Hossain Kawosi; Nader Salari; Arash Golpazir Sorkhe; Ibrahim Shakiba; Roya Safarpour; Masoud Mohammadi
Abstract
Background: Malignant melanoma is a prevalent, offensive, andfatal cancer in developed countries. Most of our information isrelated to studies conducted in western countries. This studyaims to evaluate demographic and clinical data of melanoma inthe Kermanshah province of Iran.Method: This was a descriptive ...
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Background: Malignant melanoma is a prevalent, offensive, andfatal cancer in developed countries. Most of our information isrelated to studies conducted in western countries. This studyaims to evaluate demographic and clinical data of melanoma inthe Kermanshah province of Iran.Method: This was a descriptive study on data available in theCancer Registry Center of Kermanshah, which includes 70patients during eight years from 2010–2017. Clinical recognitionof melanoma was based on American Joint Committee on Cancercriteria. Data were analyzed by SPSS 20 software and shown inArcGIS (Version 10.7).Results: Patients included 46 men (65.7%) and 24 women (34.3%)with a mean age of 60.49 ± 16.08. The general prevalence ofmelanoma was 4.4 in every 1,000,000 persons annually. Mostpatients had skin type III (65.7%), indoor jobs (61.4%), and livedin the city (67.1%). Also, 35.7% had a trauma history, 2.8% hadfamilial melanoma history, and 17.1% had other types of skincancer. Extremities (51.4%), acral lentiginous melanoma (50.1%),Clark IV (61.4%), and inguinal lymph nodes (14.3%) were themost prevalent location, clinical type, pathological level, andinvolved lymph nodes, respectively.Conclusion: Acral lentiginous melanoma and extremitiesinvolvement are prevalent in our region. Most patients go todoctors at an advanced level due to delays in referral, lack offollow-up by patients, lack of recognition at the initial care level,and lack of access to specialty centers. We recommend generalinstructions through media and holding special workshops forphysicians for better familiarity with melanoma.
Behnam Avandi; Mehdi Ghahartars; Navid Moradi Kashkooli; Najmeh Ahramiyanpour; Mohammad Mahdi Parvizi
Abstract
Erythroderma or generalized scaling dermatitis is a condition marked by redness and scaling of more than 90% of the body surface. This study aimed to review the epidemiological and clinical features of erythroderma patients hospitalized in the Dermatology Ward of Shahid Faghihi Hospital, Shiraz, Iran. ...
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Erythroderma or generalized scaling dermatitis is a condition marked by redness and scaling of more than 90% of the body surface. This study aimed to review the epidemiological and clinical features of erythroderma patients hospitalized in the Dermatology Ward of Shahid Faghihi Hospital, Shiraz, Iran. This retrospective cross-sectional was conducted from 2001 to 2017 using patient records. All patients with a diagnosis of erythroderma on record were included in the survey, and those whose data were missing or were not compatible with the clinical diagnosis were excluded. Data were analyzed with SPSS version 22 and Stata version 14.2. Overall, 217 erythroderma patients were admitted to this ward, including 119 (54.8%) men and 98 (45.2%) women. The mean age of the patients was 47.27 ± 19.68 years (range: 4-92 years). Moreover, the most frequent cause of erythroderma was drug reaction (67%); lamotrigine, with a frequency of 12 patients, was the most prevalent prescribed medication in patients with drug reaction-induced erythroderma. The mean duration of hospital stay was 6.64 ± 4.50 days; this parameter was directly associated with the erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) level. Pruritus (41.9%) and fever (15.2%) were the most frequent clinical manifestations among these patients. As erythroderma is a dermatologic condition that medications can induce, patients should be informed about the warning signals and course of the disease before certain medications are prescribed.
Maryam Zahed; Ladan Dastgheib; Maryam Sadat Sadati; Asma Soukhakian
Abstract
Background: Pemphigus vulgaris (PV) is a life-threatening autoimmune disease that affects the skin and mucosa. In most regions, little data is available on its epidemiology. This study aimed to present an overview of the worldwide epidemiology of pemphigus and evaluate the epidemiological features of ...
