Maryam Khalili; simin Shamsi Meymandi; Saman Mohammadi; Mahin Aflatoonian; Elahe Kooshesh
Abstract
Background: Granulomatous skin lesions are characterized by aggregation of activated histiocytes. Granulomatous skin lesions are classified as xanthomatous, necrobiotic, tuberculoid, sarcoidal, and foreign body types. This study evaluates the clinicopathological features of patients with granulomatous ...
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Background: Granulomatous skin lesions are characterized by aggregation of activated histiocytes. Granulomatous skin lesions are classified as xanthomatous, necrobiotic, tuberculoid, sarcoidal, and foreign body types. This study evaluates the clinicopathological features of patients with granulomatous skin lesions.Methods: We conducted a cross-sectional study of 232 skin biopsies diagnosed as granulomatous skin lesions over ten years from patients referred to Afzalipour Hospital, Kerman, Iran. Demographics, clinical features of lesions, and pathological characteristics were recorded. Then, the correlation of the final diagnosis with the demographic and clinical features of the patients was assessed via the independent t-test and chi-squared test.Results: Most patients were in their third decade of life, with a male-to-female ratio of 1.05 to 1. The most common types of granuloma were tuberculoid (60.3%), necrobiotic (12.5 %), and foreign body type (11.2%). Infectious disease was the most common cause of granulomatous lesions (64.2 %); leishmaniasis constituted approximately 96% of cases. The most common causes of noninfectious granulomatous skin diseases were foreign body granuloma (26.2%), granuloma annulare (23.2%), and xanthogranuloma (12.1%). There was a significant correlation between dermatologic disease type and disease duration (P = 0.024).Conclusion: In the current study, the most common type of granuloma was tuberculoid, followed by necrobiotic and foreign body type granulomas. Infectious diseases were the most common cause of granulomatous skin lesions. Furthermore, the most common granulomatous skin diseases were leishmaniasis, foreign body granuloma, and granuloma annulare. The least common granulomatous skin lesions were sporotrichosis and gout.
Maryam Okhovati; Manzumeh Shamsi Meymandi; Simin Shamsi Meymandi; Sajad Saljoghian
Maryam Khalili; Saman Mohammadi; Mohamadhosein Saeidi; Rezvan Amiri; Amireh Heshmatkhah; Simin Shamsi Meymandi; Mahin Aflatoonian
Abstract
Background: Treatment failure of antimony drugs for anthroponoticcutaneous leishmaniasis (ACL) is rising. Recognizing predictivefactors of unresponsiveness to treatment can substantiallyinfluence better ACL management. The goal of this study wasto investigate predictive factors associated with treatment ...
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Background: Treatment failure of antimony drugs for anthroponoticcutaneous leishmaniasis (ACL) is rising. Recognizing predictivefactors of unresponsiveness to treatment can substantiallyinfluence better ACL management. The goal of this study wasto investigate predictive factors associated with treatment failurein ACL in Kerman, southeast Iran.Methods: This case-control study was conducted retrospectivelyon 2,128 ACL cases in Kerman over ten years from 2011 to 2020.The case group included patients whose lesions failed to resolveafter one treatment course. The control group included thosewhose lesions were cured after one treatment course.Results: Treatment failure was observed in 13.5% of cases (10.7%of systemic therapy and 16.7% of local therapy). No significantdifference was reported between the type of treatment andtreatment failure. The association of treatment failure withwinter-onset (P = 0.001, OR = 1.39, CI = 1.23–1.56), face (P = 0.001,OR = 1.86, CI = 1.38–2.49), ulceration (P = 0.01, OR = 0.51, CI = 0.30–0.85), small diameter (P = 0.005, OR = 0.57, CI = 0.38-0.84) andlong duration of lesions (P = 0.01, OR = 1.57, CI = 1.11–2.21) wasvalidated by multivariate logistic regression analysis.Conclusion: Efficient detection and timely management of ACLcases are essential to reduce resistant cases, as lesions lastinglonger than four months show poor response to treatment.Furthermore, early treatment of facial lesions with systemictherapy is suggested to optimize results and reduce the risk ofdisfiguring scars. Further surveys are required to determine thereason behind more treatment failure in winter-onset lesions.
Maryam Khalili; Simin Shamsi Meymandi; Mahin Aflatoonian; Ali Bagheri
Abstract
Background: Basal cell carcinoma is the most common skin cancer, constituting nearly 80% of non-melanoma skin cancers. In this study, for the first time in Kerman, the clinicopathological features of basal cell carcinoma in patients referred to Afzalipour Hospital were evaluated.Methods: This is a retrospective, ...
