Omid Zargari; Seyyede Zeinab Azimi; Seyyed Alireza Mesbah
Abstract
Cutaneous angiosarcoma is a rare tumor of the head and neck region, most commonly affecting the elderly male. Its presentation varies from a small plaque to multifocal nodules. Differentiating this tumor from other conditions, such as hemangiomas, Kaposi sarcoma, squamous cell carcinoma, and rosacea, ...
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Cutaneous angiosarcoma is a rare tumor of the head and neck region, most commonly affecting the elderly male. Its presentation varies from a small plaque to multifocal nodules. Differentiating this tumor from other conditions, such as hemangiomas, Kaposi sarcoma, squamous cell carcinoma, and rosacea, is sometimes difficult. Herein, we present a case of a 73-year-old male with a small oozing lesion on the scalp for more than two months. He had a history of scalp irradiation for tinea capitis in his childhood. Also, he experienced multiple basal cell carcinomas on his scalp a few years ago. Skin biopsy revealed infiltrations of malignant neoplastic lesions composed of proliferated pleomorphic tumoral cells with hyperchromatic nuclei and some epithelioid features arranged as sheets and irregularly shaped vascular spaces mostly devoid of red blood cells. Neoplastic cells were diffuse and strongly positive for D2-40, CD31, CD34, and Ki67 but negative for C-myc and CK. Cutaneous angiosarcoma should be considered in the differential diagnoses of scalp lesions, particularly in older men.
Narges Alizadeh; Seyyede Zeinab Azimi; Somayeh Hoseinzadeh
Abstract
Background: The relationship between body mass index (BMI) and the severity of psoriasis is of debate. We investigated the relationship between BMI and psoriasis area and severity index (PASI) in Northern Iran. Method: In this prospective, observational descriptive study, 190 patients with chronic plaque-type ...
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Background: The relationship between body mass index (BMI) and the severity of psoriasis is of debate. We investigated the relationship between BMI and psoriasis area and severity index (PASI) in Northern Iran. Method: In this prospective, observational descriptive study, 190 patients with chronic plaque-type psoriasis were included from January 2015 to 2017. None of the patients used systemic therapy for psoriasis during the last month. Results: There was a slight female predominance in our study (n=116; 61.1%). The mean age of our patients was 28.88 ± 18.17 (mean ± standard deviation) years. We found a positive correlation between BMI and PASI in the groups of psoriatic patients who had normal weight or were overweight (r = 0.369, P=0.006 and r=0.287, P=0.019, respectively). In the final logistic regression model, it was shown that in cases with BMI<18.5, the mean PASI score was lower in comparison with those with normal BMI (OR = 0.074, CI: 0.009, 0.636). Conclusion: A relationship between BMI and PASI was only seen in psoriatic patients who had normal weight or were overweight. To reduce the effect of factors such as systemic treatments, it is suggested to evaluate the relationship between BMI and PASI score as soon as the diagnosis of psoriasis is confirmed.
Hojat Eftekhari; Seyyede Zeinab Azimi; Abbas Darjani; Rana Rafiei; Melika Amookhteh
Abstract
Background: Psoriasis is a chronic disease that may affect patients’ quality of life. We investigated the quality of life (QoL) and its related factors in psoriasis patients. Methods: In this cross-sectional study, 123 patients with psoriasis vulgaris were enrolled, who were at the ...
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Background: Psoriasis is a chronic disease that may affect patients’ quality of life. We investigated the quality of life (QoL) and its related factors in psoriasis patients. Methods: In this cross-sectional study, 123 patients with psoriasis vulgaris were enrolled, who were at the age of 18-55 years. The QoL was assessed by the psoriasis disability index (PDI) questionnaire. The stress associated with psoriasis was evaluated by the psoriasis life stress inventory (PLSI) questionnaire. The severity of the disease (SoD) was measured based on the psoriasis area and severity index (PASI) score. Results: In this study, the mean age of the patients was 40.77 ± 0.73 years, and the mean duration of the disease was 8.7 ± 8.23 years. The average PASI score was 11.06, and the average PDI score was 11.98. The average PDI and PASI scores of smoker patients were significantly more than those of non-smokers (P = 0.017). There was a strong relationship between all parts of QoL and PLSI scores, as well as between PASI and PLSI (P < 0.05). Conclusions: Psoriasis reduced our patients’ quality of life. Thus, it is recommended that the QoL in psoriatic patients be evaluated. Stress management and psychological supporting methods are necessary for these patients.