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Background: Pemphigus vulgaris (PV) is a life-threatening autoimmune disease that affects the skin and mucosa. In most regions, little data is available on its epidemiology. This study aimed to present an overview of the worldwide epidemiology of pemphigus and evaluate the epidemiological features of PV in the southwest of Iran.Methods: In this study, data including sex, age, time of disease onset, phenotype of the disease, geographic location of birth, geographic location of residence, level of education, and occupation of PV patients from 2004 to 2019 were collected from the records existing in the Oral Medicine Department of Shiraz Dental School and Shahid Faghihi Hospital, Shiraz, Iran.Results: In total, 249 PV patients with a mean age of 42.72 ± 13.3 years were included. The female to male ratio was 1.74:1. The annual incidence of PV in Fars province was 2.7 per million people. In this region, the most frequent phenotype was the mucocutaneous phenotype in 204 patients (81.9%), followed by the mucosal dominant phenotype in 40 (16.1%) and the cutaneous phenotype in 5 (2%). Regarding the level of education, 43.4% had less than a high school diploma, 24.9% had a high school diploma, 17.3% had an associate diploma or higher, and 14.5 % were illiterate. Moreover, 55.8% were housewives, 21.7% were self-employed, 19.3 % were employed, and 3.2% were jobless.Conclusion: The findings indicate that PV is a rare disease in the southwest of Iran compared with other regions. According to previous studies in this region, the incidence has decreased since 2005.
Dastgheib Ladan; Saki Nasrin; Heiran Alireza; Kardeh Bahareh; Saki Mohammad Reza
Volume 20, Issue 3 , 2017, , Pages 79-83
Abstract
Background: Psoriasis is a chronic autoimmune skin disorder with relapsing erythematous scaling plaques and joint or nail involvement. A greater occurrence of other autoimmune diseases has been reported in these patients. Additionally, their family members are more likely to be diagnosed with psoriasis. ...
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Background: Psoriasis is a chronic autoimmune skin disorder with relapsing erythematous scaling plaques and joint or nail involvement. A greater occurrence of other autoimmune diseases has been reported in these patients. Additionally, their family members are more likely to be diagnosed with psoriasis. The aimof this study is to assess the prevalence of certain autoimmune diseases in first degree relatives of patients with psoriasis compared with a control group. Methods: In this cross-sectional study we used a questionnaire to compare the frequency of type 1 diabetes, autoimmune thyroid disease, vitiligo, lupus erythematosus, multiple sclerosis, ulcerative colitis, Crohn’s disease, and rheumatoid arthritis in first degree relatives of 109 pathologically confirmed psoriasiscases with the first degree relatives of 109 age-sex matched controls. R programming language (version 3.3.1 for Windows) and the rattle graphical user interface (GUI) package were applied for statistical analysis. A P-value?0.05 was considered to be statistically significant. Results: We compared 955 first degree relatives of psoriatic patients with 934 family members of the controls. There was significantly greater total autoimmune diseases [odds ratio (OR): 2.74, 95% confidence interval (CI): 1.95-3.87, P<0.001), particularly psoriasis (OR: 38.66, 95% CI: 5.3-282.19, P<.0001), in first degree relatives of psoriatic patients compared to family members of the control group. Regardless of gender, autoimmune thyroid disease was more prevalent among first degree relatives of psoriatic patients (OR: 2.81, 95% CI: 1.36-5.83, P=.0066). No statistically significant difference was found regarding type 1 diabetes, rheumatoid arthritis, multiple sclerosis, vitiligo, Crohn’s disease, and ulcerative colitis. Conclusion: First degree relatives of patients with psoriasis had significantly higher autoimmune diseases. This finding was particularly noticed for psoriasis and autoimmune thyroid disease.
