Fatemeh Mohaghegh; Farahnaz Fatemi; Parvin Rajabi; Samaneh Mozafarpoor
Abstract
Primary angioplasmacellular hyperplasia is a scarce clinical dermatologic condition presenting different skin lesions diagnosed through biopsies indicating vascular proliferation with perivascular plasma cell infiltrations. In the current case presentation, a 40-yearold healthy male was referred to our ...
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Primary angioplasmacellular hyperplasia is a scarce clinical dermatologic condition presenting different skin lesions diagnosed through biopsies indicating vascular proliferation with perivascular plasma cell infiltrations. In the current case presentation, a 40-yearold healthy male was referred to our outpatient dermatologic clinic with concurrent limbs and trunk erythematous vascular lesions for five years. The chief complaint of the patient was intermittent pruritus and relative irritation for years. Multiple biopsies were derived from the lesions, and vascular proliferation of capillaries with intensive perivascular infiltration of plasma cells was detected in the pathological specimen that finally led us to the final diagnosis of primary angioplasmocellular hyperplasia. Treatment with isotretinoin was initiated, and the patient responded to the treatment protocol dramatically. Given the rarity of reported cases, this report is considered the first case of primary angioplasmacellular hyperplasia with numerous lesions scattered and the first experience of successful treatment with isotretinoin.
Fariba Iraji; Fatemeh Mohaghegh; Atefeh Shajari; Parvin Rajabi; Samaneh Mozafarpoor
Abstract
Mycosis fungoides (MF) is the most common skin subtype of T-cell lymphoma. Its underlying cause is not yet clearly understood, and diagnosis might be difficult since MF presents itself with symptoms similar to some other dermatologic disorders. In the current case presentation, we report a 12-year-old ...
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Mycosis fungoides (MF) is the most common skin subtype of T-cell lymphoma. Its underlying cause is not yet clearly understood, and diagnosis might be difficult since MF presents itself with symptoms similar to some other dermatologic disorders. In the current case presentation, we report a 12-year-old female with concurrenthypopigmented and pigmented purpuric dermatosis-like lesions that underwent skin biopsies and immunohistochemistry study. Microscopic findings of hyperkeratosis and mild acanthosis in addition to epidermotropism of lymphocytes with perivascular and interstitial infiltration led us to the probable diagnosis of MF.Intraepidermal lymphocyte immunohistochemistry assessments were positive for CD3 and CD4 while negative for CD8 and CD7. The peripheral blood smear revealed a normal CD4 to CD8 ratio, and the number of Sézary cells detected was insufficient to diagnose Sézary syndrome. Therefore, the final diagnosis of MF was made for this young patient.
Ali Asilian; Samaneh Mozafarpoor; Azadeh Goodarzi; Mohammad Amin Jafari; Parvin Rajabi; Mehdi Eftekhari
Abstract
Composite hemangioendothelioma (CHE) is a rare and little-known condition with combined benign, intermediate, and malignant features. In the current study, we describe the case of a young female with the presentations of CHE, representing the second known case in Iran. Also, we have comprehensively reviewed ...
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Composite hemangioendothelioma (CHE) is a rare and little-known condition with combined benign, intermediate, and malignant features. In the current study, we describe the case of a young female with the presentations of CHE, representing the second known case in Iran. Also, we have comprehensively reviewed previous case reports of CHE. A 30-year-old female was referred with a reddish hemorrhagic painless mass in the small right finger that appeared within a few days following trauma. The mass was primarily excised but recurred within three weeks; therefore, she underwent thorough clinical, laboratory, and imaging studies. Finally, the lesions were biopsied and diagnosed as CHE. Accordingly, the involved finger was amputated, and the patient underwent chemoradiotherapy. Although CHE is a rare malignant condition worldwide, attention to the clinical presentations of this malignancy can help scientists make better therapeutic approaches leading to the best outcomes.
