Yalda Nahidi; Naser Tayyebi Meibodi; Farahnaz Abdolhosseinzadeh; Mostafa Izanlu; Sima Davoodi
Abstract
Background: Psoriasis is a chronic inflammatory skin disease with extensive systemic effects. The role of sex hormones in the pathogenesis of psoriasis remains unknown. Therefore, in this study, the level of sex hormones in male chronic plaque psoriasis patients was evaluated.Methods: This study was ...
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Background: Psoriasis is a chronic inflammatory skin disease with extensive systemic effects. The role of sex hormones in the pathogenesis of psoriasis remains unknown. Therefore, in this study, the level of sex hormones in male chronic plaque psoriasis patients was evaluated.Methods: This study was descriptive-analytic of the cross-sectional type, done with a total population of 60, including 30 patients with chronic plaque psoriasis and 30 healthy subjects in the control group. Serum levels of testosterone, estradiol, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were measured in patients and the control group who did not have psoriasis. The two groups were matched based on the grouped matching technique. The two groups were matched for age (34 ± 9 years) and BMI (30 ± 3 kg/m2), and the effects of these two variables on hormonal levels were eliminated. According to the results of the Kolmogorov-Smirnov test, the data had a normal distribution. The independent t-test and Pearson correlation coefficient were used for data analysis. A P-value less than 0.05 was considered significant.Results: The levels of LH and FSH were significantly higher in the patient group than in the healthy group (P = 0.01 and P < 0.001, respectively). Testosterone and estradiol serum levels were lower in the patient group than in the healthy group (P < 0.001).Conclusion: Our study suggests that male patients with chronic plaque psoriasis have higher levels of LH and FSH and lower levels of testosterone and estradiol than the general male population.
Yalda Nahidi; Bita Kiafar; Zohre Sadeghinejad; Lida Jarahi; Tahmineh Mallakifard
Abstract
Background: Psoriasis is a disease that influences the physical, psychological, and social dimensions of the lives of those affected. We aimed to evaluate the effect of psoriasis disease on the quality of life of patients and their partners.Methods: Forty psoriasis patients were eligible for inclusion ...
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Background: Psoriasis is a disease that influences the physical, psychological, and social dimensions of the lives of those affected. We aimed to evaluate the effect of psoriasis disease on the quality of life of patients and their partners.Methods: Forty psoriasis patients were eligible for inclusion in this study. Each participant’s clinical data were collected, including age, sex, PASI score, history of treatment, family history of the disease, educational level of the patients and their spouse, profession, and history of divorce. The patients and partners completed the Dermatology Life Quality Index (DLQI) and Family Dermatology Life Quality Index (FDLQI) questionnaires, respectively. The results were compared against 40 age and sexmatched healthy individuals and their partners.Results: The mean DLQI score was 11.75 ± 7.25 among patients, and the mean FDLQI score of their partners was 12.20 ± 5.63. There was a significant difference between the patients/partners and the respective control groups in DLQI and FDLQI scores (P < 0.001). There was a significant correlation between disease severity and DLQI/FDLQI scores (P < 0.05). Also, a meaningful relationship was noted between the quality of life of patients and their spouses (r = 0.48, P = 0.001). Besides, the PASI score shared a significant relationship with the DLQI (P = 0.003, r = 0.46) and FDLQI (P = 0.001, r = 0.56) scores.Conclusion: We conclude that psoriasis harms the quality of life of both patients and their families, which deteriorates with an increase in disease severity and PASI scores.
Yalda Nahidi; Naser Tayyebi Meibodi; Habiballah Esmaeili; Zahra Tafazzoli
Abstract
Background: Basal cell carcinoma (BCC) is the most common type of skin tumor. Surgical removal has remained the gold standard of treatment for BCC, but incomplete removal is an important clinical challenge. The goal of our study was to evaluate the incomplete excision of BCC and the factors affecting ...
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Background: Basal cell carcinoma (BCC) is the most common type of skin tumor. Surgical removal has remained the gold standard of treatment for BCC, but incomplete removal is an important clinical challenge. The goal of our study was to evaluate the incomplete excision of BCC and the factors affecting it.
Methods: In this retrospective study, 361 histological samples of BCC excisions referred to the Pathology Department of Imam Reza Hospital, Mashhad, Iran, from 2004 to 2018 were reviewed. Data including age, gender, tumor site, size, histopathologic subtype, surgical margin involvement, and the surgeon’s specialty were recorded.
Results: The incomplete removal rate was 20%. Ten percent of the lesions had deep margin involvement, 5.8% had lateral margin involvement, and both margins were involved in 4.2% of cases. Incomplete excision had a significant relationship with the following variables: nodular, mixed, and sclerosing types; the 60-70 years age group; lesions larger than 2 cm, location in nose and canthi; and excision by an otorhinolaryngologist, ophthalmologist, or dermatologist.
