Alireza Ghanadan; Kambiz Kamyab; Ali Nili; Hamidreza Mahmoudi; Vahidehsadat Azhari; Anahita Borzouei; Shirin Taraz Jamshidi
Abstract
Background: Pilomatricoma is a benign skin adnexal neoplasm. Various histological features are observed on microscopic examination. We aimed to evaluate this tumor’s demographic and histological features in detail.Methods: One hundred cases with a diagnosis of pilomatricoma were selected, and demographic ...
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Background: Pilomatricoma is a benign skin adnexal neoplasm. Various histological features are observed on microscopic examination. We aimed to evaluate this tumor’s demographic and histological features in detail.Methods: One hundred cases with a diagnosis of pilomatricoma were selected, and demographic and clinical data were entered into a checklist. The pathology slides were reviewed to confirm the diagnosis. The demographic profile of all patients, including age and gender, primary clinical impression, multiplicity of the tumor, microscopic features, and location of tumoral involvement, were extracted. Qualitative data were summarized using frequencies and percentages. Regarding descriptive analysis, the frequency of each histopathologic feature was calculated.Results: Two groups of patients were identified regarding age. This tumor was more common in males among adult patients, while a female preponderance was seen in those under 18. Most lesions were located on the face (40%), followed by upper (32%) and lower (10%) limbs. In addition to well-known histological features, we observed intraepidermal pilomatricoma in two cases presenting unique histopathologic features. Both showed foci of suprabasal cleft formation, while one showed the Borst-Jadassohn phenomenon. These features, in addition to sebaceous differentiation and acantholysis of ghost cells, were not addressed in previous literature.Conclusion: Understanding the diverse and new histological features of pilomatricoma is necessary for differentiating it from other adnexal and soft tissue tumors.
Kambiz Kamyab Hesari; AliReza Ghanadan; Vahidehsadat Azhari; Shirin Taraz Jamshidi; Reza Amiri; Hamidreza Mahmoudi; Ali Salehi Farid; Ali Nili; Anahita Borzouei; Maryam Daneshpazhooh
Abstract
Background: Lichen planopilaris (LPP) is the most common form of immune-mediated scarring alopecia. We evaluated the histopathologic features of LPP in vertical sections of scalp biopsies and compared findings between the scarring and nonscarring phases of the disease.Methods: From June 2019 to June ...
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Background: Lichen planopilaris (LPP) is the most common form of immune-mediated scarring alopecia. We evaluated the histopathologic features of LPP in vertical sections of scalp biopsies and compared findings between the scarring and nonscarring phases of the disease.Methods: From June 2019 to June 2020, vertically sectioned scalp biopsies of 70 new cases of LPP were examined (H&E) according to North American Hair Research Society criteria. Furthermore, patients were divided into two groups based on either the presence or the absence of vertical fibrous bands, and other histopathological features were compared between these two groups.Results: Characteristic findings of LPP were perifollicular lymphocytic infiltration (97.1%), follicular interface degeneration (60%), and perifollicular plasmacytic infiltration (21.4%). Vacuolar degeneration in the dermo-epidermal junction (38.6%), perifollicular lamellar fibroplasia (67.1%), loss of sebaceous glands (87.1%), perifollicular cleft formation (28.6%), and vertical fibrous tracts (65.7%) were also found. Furthermore, we found a significant correlation between the presence of fibrous tracts with both loss of sebaceous glands (P = 0.005) and the presence of lamellar fibroplasia (P = 0.015).Conclusion: The most common findings in the histopathological examination of LPP slides are perifollicular lymphocytic infiltration and loss of the sebaceous glands. Furthermore, sebaceous gland loss and perifollicular lamellar fibroplasia correlate with the scarring phase of LPP.
Maryam Nasimi; vahide Lajevardi; Hamidreza Mahmoudi; Fatemeh Arbab; Safoura Shakoei
Abstract
Background: Lichen planus (LP) is a chronic inflammatory disease of unknown etiology. There is conflicting data on the link between LP and metabolic syndrome. This study evaluated the association of chronic subtypes of LP, namely oral lichen planus and lichen planopilaris (LPP), with metabolic syndrome.Methods: ...
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Background: Lichen planus (LP) is a chronic inflammatory disease of unknown etiology. There is conflicting data on the link between LP and metabolic syndrome. This study evaluated the association of chronic subtypes of LP, namely oral lichen planus and lichen planopilaris (LPP), with metabolic syndrome.Methods: In this cross-sectional study, 66 patients with oral and follicular LP were evaluated for metabolic syndrome based on the US National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III) criteria and were compared against 66 healthy controls. Waist circumference, body mass index (BMI), systolic and diastolic blood pressure, fasting blood sugar (FBS), and lipid profile were measured for each individual.Results: There was no significant difference in the prevalence of metabolic syndrome (13 [19.7%] vs. 8 [12.1%]; P = 0.23) and dyslipidemia (51 [77.3%] vs. 49 [74.2%]; P = 0.68) between the study groups. These findings remained statistically insignificant in both genders. The waist circumference (P = 0.008) and diastolic blood pressure (DBP) (P = 0.02) were significantly higher in the LP group than the healthy individuals. Our data showed that each unit increment in waist circumference and DBP leads to a 4.1% (P = 0.02) and 4.7% (P = 0.03) increase in the chance of LP,respectively.Conclusion: Patients with oral LP and LPP do not have a higher prevalence of metabolic syndrome or dyslipidemia than healthy individuals. However, they are more vulnerable to central obesity and high diastolic pressure, for which they should be routinely screened.
Leila I Izadi Firouzabadi; Hamidreza Mahmoudi; Ali Khamesipour; Abhay Satoskar; Alireza Firooz
Abstract
Background: Basal cell carcinoma (BCC) is the most common type of skin malignancy. Hyperthermia is used as adjuvant therapy together with radiotherapy and chemotherapy in the treatment of some cancers. This study aimed to evaluate the efficacy and safety of thermotherapy in the treatment of BCCs.
Methods: ...
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Background: Basal cell carcinoma (BCC) is the most common type of skin malignancy. Hyperthermia is used as adjuvant therapy together with radiotherapy and chemotherapy in the treatment of some cancers. This study aimed to evaluate the efficacy and safety of thermotherapy in the treatment of BCCs.
Methods: This pilot trial was carried out on five patients with nodular or superficial BCCs on the scalp and face.Thermotherapy was done at 50° C for a duration of 30 seconds with a radiofrequency device (Thermomed 1.8 thermosurgery technologies). Thermotherapy treatment was applied only in one session. The first follow-up was one week after the procedure and then every month for six months. The last follow-up was one year after the procedure.
Results: All patients showed clearance of the tumors. Blisters, ulcers, crusts, and necrosis were the side effects, which healed with acceptable degrees of scarring. No recurrence was observed at the end of the study.
Conclusion: Thermotherapy was safe and efficacious for the treatment of BCCs on the scalp and face. It should be considered especially for the low-risk subtypes of this cancer.
