Amirhoushang Ehsani; Alireza Firooz; Arezou Jam Manesh; Amirali Jahanshahi; Elnaz Khosravani; vahide Lajevardi; Parvin Mansouri; Mansour Nassiri Kashani; Reza M Robati; Zahra Saffarian
Abstract
Urticaria is a frequent and difficult-to-treat skin condition, described as temporary erythematous, raised, and itchy skin lesions (wheals) brought on by dilated blood vessels, elevated local blood flow, and increased vascular permeability. It can occur alone or in conjunction with angioedema. Urticaria ...
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Urticaria is a frequent and difficult-to-treat skin condition, described as temporary erythematous, raised, and itchy skin lesions (wheals) brought on by dilated blood vessels, elevated local blood flow, and increased vascular permeability. It can occur alone or in conjunction with angioedema. Urticaria can be diagnosed and treated in fields other than dermatology; patients often visit general physicians, internal medicine specialists, allergologists, and clinical immunologists. In 2018, the Iranian Society of Dermatology produced a clinical practice guideline on diagnosing and managing urticaria. To update the guideline, the Guideline Development Committee conducted an exhaustive search of scientific papers published on the topic from April 2018 to the end of August 2022, and the new guideline was developed. Finally, the updated guideline was critiqued by members of the Dermatology Board Certificate Examination Panel and chairs of dermatology departments in Iran, and it was improved using their feedback.
Saman Ahmad Nasrollahi; Zaynab Variji; Zahra Ghasemi; Somayeh Yadangi; Aniseh Samadi; Alireza Firooz
Abstract
Background: Cellulite is a cosmetic problem, especially in women. We compared the safety and efficacy of a herbal anti-cellulite lotion with a placebo in a randomized, double-blind, right-left comparison clinical trial.Methods: Ten healthy women (22-58 years) with cellulite (grades 2-4) participated ...
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Background: Cellulite is a cosmetic problem, especially in women. We compared the safety and efficacy of a herbal anti-cellulite lotion with a placebo in a randomized, double-blind, right-left comparison clinical trial.Methods: Ten healthy women (22-58 years) with cellulite (grades 2-4) participated in this study. The anti-cellulite lotion and placebo were applied twice daily on the thighs and buttocks for two months. Treated areas were photographed, and the thigh circumference, subcutaneous fat thickness, and dermal echo density were assessed and compared before and after the treatment. The satisfaction of the participants was also assessed.Results: A comparable improvement in cellulite grade was detected by a blinded dermatologist on both treatment sides. Cellulite improved much in one participant, improved in six, and did not change in three participants. The dermis thickness increased compared with placebo after two months (P = 0.046). A significant reduction was observed in subcutaneous fat thickness on the treated side (P = 0.03). However, the decrease was not significant on the placebo site. There was an increase in the echo density of the dermis in the treatment site, though it was not statistically significant. Both products were well tolerated, and none of the participants experienced skin burning or itching.Conclusion: The studied anti-cellulite lotion reduced the thickness of subcutaneous fat and increased the dermis thickness without serious adverse effects.
Saman Ahmad Nasrollahi; Aniseh Samadi; Fatemeh Samii; Chao Yuan; Alireza Firooz
Abstract
Background: Brimonidine tartrate is an alpha-2 adrenergic receptor agonist approved for treating rosacea. This study aimed to assess the efficacy and safety of a brimonidine gel in rosacea patients with skin types III and IV.
Methods: This study was a phase II before-after clinical study in 20 patients ...
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Background: Brimonidine tartrate is an alpha-2 adrenergic receptor agonist approved for treating rosacea. This study aimed to assess the efficacy and safety of a brimonidine gel in rosacea patients with skin types III and IV.
Methods: This study was a phase II before-after clinical study in 20 patients with moderate to severe rosacea treated with brimonidine 0.33% gel. Clinician’s Erythema Assessment (CEA), Patients’ Self-Assessment (PSA), skin erythema (ΔE), lightness (ΔL), and biophysical parameters were measured before treatment and 4 and 8 weeks later. Ultrasound parameters were also measured at the same time points.