Supreeti Biswas; Kanchan Kumar Mondal; Indranil Saha; Rathindra Nath Dutta; Saibendu Kumar Lahiri
Volume 13, Issue 2 , 2010, , Pages 37-41
Abstract
Introduction: Acne vulgaris is a frequently encountered skin disease in daily practice. Its clinico-epidemiological status was evaluated in this study.Methods: Four hundred patients were studied by record-based observation for 2 years in the Acne Clinic of a tertiary care hospital.Results: This study ...
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Introduction: Acne vulgaris is a frequently encountered skin disease in daily practice. Its clinico-epidemiological status was evaluated in this study.Methods: Four hundred patients were studied by record-based observation for 2 years in the Acne Clinic of a tertiary care hospital.Results: This study revealed a male preponderance (53%) with a higher prevalence in adolescents (75%). Women with a regular menstrual cycle had a lower acne grading (ρ = – 0.31). Increased physical activity led to a decrease in acne grading (ρ = – 0.20). An association was found between acne and family history (42%) and nonvegetarian, oily, spicy fast food (99%). Our prescribed allopathic treatment in the Acne Clinic showed improvement. No drug induced ocular toxicity was observed. Hot, humid, dusty environment influenced the majority (87%) of the respondents. Urbanization (69%) increased the occurrence of acne.Conclusion: Community based studies are required to find out the actual burden of acne vulgaris.
Azam Jah Samdani; Bahram Khan Khoso
Volume 12, Issue 2 , 2009, , Pages 42-46
Abstract
Background: Oculocutaneous albinism is a disease with an autosomal recessive inheritance pattern in most cases. People with Oculocutaneous albinism face many health, psychological and financial issues. In this study, we report a unique village of Bhatti tribe in Jacobabad District, Pakistan, in which ...
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Background: Oculocutaneous albinism is a disease with an autosomal recessive inheritance pattern in most cases. People with Oculocutaneous albinism face many health, psychological and financial issues. In this study, we report a unique village of Bhatti tribe in Jacobabad District, Pakistan, in which 40 children and adults with albinism live. The aim of this study was to observe the pattern of inheritance, complications and socioeconomic impacts of this condition on the community.Methods: Detailed clinical history and relevant data were recorded on a specially designed performa followed by clinical examination by a consultant dermatologist together with his team to observe the extent of the disease and associated complications in two seasons (winter and summer).Result: This village, with a total population of 810, had 40 cases, 17 male and 23 female, ranging in age from 6 months to 35 years. About 65% of the affected individuals were younger than 16 years of age. There were 22 involved families in this village and 2 of them had 3 or 4 affected members. In this area, which is geographically close to the equator, all 40 cases (100%) had photodermatosis and 36/40 cases (90%) had bacterial skin infections during summer. In addition, they had limited outdoor exposure during this season. These complications also caused occupational, social and educational limitations 9 months a year. Eye problems were present in all 40 cases; however, all 40 cases were malignancy free.Conclusion: Oculocutaneous albinism is challenging not only because of its management but also because of its social and financial impacts. The current trend of consanguineous marriages, prevalent in this village, puts further emphasis on the role and the importance of marriage counseling in such situations.
Mohammad Dehghan; Sepideh Hajian; Nazila Alborzi; Afsaneh Borgheyee; Amir Hussein Noohi
Volume 12, Issue 1 , 2009, , Pages 13-15
Abstract
Background: Dermatophytes are a group of closely related fungi that invade keratinized tissues (skin, hair and nails) of humans and animals and produce infections called dermatophytosis. Our objective was to determine causative agents of dermatophytosis in Gorgan, North of Iran. Methods: Data was based ...
