group underwent matricectomy by curettage and the second underwent chemical matricectomy with phenol 88%. Patients were assessed after 2, 7 days and 1, 4 months after surgery for pain, oozing, soft tissue inflammation, cellulitis or purulent discharge and recurrence in both of the groups and the results were statistically compared.Results: On the third post procedure day, pain and oozing discharge occurred less in curettage group with significant difference (P = 0.016 and 0.009). In our next visit, one week after procedure, there was no significant difference in recovery and post procedure complications (P = 0.475). In our visit, 4 weeks after procedure, all cases in both groups were completely healed for all parameters and no complication was found.Conclusion: Curettage partial matricectomy is superior to phenol matricectomy in achieving earlier release of post procedure symptoms and complete recovery.
Kamran Balighi; Fatemeh Moeineddin; Ahmadreza Rajaee
Volume 10, Suppl.2 , 2007, , Pages 7-7
Abstract
All member of family referred to our clinic complaining of white nails. Physical examination revealed clinical features of leukonychia totalis and also the presence of sensor ineural hearing loss (SNHL), palmoplantar keratoderma (PPK) and knuckle pads, the four essential criteria for the diagnosis of ...
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All member of family referred to our clinic complaining of white nails. Physical examination revealed clinical features of leukonychia totalis and also the presence of sensor ineural hearing loss (SNHL), palmoplantar keratoderma (PPK) and knuckle pads, the four essential criteria for the diagnosis of Bart Pumphrey syndrome. Three generations were affected with variable presentations in male and female and autosomal dominant pattern of inheritance.
Kamran Balighi; Fatemeh Moeineddin; Ahmadreza Rajaee; Azita Nikoo; Mostafa Mahdavi-nia
Volume 10, Suppl.2 , 2007, , Pages 12-12
Abstract
Mycosis fungicides (MF), on extremely rare occasions, can be associated with vesiculobullous eruptions. We describe a 74-year-old man with previous documented histopathologic diagnosis of poikilodermic type of MF who recently developed some flaccid acral bullae on erythemoatous MF plaque and normal skin. ...
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Mycosis fungicides (MF), on extremely rare occasions, can be associated with vesiculobullous eruptions. We describe a 74-year-old man with previous documented histopathologic diagnosis of poikilodermic type of MF who recently developed some flaccid acral bullae on erythemoatous MF plaque and normal skin. Histopathology and direct immunoflourscence studies revealed extensive lichenoid changes with intraepidermal bulla. Atypical lymphocyte infiltration was presented in dermoepidermal junction and bulla fluid and peripheral blood smear, but absent in lymph node and bone narrow tissue specimens. The plausible cause of blister formation in cutaneous lymphoma bullosa may be due to excessive epidermotropism or toxic effects of cytokines secrected by the tumoral infiltrate.
Ramin Espandar; Kamran Balighi; Shideh Yazdanian; Mahmoud Farzan
Volume 10, Issue 1 , 2007, , Pages 74-77
Abstract
Localized morphea is a disorder of unknown cause in which there is localized sclerosis of the skin. Disabling pansclerotic morphea of childhood is a rare severe mutilating form of morphea involving the dermis, fat, fascia, muscle and even bone, usually starting before the age of 14 years. Here, an eight-year-old ...
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Localized morphea is a disorder of unknown cause in which there is localized sclerosis of the skin. Disabling pansclerotic morphea of childhood is a rare severe mutilating form of morphea involving the dermis, fat, fascia, muscle and even bone, usually starting before the age of 14 years. Here, an eight-year-old boy with progressive sclerosis of palmar surface of wrist and hand and digits without involvement of finger tips is presented whose major signs was flexion contracture of wrist and claw hand deformity of third and fourth fingers. Due to progressive nature of the disease he was treated with prednisolone and hydroxychloroquine and the progression of the disease was controlled.