Soheila Nasiri; Niloufar Najar Nobari; Shirin Zaresharifi; Nooshin Zaresharifi
Abstract
B-cell lymphomas represent most non-Hodgkin lymphomas (NHLs) arising within lymph nodes, and about 27% of patients have extranodal involvement. Primary cutaneous lymphoma is defined as malignant lymphoma limited to the skin at diagnosis. Diffuse large B-cell lymphoma (DLBCL) is the most common form of ...
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B-cell lymphomas represent most non-Hodgkin lymphomas (NHLs) arising within lymph nodes, and about 27% of patients have extranodal involvement. Primary cutaneous lymphoma is defined as malignant lymphoma limited to the skin at diagnosis. Diffuse large B-cell lymphoma (DLBCL) is the most common form of NHL, accounting for over one-third of all lymphomas. Primary cutaneous diffuse large B-cell lymphoma (PCDLBCL) is a type of non-Hodgkin’s lymphoma with skin involvement as the first and only site of involvement. Primary cutaneous diffuse large B-cell lymphoma typically presents as a rapid-growing, red or bluish nodule or tumor on the legs, though around 10–15% of patients present with lesions elsewhere. This case report illustrates a rare manifestation of PCDLBCL presenting as a non-healing, rapidly progressive ulcer in the groin area diagnosed based on histopathology and immunohistochemical expression. The patient was treated successfully with systemic chemotherapy. This report could have implications for clinicians to consider the diagnosis of PCDLBCL in patients with unusual, non-healing, chronic ulcers, especially in the elderly, despite the anatomic site of the lesions.
Narges Alizadeh; Javad Golchai; Atefeh Ghanbari; Behrooz Golchai; Shirin Zaresharifi
Abstract
Background: Anogenital warts are the most prevalent sexually transmitted disease worldwide and are caused by human papillomavirus (HPV). There are more than 100 different types of HPV, of which certain types make the patient more susceptible to malignant neoplasms. This study aimed to determine the frequencies ...
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Background: Anogenital warts are the most prevalent sexually transmitted disease worldwide and are caused by human papillomavirus (HPV). There are more than 100 different types of HPV, of which certain types make the patient more susceptible to malignant neoplasms. This study aimed to determine the frequencies of specific types of HPV in anogenital warts.
Methods: This study included 157 patients diagnosed with anogenital warts that underwent HPV DNA detection using polymerase chain reaction (PCR) with INNO-LiPA genotyping assay.
Results: Of 157 patients with anogenital warts, 122 samples (77.7%) were positive for HPV, with some patients showing mixed HPV subtypes. HPV 6 (n = 99; 68.3%) and HPV 11 (n = 13; 8.9%) were the most prevalent types. 101 patients were male (64.3%). The mean age was 32.02 ± 10.06 years (range: 2 to 72 years). Most patients were infected with the low-risk types (80%); the high-risk HPV type 16 was significantly more common among women (P = 0.0001).
Conclusion: This study showed the higher relative frequency of HPV6 and HPV11 in anogenital warts in Guilan, northern Iran. The frequency of genital HPV infection appears to be higher among men, but the frequency of high-risk types seems to be higher among women.