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Background: Dermatophytes are a group of closely related fungi that invade keratinized tissues (skin, hair and nails) of humans and animals and produce infections called dermatophytosis. Our objective was to determine causative agents of dermatophytosis in Gorgan, North of Iran. Methods: Data was based on collecting specimens from 1108 patients clinically suspected to have fungal infection during five years from 2003 through 2007. Specimens were collected from hair, nail and skin and were investigated by direct examination and cultured in Sabouraud dextrose agar. Fungal colonies were identified by macroscopic and microscopic examination and supplementary tests. Results: 351 samples out of 1108 were positive for dermatophytes and 277 ones had positive cultures. Epidemophyton floccosum was the most frequent species (70.4%) followed by Trichophyton rubrum (14.5%) and Microsporum audouinii (7.2%). Regarding the location of the lesions, groin and nails were the most frequent sites that developed dermatophytosis in the majority of the patients. Conclusion: Dermatophytosis is probably still one of the most infectious diseases in Iran. The anthropophilic (E.fluoccosum) and zoophilic (T. rubrum) species were the most common causes of dermatophyte of tinea in Gorgan, north of Iran. The frequency of tinea was higher in females and tinea cruris showed a remarkably increasing rate and can be an important public health issue in Gorgan.
Farajzadeh Saideh; Esfandiarpour Iranj; Pourhamzadeh Bahareh
Volume 10, Issue 4 , 2007, , Pages 320-328
Abstract
زمینه و هدف: از آن جایی که بیماری های پوستی در دوران کودکی از جهت های زیادی با افراد بالغ متفاوت است لذا تعیین الگوی شیوع بیماری های کودکان نقش مهمی در تعیین راه کارهای ...
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زمینه و هدف: از آن جایی که بیماری های پوستی در دوران کودکی از جهت های زیادی با افراد بالغ متفاوت است لذا تعیین الگوی شیوع بیماری های کودکان نقش مهمی در تعیین راه کارهای درمانی و پژوهشی دارد. هدف از این مطالعه تعیین الگوی شیوع بیماری های پوستی اطفال در کودکان مراجعه کننده به کلینیک های تخصصی پوست شهر کرمان بود. روش اجرا: در این مطالعه که از نوع توصیفی- تحلیلی، مقطعی است 937 نفر از کودکان زیر 16 سالی که به کلینیک های تخصصی پوست شهر کرمان در فاصله شهریور تا اسفند 85 مراجعه کرده بودند وارد مطالعه شدند. برای هر یک از بیماران پرسش نامه شامل سن، جنس، محل زندگی، تحصیلات والدین و نوع بیماری پوستی تکمیل شد. بیماری های پوستی توسط متخصص و بر اساس علایم و معاینه بالینی و روش های پاراکلینیک شامل بیوپسی، اسمیر و کشت باکتریال، اسمیر قارچ، Woods lamp و Tzank test تشخیص داده شد. یافته ها: طبق نتایج به دست آمده در مجموع درماتیت ها و عفونت های پوستی شایع ترین بیماری ها را تشکیل می داد. در بین درماتیت ها، درماتیت آتوپیک و سبورئیک از بقیه شایع تر و درماتوز پلانتار جوانان و لیکن سیمپلکس مزمن از بقیه نادرتر بود. در بین عفونت ها هم، عفونت های ویروسی و انگلی شایع تر از انواع باکتریایی و قارچی بود. در مقایسه بین دخترها و پسرها خال های ملانوسیتی به طور معنی داری در دخترها بیش تر از پسرها بود (02/0>p). اختلال های کراتینیزاسیون در کودکان مادران تحصیل کرده کم تر مشاهده شد (006/0>p). نتیجه گیری: طبق نتایج به دست آمده، درماتیت آتوپیک شایع ترین بیماری در این مطالعه بود که علت آن ممکن است به دلیل تغییر رژیم غذایی، عوامل پری ناتال و افزایش تماس با آلرژن های محیطی باشد. بیماری شایع بعدی عفونت های پوستی بود که این مطلب نشانه اهمیت توجه به مسایل بهداشتی این گروه سنی است.
Mohammad Taghi Noorbala
Volume 10, Issue 1 , 2007, , Pages 13-19
Abstract
Background and aim: Skin cancer is the most common human cancer. Ultraviolet radiation is now recognized as the most important risk factor for skin cancer development. Light skin colored individuals that spend more time outdoors in day are more susceptible to disease. In this study skin cancer situation ...
