Nasim Niknezhad; Behnaz Hamedani; Abbas Zamanian; Reza Mahmoud Robati; Elnaz Hamedani
Abstract
Introduction: Acne vulgaris affects individuals of all ages, and isotretinoin is the most effective treatment available for this disease. However, serious adverse effects, including the possibility of depression and suicide, could limit its use. This study aimed to investigate the ...
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Introduction: Acne vulgaris affects individuals of all ages, and isotretinoin is the most effective treatment available for this disease. However, serious adverse effects, including the possibility of depression and suicide, could limit its use. This study aimed to investigate the frequency of depression in patients with acne vulgaris treated with oral isotretinoin.Materials and Methods: Forty acne vulgaris patients treated with oral isotretinoin and 40 age- and sex-matched controls treated with a systemic antibiotic (doxycycline 100-200 mg/day) and atopical retinoid were enrolled in this study. The depression score was measured based on Beck’s Depression Inventory (BDI) in both groups before and after two months of treatment.Result: The BDI score and the rate of depression were not significantly different between the two groups after the twomonth treatment period. Moreover, we did not find any significant change in BDI score in each group after treatment (P > 0.05).Conclusion: Our study showed that short-course oral isotretinoin therapy does not increase the depression rate among acne vulgaris patients. It should be noted that oral isotretinoin causesa significant clinical improvement in patients with moderate to severe acne vulgaris, which could be associated with a decrease in depression scores.
Ghazal Shariatpanahi; Rezvan Hashemi; Mahsa Asadabadi; Nava Shirzadi; Nazgol Sadat Haddadi; Safoura Shakoei
Abstract
Background: Acne is a common chronic inflammatory skin disease predominantly occurring during adolescence; this condition adversely affects a person’s self-esteem and can be associated with metabolic disorders. This study aimed to investigate the prevalence of metabolic syndrome and its components ...
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Background: Acne is a common chronic inflammatory skin disease predominantly occurring during adolescence; this condition adversely affects a person’s self-esteem and can be associated with metabolic disorders. This study aimed to investigate the prevalence of metabolic syndrome and its components in adolescent girls with acne compared to a control group. Materials and Methods: In this cross-sectional study,105 adolescent girls aged 12-18 years were assigned to either the acne (case; n=55) or control group (n=50). The case group was selected from the Dermatology Department of a general hospital in Tehran, Iran, between January and August 2017. Acne lesions were confirmed and graded by a dermatologist. Clinical and biochemical parameters were evaluated for all participants. Results: The prevalence of metabolic syndrome in patients with and without acne was 18.2% and 14%, respectively. As a result, metabolic syndrome was not correlated with acne in adolescent girls (P=0.561). In addition, the mean body mass index (P=0.89), waist circumference (P=0.62), mean systolic and diastolic blood pressures (P=0.57 and 0.62, respectively), fasting blood sugar (P=0.59), total cholesterol, and low-density lipoprotein cholesterol levels were comparable between the studied groups (P>0.05). Moreover, triglyceride levels were significantly lower in the acne group (P=0.028), whereas this group featured a higher level of high-density lipoprotein cholesterol (P=0.02). However, the logistic regression results showed that none of the measured lipids were associated with acne. Conclusion: The findings indicated that metabolic syndrome and its components (representing metabolic imbalance) were not correlated with acne in adolescent girls.
Balakrishna P Nikam; Mohan Kale; Varsha Jamale; Tunika Arora; Asma Hussain; Nishchhal Shrivastav
Abstract
Background: Self-inflicted acne excoriée is often observed in patients with compulsive skin picking, posing a challenge for diagnosis and treatment as the exact psychiatric cause remains unknown. Studies have suggested that serotonin reuptake inhibitors such as fluoxetine may help in the management ...
