Abbas Darjani; Ehsan Aboutaleb; Narges Alizadeh; Rana Rafiei; Kaveh Gharaee Nejad; Sahar Nabatchii; Elahe Rafiei; Zahra Atrkar Roushan; Hojat Eftekhari
Abstract
Background: Acne vulgaris is a common skin disease. Choosing an appropriate treatment modality is important. We compared benzoyl peroxide 5% gel vs. new topical dapsone 5% gel in combination with doxycycline to improve acne.Methods: In a clinical trial, 60 cases with acne vulgaris aged 18-25 years were ...
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Background: Acne vulgaris is a common skin disease. Choosing an appropriate treatment modality is important. We compared benzoyl peroxide 5% gel vs. new topical dapsone 5% gel in combination with doxycycline to improve acne.Methods: In a clinical trial, 60 cases with acne vulgaris aged 18-25 years were divided randomly into two groups, DD (dapsone 5% gel plus oral 100 mg doxycycline) and BD (benzoyl peroxide 5% gel plus oral 100 mg doxycycline). Topical dapsone 5% gel was made for the first time at Guilan University of Medical Sciences. The lesion counts, side effects, and acne severity (GAAS) were examined at baseline, 2, 4, 8, and 12 weeks. Satisfaction and improvement were assessed after 12 weeks. The Mann-Whitney, chi-squared, Wilcoxon, and Friedman tests were used for statistical analysis in SPSS v. 21.Results: Inflammatory and non-inflammatory lesions were similar between the groups. Lesions were reduced within groups (P > 0.05). GAAS scores were similar between groups but decreased in both groups after 12 weeks (P = 0.003). Side effects (especially skin dryness) were less in the BD group after 12 weeks (P = 0.017), though erythema and skin irritation were less in the DD group (P > 0.05). Both groups reported a similar improvement rate (85%). However, satisfaction was more in the DD group (78%).Conclusion: The new dapsone 5% gel seems to be as effective as benzoyl peroxide 5% in combination with doxycycline. Considering its good tolerability, safety, and acceptability, it is suggested as an appropriate treatment for moderate acne vulgaris. (Clinical trial number: IRCT2017072035195N1)
Narges Alizadeh; Javad Golchai; Atefeh Ghanbari; Behrooz Golchai; Shirin Zaresharifi
Abstract
Background: Anogenital warts are the most prevalent sexually transmitted disease worldwide and are caused by human papillomavirus (HPV). There are more than 100 different types of HPV, of which certain types make the patient more susceptible to malignant neoplasms. This study aimed to determine the frequencies ...
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Background: Anogenital warts are the most prevalent sexually transmitted disease worldwide and are caused by human papillomavirus (HPV). There are more than 100 different types of HPV, of which certain types make the patient more susceptible to malignant neoplasms. This study aimed to determine the frequencies of specific types of HPV in anogenital warts.
Methods: This study included 157 patients diagnosed with anogenital warts that underwent HPV DNA detection using polymerase chain reaction (PCR) with INNO-LiPA genotyping assay.
Results: Of 157 patients with anogenital warts, 122 samples (77.7%) were positive for HPV, with some patients showing mixed HPV subtypes. HPV 6 (n = 99; 68.3%) and HPV 11 (n = 13; 8.9%) were the most prevalent types. 101 patients were male (64.3%). The mean age was 32.02 ± 10.06 years (range: 2 to 72 years). Most patients were infected with the low-risk types (80%); the high-risk HPV type 16 was significantly more common among women (P = 0.0001).
Conclusion: This study showed the higher relative frequency of HPV6 and HPV11 in anogenital warts in Guilan, northern Iran. The frequency of genital HPV infection appears to be higher among men, but the frequency of high-risk types seems to be higher among women.