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Background and aim: Skin cancer is the most common human cancer. Ultraviolet radiation is now recognized as the most important risk factor for skin cancer development. Light skin colored individuals that spend more time outdoors in day are more susceptible to disease. In this study skin cancer situation in Yazd (located in a hot, dry and desert area) was reviewed.Materials and methods: In this existing data study all recorded cancers in pathology laboratory of University of Medical Sciences of Yazd between 1988-1996 were reviewed and skin cancers were studied.Results: 2360 patients with cancer were recorded. Skin cancer was the most common with 646 cases (27.3%). Bladder, stomach, breast and esophagus cancers were the other most common cancers. Among skin cancers basal cell carcinoma was the most common (77%). Other skin cancers included squamous cell carcinoma (17.8%), malignant melanoma (2.8%) and miscellaneous tumors (2.4%). Skin cancers were 1.5 times more common in males, and the majority of patients were in seventh and eighth decades of life. 91.5% of skin cancers were on face, head and neck.Conclusion: Skin cancer was the most common human cancer in Yazd. Considering skin type and intensity of sun in this area, more intensive preventive programs must be implemented.
A Zamanian; MH Azimian
Volume 8, Issue 5 , 2005, , Pages 379-383
J Ayatollahi
Volume 8, Issue 5 , 2005, , Pages 384-387
Sh Sadr Eshkevari; A Maboudi; E Akbari Dastak; J Golchai; J Shams Guilani; A Dorjani; N Alizadeh; O Zargari
Volume 8, Issue 2 , 2005, , Pages 104-109
Abstract
Background: Pemphigus is a serious blistering disease with considerable mortality, which heavily burdens on health care system because of the long time hospitalization. It is rare in north America but is considered as the most common immunobullous disease in eastern countries such as Malaysia and China. ...
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Background: Pemphigus is a serious blistering disease with considerable mortality, which heavily burdens on health care system because of the long time hospitalization. It is rare in north America but is considered as the most common immunobullous disease in eastern countries such as Malaysia and China. Objective: The purpose of this study was to define the epidemiologic features of pemphigus in north of Iran. Patients and Methods: One-hundred and twenty-six cases of pemphigus diagnosed based on clinicohistological findings that were hospitalized in Rasht, in north of Iran, between 1995-2001 were studied. Epidemiological data collected from their hospital records were entered in SPSS software and statistical analyses were performed by T-test, Chi-square and Pearson correlation tests. Results: Pemphigus vulgaris was the most common type (83%), followed by foliaceous (6%) and vegetans (1%). The mean age of patients was 45.6 years, with 47.2 in vulgaris and 37.8 in foliaceous group (P<0.05). There was no sex difference in mean age in vulgaris group, whereas the mean age of foliaceous group was 30.2 for females and 51.8 years for males (P<0.05). Female:male ratio was 1.5:1, with 1.44:1 for vulgaris and 1.85:1 for foliaceous groups, respectively. The oral mucosa was the first site of involvement in 63% of vulgaris cases, and 72.4% of them had widespread mucocutaneous disease at the time of hospitalization. Frequency of illness in spring (32%) was higher than other seasons. The mean time for 80% improvement of lesions in hospital was significantly higher in cases with widespread mucocutaneous lesions than cases with only skin or mucosal illness (P<0.05). Conclusion: These findings clearly demonstrate the need for continuous training of involved health workers (Dermatologists, dentists, otolaryngologists, general physicians) for early diagnosis and referral of disease, which not only could decrease the morbidity and mortality, complications rates for patients but also hospitalization costs for patients and health care system.
R Yaghoobi; AA Aliari; N Emad Mostovfi; SM Latifi
Volume 8, Issue 1 , 2004, , Pages 24-31
Abstract
Background: The incidence of oral cancers is different worldwide. Objective: To evaluate the rate of oral cancers in Khouzestan Province. Patients and Methods: The data were collected from the pathologic reports of pathology laboratories all around the province, during the time period of 1992-2002. Results: ...