Results: Eighteen patients completed the study. CEA and PSA decreased significantly from 3.05 to 2.10 and 2.15 after 4 weeks and 2.20 and 2.15 after 8 weeks, respectively (P<0.01 for both). Furthermore, ΔE and ΔL, as well as the skin erythema index, improved after 4 weeks of treatment. The skin echo density of both the epidermis and dermis also increased after 8 weeks (P<0.05). During the study, no serious adverse events occurred other than some reports of temporary moderate redness.
Conclusion: Daily application of brimonidine 0.33% gel is safe and effective for the treatment of rosacea in darker skin types.
Setareh Ameri; Saman Ahmad Nasrollahi; Aniseh Samadi; Fatemeh Amiri; Solmaz Ahmadvand; Somayeh Yadangi; Mahsa Fattahi; Marzieh Ehsani; Alireza Firooz
Abstract
Background: Hand hygiene plays a vital role in controlling pathogenic microorganisms’ transmission and maintaining the interaction between skin microbiota and biometric parameters. This study evaluated the effects of hand cleansers including alcoholic gel, alcoholic pad, antibacterial, and simple ...
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Background: Hand hygiene plays a vital role in controlling pathogenic microorganisms’ transmission and maintaining the interaction between skin microbiota and biometric parameters. This study evaluated the effects of hand cleansers including alcoholic gel, alcoholic pad, antibacterial, and simple wipes on skin biometric parameters and microbiota.Methods: Samples were collected from the hands of 15 healthy office workers with a mean age of 37.70 ± 9.6 years. Then, the subjects were instructed to use cleansers in four following rounds, with a one-week washout period between the rounds. Sample collection was performed before, right after, and one hour after using the cleansers. Microbial isolates were investigated via standard microbiological techniques, and biometric measurements were made using the Cutometer® MPA 580. The obtained data were analyzed using the paired t-test and repeated measures ANOVA.Results: Overall, there were no significant differences between cleansers in reducing the total aerobic microbial count (TAMC). Also, there was an approximate return to the initial count of resident microbiota one hour after using the alcoholic pad. A significant difference was observed in decreasing the Staphylococcus aureus count using antibacterial wipes rather than simple wipes. Simple wipes had the most increasing effect on transepidermalwater loss (TEWL), showing a significant difference with the alcoholic gel. Furthermore, alcoholic gel caused a greater pH decrease in comparison to other products.Conclusion: Alcoholic cleaners are more effective than antibacterial and simple wipes due to maintaining the skin’s biometric parameters. An additional advantage is that alcoholic pads can preserve the resident microbiota.
Leila I Izadi Firouzabadi; Hamidreza Mahmoudi; Ali Khamesipour; Abhay Satoskar; Alireza Firooz
Abstract
Background: Basal cell carcinoma (BCC) is the most common type of skin malignancy. Hyperthermia is used as adjuvant therapy together with radiotherapy and chemotherapy in the treatment of some cancers. This study aimed to evaluate the efficacy and safety of thermotherapy in the treatment of BCCs.
Methods: ...
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Background: Basal cell carcinoma (BCC) is the most common type of skin malignancy. Hyperthermia is used as adjuvant therapy together with radiotherapy and chemotherapy in the treatment of some cancers. This study aimed to evaluate the efficacy and safety of thermotherapy in the treatment of BCCs.
Methods: This pilot trial was carried out on five patients with nodular or superficial BCCs on the scalp and face.Thermotherapy was done at 50° C for a duration of 30 seconds with a radiofrequency device (Thermomed 1.8 thermosurgery technologies). Thermotherapy treatment was applied only in one session. The first follow-up was one week after the procedure and then every month for six months. The last follow-up was one year after the procedure.
Results: All patients showed clearance of the tumors. Blisters, ulcers, crusts, and necrosis were the side effects, which healed with acceptable degrees of scarring. No recurrence was observed at the end of the study.
Conclusion: Thermotherapy was safe and efficacious for the treatment of BCCs on the scalp and face. It should be considered especially for the low-risk subtypes of this cancer.