Conclusion: In this study, the frequency of incomplete excision was relatively high compared with other studies. Therefore, it is suggested to perform a diagnostic biopsy before the complete excision of BCC. Excision with a wider margin or using Mohs surgery is recommended for midface lesions, older individuals, nodular, mixed, or sclerosing lesions, and for tumors larger than 2 cm.
Yalda Nahidi; Elahe Abdali; Masoud Maleki; Azadeh Saki; Pouran Layegh
Abstract
Background: Striae is a common condition that is relatively difficult to treat. Recently, carboxytherapy was proposed as a treatment modality. This study aimed to evaluate the therapeutic effect of carboxytherapy in patients with striae.
Methods: This was a pilot clinical study. Patients were treated ...
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Background: Striae is a common condition that is relatively difficult to treat. Recently, carboxytherapy was proposed as a treatment modality. This study aimed to evaluate the therapeutic effect of carboxytherapy in patients with striae.
Methods: This was a pilot clinical study. Patients were treated with 10 sessions of carboxytherapy every week. The patients were photographed at the onset of the treatment course, before each treatment session, and three months after the last ones. Two dermatologists compared the images of each patient before and three months after treatment and evaluated the treatment response based on the following scores: I, no improvement (0%);II, poor (1% to 25%); III, fair (26% to 50%); IV, good (51% to 75%); and V, excellent improvement (76% to 100%). Furthermore, patients’ satisfaction with therapy outcome was recorded on a scale of 0 to 10.
Results: 15 patients were enrolled in this study; 2 (13.4%) were male and 13 (86.6%) were female. Three patients (20%) showed good response, one (6.7%) had a relatively good response, two showed (13.3%) poor response, and seven (46.6%) had no response to treatment. Analysis of the association of carboxytherapy outcomewith different patients’ characteristics showed no statistically significant correlation (P > 0.05).
Conclusions: Although carboxytherapy therapy did not result in a significant response in the majority of our patients, it is somehow capable of improving the striae in some patients. Further studies with bigger sample sizes may be required to ensure the efficacy of this modality in the treatment of striae.
Vahid Mashayekhi Goyonlo; Hossein Hassan Abadi; Hanieh Zandi; Jamshid Jamali; Yalda Nahidi; Ahmad Reza Taheri; Bita Kiafar
Abstract
Background: The treatment of cutaneous leishmaniasis has long been a challenge. The application of heat to the lesions has been described in some studies, with no consensus regarding the types of thermotherapy and their practical implications.We sought to evaluate the efficacy of infrared thermotherapy ...
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Background: The treatment of cutaneous leishmaniasis has long been a challenge. The application of heat to the lesions has been described in some studies, with no consensus regarding the types of thermotherapy and their practical implications.We sought to evaluate the efficacy of infrared thermotherapy in the treatment of cutaneous leishmaniasis. Methods: We evaluated the results of infrared thermotherapy in 35 cutaneous leishmaniasis patients (53 lesions) who attended the leishmaniasis clinic of Imam Reza Hospital, Mashhad, Iran. Three times a week, the lesions were warmed to 45 degrees centigrade for two cycles of 10 minutes. Treatment outcomes were classified as complete (90-100%), good (50-89%), and poor responses (less than 50% size reduction). Results: Thirteen (24.5%) lesions were cured after three months; 31 (58.5%) and 9 (17%) lesions showed good and poor responses, respectively. Treatment outcomes were significantly related to the number of treatment sessions (P ≤ 0.05). No significant side effects were seen. Conclusion: Infrared thermotherapy is a relatively effective and well-tolerated treatment for cutaneous leishmaniasis.
Yalda Nahidi; Vahid Mashayekhi Goyonlo; Pouran Layegh; Hoda Marhamati; Mona Najaf Najafi
Abstract
Background: Zinc is an effective factor in the immune response against infectious agents; its effect on the course of cutaneous leishmaniasis (CL) is unknown. This study aimed to compare the serum zinc level in patients with acute and chronic CL. Methods: A descriptive study was conducted on 120 CL cases ...
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Background: Zinc is an effective factor in the immune response against infectious agents; its effect on the course of cutaneous leishmaniasis (CL) is unknown. This study aimed to compare the serum zinc level in patients with acute and chronic CL. Methods: A descriptive study was conducted on 120 CL cases and controls. This included 30 cases of acute CL (less than one year of lesion recovery), 30 cases of chronic CL (period of illness over one year), and 60 healthy subjects with age and gender proportional to the patients. Volunteers entered the study with knowledge and consent. The serum zinc level was measured by atomic absorption spectrophotometry. Results: The percentages of people with reduced serum zinc levels in the healthy, acute, and chronic groups were 13.3, 50, and 43.3%, respectively, whereby there was a significant difference between the leishmaniasis groups (acute and chronic) and the control group (p <0.001). However, the mean serum zinc level did not differ significantly between the acute (75.36 ± 15.72 µg/dl) and chronic (73.96 ± 17.98 µg/dl) leishmaniasis groups (P=0.94). Conclusions: A reduced serum zinc level is associated with symptomatic CL, but does not affect the clinical outcome and recovery.