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Background: The incidence of oral cancers is different worldwide. Objective: To evaluate the rate of oral cancers in Khouzestan Province. Patients and Methods: The data were collected from the pathologic reports of pathology laboratories all around the province, during the time period of 1992-2002. Results: Among the total received specimens, 305 cases of oral cancers were detected. One hundred ninety-three cases (63.2%) were male and 112 cases (36.8%) were female. Male to female ratio was 1.7 and mean age was 55.04±16.60 years. Squamous cell carcinoma was the most common malignancy (75% of total), and then standed the nasopharyngeal carcinoma (10.8%) and lymphoma (7.5%). The most common sites were lower lip (29.2%), tongue (19%) and nasopharynx (15.7%). Conclusion: Regardless of some minor differences, most of our findings were similar to other previous studies.
N Alizadeh; Sh Sadr Ashkevary; J Golchai; A Maboodi; AA Falahati
Volume 7, Issue 4 , 2004, , Pages 255-260
Abstract
Background: In spite of prevention and control programs, dermatophyte infections have a high prevalence worldwide. Objective: To do a descriptive study of dermatophytosis in Guilan. Patients and Methods: 217 patients whom were visited in Razi Hospital in Rasht in 1381 were screened for dermatophytosis ...
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Background: In spite of prevention and control programs, dermatophyte infections have a high prevalence worldwide. Objective: To do a descriptive study of dermatophytosis in Guilan. Patients and Methods: 217 patients whom were visited in Razi Hospital in Rasht in 1381 were screened for dermatophytosis and if had suspicious lesions, direct smear with KOH and culture were done. Results: 93 patients had positive smear (KOH 10%) and culture for dermatophytes. 50 patients were women and 43 patients were men. The most common patterns of dermatophytosis were tinea cruris (47.2%), tinea pedis (14%), tinea capitis (12.9%), onychomycosis, tinea manum, and tinea facei. Trichophyton mentagrophytes was the most common causative agent of tinea cruris that occurred more significantly in hot seasons. Conclusion: Tinea cruris was the most common type of dermatophytosis in this study. High prevalence of tinea cruris specially in women in comparison to the previous studies, may be due to occupational activity (Agriculture) and clothing of women in north of Iran.
J Golchai; O Zargari; M Gholipour; M Karbasi
Volume 7, Issue 1 , 2003, , Pages 29-32
Abstract
Background: Scabies is a contagious skin disorder and one of the most common itching dermatoses in whole of the world. Epidemiologic survey of scabies periodically done in many countries is a reflection of general status of public health in the community. Objective: To determine the prevalence of the ...
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Background: Scabies is a contagious skin disorder and one of the most common itching dermatoses in whole of the world. Epidemiologic survey of scabies periodically done in many countries is a reflection of general status of public health in the community. Objective: To determine the prevalence of the scabies and its relationship with age, sex family size and place of residence. Patients & Methods: In this observational-cross sectional study on the students of primary schools in Somea-Sara in 2000-2001, 3656 students (On the basis of stratified random sampling) were selected and examined. The diagnosis of scabies was made on the basis of clinical criteria and the demographic data were recorded. Results: 50 out of 3656 students (1.36%) were suffered from scabies. The prevalence of scabies was 1.0% in urban schools and 1.61% in rural schools, 1% in male students and 1.7% in female students. The most common age group was 8-9 years and the mean of family size in patients was 6.1 and 6.2 in urban and rural areas, respectively. Conclusion: This study indicated that prevalence of scabies is higher in lower socio-economic state and larger family size.
A Zamanian; M Farshchian; H Nazeri
Volume 6, Issue 4 , 2003, , Pages 31-33
Abstract
Background: Tinea pedis is probably the most common form of dermatophytosis in developed countries and it is one of the public health problems in the most societies. Moreover, wearing shoes, sweating and maceration are its predisposing factors. Objective: To evaluate the prevalence and determination ...