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Background: Basal cell carcinoma is the most common skin cancer, constituting nearly 80% of non-melanoma skin cancers. In this study, for the first time in Kerman, the clinicopathological features of basal cell carcinoma in patients referred to Afzalipour Hospital were evaluated.Methods: This is a retrospective, cross-sectional study on 145 skin biopsy samples with a diagnosis of basal cell carcinoma in Afzalipour Hospital, Kerman. Demographic features of patients and clinical and pathologic types of basal cell carcinoma were recorded. Then, the correlation between clinical or histological types with demographic features was evaluated using the chi-squared test.Results: Ninety-four (64.8%) of the cases were male, and the mean age of the patients was 68.12 ± 14.54 (min = 15, max = 101) years. The most and the least common sites of involvement were the nose (35.9%) and trunk (0.7%), respectively. The most common clinical (76.5%) and pathological subtypes (71.03%) were nodular. The least common clinical (6.3%) and pathological types (2.1%) were morpheaform. There was no significant correlation between histopathological or clinical types with demographic features including age and sex. Furthermore, there was no significant correlation between sex and the site of the involvement or age of the patients.Conclusion: In this study, most patients were between 60-79 years of age, and the male-to-female ratio was 1.8 to 1. Nodular and morpheaform types were the most and the least common pathological and clinical types, respectively.
Hamed Zartab; Behzad Iranmanesh; Rezvan Amiri; Simin Shamsi Meymandi
Abstract
Background: Alopecic and aseptic nodule of the scalp (AANS) is a rare entity characterized by the presence of sterile, culturenegative nodules/cysts and areas of non-scarring alopecia.Methods: We describe a case on the vertex of a 26-year-old man with a two-week history of a nodular, moderately-fluctuant, ...
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Background: Alopecic and aseptic nodule of the scalp (AANS) is a rare entity characterized by the presence of sterile, culturenegative nodules/cysts and areas of non-scarring alopecia.Methods: We describe a case on the vertex of a 26-year-old man with a two-week history of a nodular, moderately-fluctuant, alopecic lesion. The patient also had cutis verticis gyrata (CVG).Results: The aspirate culture was negative and histopathologic findings were nonspecific. We also performed a trichoscopy of the lesion. After eight weeks, the patient showed dramatic clinical response to doxycycline and a dose of intralesional corticosteroid.Conclusion: This is the first report of the simultaneous occurrence of AANS and primary essential CVG. AANS is a probably under-reported cause of non-scarring alopecia with a rapid and dramatic response to non-surgical treatment and a generally good prognosis.
Simin Shamsi Meymandi; Manzumeh Shamsi Meymandi; Soodabeh Zandi; Shahriar Dabiri; Mahin Aflatoonian
Volume 14, Issue 2 , 2011, , Pages 42-47
Abstract
Background: Cutaneous leishmaniasis (CL) is a major world problem. Several types of treatment regimens have been suggested. Imiquimod demonstrated a leishmanicidal activity by increasing local cytokine production. The aim of this study was to determine the efficacy of topical 5% imiquimod with cryotherapy ...
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Background: Cutaneous leishmaniasis (CL) is a major world problem. Several types of treatment regimens have been suggested. Imiquimod demonstrated a leishmanicidal activity by increasing local cytokine production. The aim of this study was to determine the efficacy of topical 5% imiquimod with cryotherapy vs. intralesional meglumine antimoniate (MA) in treatment of anthroponotic (dry type) CL. Method: This is a prospective, randomized, open trial study (from Iran) from September 2008 to September 2010, including 50 patients (25 patients in the combined imiquimod and cryotherapy group and 25 patients in the intralesional MA group). Patients were randomly assigned to receive combined cryotherapy biweekly with imiquimod three times per week or intralesional MA weekly until complete cure or up to 12 weeks, whichever earlier. The primary end point was clinical cure, defined as complete re-epitelialization of 100%, complete flattening of induration compared with baseline at weeks 2, 6, 12 and follow up were done 1, 2 and 3 months after complete cure. Results: 50 participants divided into 25 patients in group A and 25 patients in group B completed the study. Complete cure was 65.5% (16/24 patients) in group A and 83.3% (19/23 patients) in group B. No complication was detected in patients treated with MA. Pain and eczematous reaction were detected by 4 patients and local infection in 1 patient treated with imiquimod. Conclusion: Although Meguimine antimoniate seems to be a more effective therapy for cutaneous leishmaniasis, this study revealed no significant difference in clinical response between combination of imiquimod and cryotherapy with intralesional MA in patients with cutaneous leishmaniasis in an endemic area of L. tropica.
