Lajevardi Vahideh; Ghiasi Maryam; Falahati Ali Asghar; Goodarzi Azadeh
Volume 20, Issue 3 , 2017, , Pages 69-74
Abstract
Background: Vitiligo is an acquired skin discoloration with melanocytic destruction. Vitiligo is associated with other autoimmune disorders; hence, an autoimmune etiology is among the most important theories for this disorder. The nails can be involved in numerous cutaneous or systemic non-cutaneous ...
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Background: Vitiligo is an acquired skin discoloration with melanocytic destruction. Vitiligo is associated with other autoimmune disorders; hence, an autoimmune etiology is among the most important theories for this disorder. The nails can be involved in numerous cutaneous or systemic non-cutaneous disorders. We have taken into consideration previous studies on nail abnormalities in vitiligo and alopecia areata (AA), which are ethologically closely-related, in addition to the few, notwell designed studies on nail changes in vitiligo, and lack of similar studies in Iran. This case-control study was conducted to evaluate the autoimmune etiology of vitiligo with a larger number of participants.Methods: In this case-control study, we assessed the nail characteristics of 303 participants at Razi Hospital, Tehran, Iran from 2013-2014. These changes were also assessed in terms of diseases properties of the case group and included distribution, duration, and presence of other concomitant cutaneous disorders.Results: There was a statistically significant odd’s ratio (OR) for leukonychia in the case and control groups. The relationship between the prevalence of leukonychia and disease duration was meaningful (P0.05). There was no other significant difference between each type of nail abnormality in the case and control groups. We observed no association between these abnormalities and disease duration. None of the nail abnormalities, including leukonychia, had an association with distributionpattern of the disorder.Conclusion: Leukonychia was the most common abnormality in nails of vitiligo patients that had a relation to disease duration.
M Karimzadegan Nia; A Miramin Mohamadi; AR Firooz; MR Shidfar
Volume 7, Issue 2 , 2004, , Pages 95-100
Abstract
Background: At present time, the diagnosis of onychomycosis is based on clinical signs, direct exam and fungal culture, whereas Pathologic methods have shown to be more sensitive than other methods. Objective: Evaluation of pathologic methods in the diagnosis of onychomycosis in comparison to direct ...
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Background: At present time, the diagnosis of onychomycosis is based on clinical signs, direct exam and fungal culture, whereas Pathologic methods have shown to be more sensitive than other methods. Objective: Evaluation of pathologic methods in the diagnosis of onychomycosis in comparison to direct smear and culture. Patients and Methods: A nail sample was cut form 96 suspected onychomycosis patients by nail clipper. Then it was divided to four pats, and one part was stored. One part was fixed in 4% formalin and examined pathologically (PATH-PAS method). Another part was cultured in mycosil agar and Sabour and Dextrose Agar media and kept in room temperature for 4 weeks. Another part was directly examined by 10% KOH. The results of each method were recorded separately without knowing the results of others. Clinical signs with at least one positive result were considered as onychomycosis and the sensitivity of these methods were compared. Results: The most sensitive method was the combination of PATH-PAS and direct smear (98%). There was no significant difference between the sensitivity of smear and pathological method, where as PATH-PAS and culture differed significantly. Conclusion: PATH-PAS is a simple and very sensitive method in the diagnosis of onychomycosis.
F Farnaghi; H Seirafi; AR Firooz; F Jamshidi
Volume 7, Issue 1 , 2003, , Pages 19-23
Abstract
Background: Psoriatic arthropathy is a seronegative arthropathy seen in some patients with psoriasis, a self-limited and genetically determined skin disease. Objective: To determine the prevalence and risk factors of arthropathy in patients with psoriasis. Patients and Methods: In a prospective, cross-sectional ...
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Background: Psoriatic arthropathy is a seronegative arthropathy seen in some patients with psoriasis, a self-limited and genetically determined skin disease. Objective: To determine the prevalence and risk factors of arthropathy in patients with psoriasis. Patients and Methods: In a prospective, cross-sectional study, psoriatic patients referred to Razi Skin Hospital in Tehran, Iran in 2002 were evaluated for the presence of arthropathy, and were referred to a rheumatologist for confirmation of arthropathy. The relationship between and nail involvement were evaluated using chi-square and t tests. Results: Among 320 patients with psoriasis, 29 (9.1%) had joint diseases. The most common was asymmetric polyarthritis. Patients with joint diseases had more nail involvement (96.5% vs. 73.1%, P<0.05) and higher mean PASI scores (24.33±10.35 vs. 10.70±8.44, P<0.05) than those without arthropathy, but the age and sex distribution of two groups were not significantly different. Conclusion: The prevalence of joint diseases in psoriatic patients in this study was similar to other reports. Nail involvement and more extensive disease are risk factors for joint diseases in these patients.
K Nabizadeh; A Nasiri; A Zamanian
Volume 5, Issue 1 , 2001, , Pages 20-26
Abstract
Background: The nails of hands and feet are involved in the course of many dermatoses and some systemic diseases. They may have diagnostic or prognostic value in some diseases. Objective: The aim of this study was to evaluate nail lesions in patients referred to Dermatology Department of Sina Hospital ...
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Background: The nails of hands and feet are involved in the course of many dermatoses and some systemic diseases. They may have diagnostic or prognostic value in some diseases. Objective: The aim of this study was to evaluate nail lesions in patients referred to Dermatology Department of Sina Hospital in Hamadan from April 1999 to April 2000. Patients and Methods: This cross-sectional descriptive study was done by preparation of a checklist and necessary information was collected by examining all the patients and recording the nail changes. The data were analyzed with EP16 software. Results: Among 2269 patients visited during this year, 630 persons (27.7%) had nail lesions. Eczema and psoriasis were the most common dermatosis with nail lesions (23.5% and 12%, respectively). Fifty-five patients (8.7%) had only nail diseases. Ridging was the most common nail lesion in hands (32%) and in feet (42%). Conclusion: Approximately one third of patients referred to the dermatologic clinic of Sina Hospital in Hamadan had nail lesions.