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Background: Tinea pedis is probably the most common form of dermatophytosis in developed countries and it is one of the public health problems in the most societies. Moreover, wearing shoes, sweating and maceration are its predisposing factors. Objective: To evaluate the prevalence and determination of type of tinea pedis in the personnel of Hamedan Sina Hospital. Patients and Methods: In a descriptive cross-sectional study, 156 employees of Hamedan Sina Hospital were examined clinically and by fungal skin smears. Results: Ninety-three (59.6%) of patients were male and 63 (40.4%) were female. Seven patients (4.48%) suffered from tinea pedis and T.mentagrophytis (Interdigital) was the main cause of infection. Conclusion: The prevalence of tinea pedis in this study was 4.48%, which is lower than its prevalence in developed countries.
M Farshchian; A Zamanian; M Safakish
Volume 6, Issue 1 , 2002, , Pages 26-31
Abstract
Background: Lichen planus has various clinical and epidemiologic features in different countries. Objectives: To determine clinical and epidemiologic patterns of lichen planus in dermatology department of Hamadan Sina Hospital during a ten-year period. Patients and Methods: This retrospective descriptive ...
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Background: Lichen planus has various clinical and epidemiologic features in different countries. Objectives: To determine clinical and epidemiologic patterns of lichen planus in dermatology department of Hamadan Sina Hospital during a ten-year period. Patients and Methods: This retrospective descriptive study was performed on 363 patients (Including 190 females and 173 males) suffered from lichen planus, referred to Hamadan Sina Hospital, during the years 1991-2001. Data were obtained from patients’ files and were analyzed by EPI6 software. Results: Among 6610 patients who were biopsied, 363 cases (5.5%) were diagnosed as lichen planus. Isolated mucous membrane involvement was observed in 36 patients (9.9%) and 9 patients (2.5%) had both skin and mucous membrane lesions. 318 patients (87.6%) had only skin involvement. The most common site of involvement was face in 71 patients (12.7%). Actinic lichen planus was the most common clinical form of lichen planus, which was seen in 126 patients (36.4%). Conclusion: Among the patients suffering from lichen planus who were biopsied, the face was the most common site of involvement and lichen actinicus was the most common clinical pattern.
R Yaghoobi
Volume 3, Issue 1 , 1999, , Pages 16-23
Abstract
Background: Pemphigus is an autoimmune disease characterized with intra-epidermal cleavage. Objective: The aim of this study was to examine the clinical and epidemiologic features of pemphigus in Khouzestan province, southwest Iran. Patients and Methods: All new cases of pemphigus admitted in the department ...
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Background: Pemphigus is an autoimmune disease characterized with intra-epidermal cleavage. Objective: The aim of this study was to examine the clinical and epidemiologic features of pemphigus in Khouzestan province, southwest Iran. Patients and Methods: All new cases of pemphigus admitted in the department of dermatology, Sina Hospital, Ahwaz University from October 1990 to September 1999 were studied. The diagnosis of pemphigus was based on clinical and histological findings. Results: One hundred-eleven pemphigus patients represented 4.7% of 2358 patients admitted to this department in this period. The most common presentation was pemphigus vulgaris (81.98%), followed by pemphigus foliaceous (18.02%). Pemphigus was observed more common in women (62 of 111; 55.86%) than in men (49 of 111; 44.14%). The mean age of all variants of pemphigus and in both sex at the time of diagnosis was 42.5 years. The lag time between the onset of illness and final diagnosis in pemphigus vulgaris and pemphigus foliaceous were 4 and 9 months, respectively. In pemphigus vulgaris patients, the onset of lesions were 54.65% and 45.34% from mucous membranes (Mainly oral cavity) and skin in 54.65% and 45.35% of cases, respectively. In all of pemphigus foliaceous patients, the onset of lesions was from the skin. The mortality was 6.30%, more in pemphigus foliaceous than vulgaris. Conclusion: This study showed that pemphigus is relatively common in Khouzestan province, compared with other regions. Pemphigus vulgaris is the most common variant and mortality was higher in pemphigus foliaceous.