Yalda Nahidi; Naser Tayyebi Meibodi; Amir Hossein Jafarian; Habibollah Esmaily; Elham Pishnamaz
Abstract
Background: Radiation-induced basal cell carcinoma (BCC) can be multiple, large, and recurring, which complicates its treatment in some cases. According to reports on the role of cyclooxygenase 2 (COX2) inhibitors in the treatment or prevention of non-melanoma skin cancers and considering ...
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Background: Radiation-induced basal cell carcinoma (BCC) can be multiple, large, and recurring, which complicates its treatment in some cases. According to reports on the role of cyclooxygenase 2 (COX2) inhibitors in the treatment or prevention of non-melanoma skin cancers and considering the fact that COX2 expression has not been evaluated in radiation-induced basal cell carcinoma, weset out to assess the expression of COX2 in these lesions. Methods: In this study, COX2 expression was assessed by immunohistochemistry using anti-COX2 antibody on paraffinembedded blocks of 86 patients referred to Emam Reza Hospitalin Mashhad with BCC diagnosis by pathological examination (43 patients with and 43 without a history of radiotherapy) followed by semi-quantitative evaluation of COX2. Results: In our study, COX2 expression score was significantly higher in patients with a history of radiotherapy than those without radiotherapy (P<0.001). No correlation was found between theintensity and percentage of staining with sex, age, site of lesion, recurrence, and pathology of the tumor. Conclusion: Given the higher expression level of COX2 in the radiation-induced BCC patients, the use of COX2 inhibitors in these individuals may be effective in the incidence, recurrence, or treatment of BCC.
Pouran Layegh; Mohammad Reza Kalantari; Amir Omidvar-Borna; Yalda Nahidi
Volume 10, Suppl.2 , 2007, , Pages 10-10
Abstract
Mycosis fungoides is a common form of cutaneous T-cell lymphoma, with characteristic histopathology and chronic clinical course. Vesiculobullous mycosis fungoides is a rare occurrence. Here we present a 55-year-old man with multiple bullous plaques of one year duration who was finally diagnosed as a ...
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Mycosis fungoides is a common form of cutaneous T-cell lymphoma, with characteristic histopathology and chronic clinical course. Vesiculobullous mycosis fungoides is a rare occurrence. Here we present a 55-year-old man with multiple bullous plaques of one year duration who was finally diagnosed as a case of mycosis fungoides.
Naser Tayebi-Meybodi; Zari Javidi; Habib-Allah Esmaili; Yalda Nahidi
Volume 10, Issue 2 , 2007, , Pages 135-141
Abstract
Background and aim: The stroma of basal cell carcinoma (BCC) is rich in mast cells. Morpheaform BCC has been reported to contain much more mast cells than the other types of BCC, but their significance remains unknown. In this study we investigated the significance of mast cells related to BCC and possible ...
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Background and aim: The stroma of basal cell carcinoma (BCC) is rich in mast cells. Morpheaform BCC has been reported to contain much more mast cells than the other types of BCC, but their significance remains unknown. In this study we investigated the significance of mast cells related to BCC and possible relationship between increased number of mast cells and clinical and histological parameters including the patient's age, sex, subtype of BCC and severity of peritumoral inflammation.Materials and methods: In this retrospective study, a total of 50 BCC specimens either biopsied or excised were examined histologically. H & E stained slides were examined under light microscopy and the severity of inflammation was assessed subjectively and graded as mild, moderate or severe. Then biopsy specimens were stained with Giesma to identify mast cells. Clinical data including sex and age were obtained form patients records. Finally the data were analysed by t test, Mann-Whitney and ANOVA by SPSS software and pConclusion: Our results support previous reports indicating that mast cells may have a contributory role in defining the subtype of BCC and degree of its aggressiveness. It seems that mast cells have a preventive role against aggression of BCC, as we found more mast cells in superficial BCC than deep ones.
Vahid Mashayekhi Guyunlou; Nasser Tayyebi Meybodi; Zari Javidi; Mahmoud Farhoudi; Yalda Nahidi
Volume 9, suppl.1 , 2006, , Pages 10-10
Abstract
Ehlers-Danlos syndrome (EDS) is a heterogenous group of inherited disorders of connective tissue characterized by fragility of the skin and blood vessels, hyperextensibility of the skin and joint hypermobility. Cutis laxa is characteized clinically by lax, pendulous skin and histologically by loss of ...
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Ehlers-Danlos syndrome (EDS) is a heterogenous group of inherited disorders of connective tissue characterized by fragility of the skin and blood vessels, hyperextensibility of the skin and joint hypermobility. Cutis laxa is characteized clinically by lax, pendulous skin and histologically by loss of elastic tissue in the dermis. There are some reports of coexistence of cutis laxa with other disorders. We present a case of classic EDS with cutis laxa in an Iranian family.