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Background: Self-inflicted acne excoriée is often observed in patients with compulsive skin picking, posing a challenge for diagnosis and treatment as the exact psychiatric cause remains unknown. Studies have suggested that serotonin reuptake inhibitors such as fluoxetine may help in the management of this condition. To determine the efficacy and safety profile of fluoxetine in the treatment of acne excoriée and to study the psychological profiles of patients. Methods: Sixty patients of either sex aged ≥16 years with acne excoriée were assigned to either Group A (n=30), which received oral fluoxetine (F) (20 mg/day) and oral doxycycline (D) (100 mg/day) with topical clindamycin (1%), or Group B (n=30), which received a placebo (P), oral doxycycline (100 mg/day), and topical clindamycin (1%). Patients were evaluated for standardized rating scales and followed up every two weeks for 12 weeks. Results: Female gender predominance was observed in both groups, with most patients exhibiting anxiety and depression. With each follow-up visit (2nd, 3rd, 4th, and 5th) in both groups (A and B), the mean AESI (91.4% vs. 26.7%), HAM-A (80% vs. 27.7%), MADRS (68.1% vs. 28.2%), YBOCS (98.27% vs. 15.63%), PGA (88.47% vs. 31.38%), and VAS (99.17% vs. 37.67%) scores decreased from baseline by the final visit, indicating improved patient conditions. Significant differences were observed between the two groups (p <0.001) in the overall response, indicating that fluoxetine was more efficacious than the control. No remarkable side effects were noted. Conclusion: Fluoxetine efficiently managed acne excoriée without remarkable side effects. Background: Self-inflicted acne excoriée is often observed in patients with compulsive skin picking, posing a challenge for diagnosis and treatment as the exact psychiatric cause remains unknown. Studies have suggested that serotonin reuptake inhibitors such as fluoxetine may help in the management of this condition. To determine the efficacy and safety profile of fluoxetine in the treatment of acne excoriée and to study the psychological profiles of patients. Methods: Sixty patients of either sex aged ≥16 years with acne excoriée were assigned to either Group A (n=30), which received oral fluoxetine (F) (20 mg/day) and oral doxycycline (D) (100 mg/day) with topical clindamycin (1%), or Group B (n=30), which received a placebo (P), oral doxycycline (100 mg/day), and topical clindamycin (1%). Patients were evaluated for standardized rating scales and followed up every two weeks for 12 weeks. Results: Female gender predominance was observed in both groups, with most patients exhibiting anxiety and depression. With each follow-up visit (2nd, 3rd, 4th, and 5th) in both groups (A and B), the mean AESI (91.4% vs. 26.7%), HAM-A (80% vs. 27.7%), MADRS (68.1% vs. 28.2%), YBOCS (98.27% vs. 15.63%), PGA (88.47% vs. 31.38%), and VAS (99.17% vs. 37.67%) scores decreased from baseline by the final visit, indicating improved patient conditions. Significant differences were observed between the two groups (p <0.001) in the overall response, indicating that fluoxetine was more efficacious than the control. No remarkable side effects were noted. Conclusion: Fluoxetine efficiently managed acne excoriée without remarkable side effects. Keywords: acnevulgaris,fluoxetine, doxycycline
Safoura Shakoei; Nazanin Nasri; Ghazal Shariatpanahi; Rezvan Hashemi
Abstract
Background: Acne is a chronic inflammatory skin disease and a cosmetic problem with considerable emotional and psychological side effects and symptoms, such as pain and pruritus. Some controversies exist concerning the involvement of dietary factors, including glycemic load (GL), ...
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Background: Acne is a chronic inflammatory skin disease and a cosmetic problem with considerable emotional and psychological side effects and symptoms, such as pain and pruritus. Some controversies exist concerning the involvement of dietary factors, including glycemic load (GL), in the pathogenesis of acne. Accordingly, we aimed to determine the role of GL and anthropometric measures in acne development among girls aged 12-18 years in Tehran, Iran.Methods: In this cross-sectional study, 99 girls (45 girls without acne and 54 girls with acne) aged 12 18 years completed a threeday food record. Anthropometric measures, such as height, weight, waist circumference, and body mass index (BMI), were also assessed. Additionally, an expert dermatologist scored the severity of acne, and then, anthropometric measures and GL were examined in the groups.Results: The results showed no significant difference in dietary GL, height, weight, BMI, and waist circumference between the groups. Furthermore, the severity of acne was not significantly associated with GL.Conclusion: The present results did not confirm the association between acne and dietary carbohydrates, including GL. However, further research can contribute to determination of the effect of diet on acne and its severity.
Azadeh Goodarzi; Elham Behrangi; Mohammadreza Ghassemi; Golnaz Mehran; Niloofar Teymoori; Amir Pouyan Ghahremani; Maryam Biglari Abhari
Abstract
Background: Acne vulgaris is among common bothersome skin problems. Recognition of contributing factors would help to prevent acne. Some dietary and inflammatory factors are among suggested etiologies. Accordingly, in this study, the serum levels of calcium, vitamin D, phosphorous ...
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Background: Acne vulgaris is among common bothersome skin problems. Recognition of contributing factors would help to prevent acne. Some dietary and inflammatory factors are among suggested etiologies. Accordingly, in this study, the serum levels of calcium, vitamin D, phosphorous and C-reactive protein (CRP) were determined and compared in acne patients and healthy subjects. Methods: In this case-control study, 144 consecutive subjects with and without acne (moderate-very severe) referred to Rasoul Akram Hospital in 2016 were enrolled. In this regard, the serumcalcium, phosphorous, CRP, vitamin D were determined in the subjects and compared between the groups. Results: The results indicated that serum CRP, calcium, and phosphorous level were alike between the groups (P > 0.05) without any relation to acne severity except CRP. The serum vitamin D level was significantly different (P = 0.0001), but it was not associated with acne severity. Serum calcium levels of males were significantly higher in both groups. Conclusions: Based on our results, it may be concluded that calcium, phosphorous, and CRP levels are not associated with acne incidence, but the serum vitamin D is related to acne presentation. CRP levels were positively associated with acne vulgaris severity.
Azadeh Goodarzi; Masoumeh Roohaninasab; Najmol Sadat Atefi; Afsaneh Sadeghzadeh Bazargan; Mohammadreza Ghassemi; Amir Pouyan Ghahremani; Niloofar Teymoori; Maryam Biglari Abhari
Abstract
Background: Acne vulgaris is a dermatologic disorder with a wide variety of distribution and presentation. Its high prevalence and important cosmetic and psychological concerns focusing on contributing factors would be of great value for better approach and prevention of acne vulgaris. ...
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Background: Acne vulgaris is a dermatologic disorder with a wide variety of distribution and presentation. Its high prevalence and important cosmetic and psychological concerns focusing on contributing factors would be of great value for better approach and prevention of acne vulgaris. There are many articles that argue the role of some dietary and inflammatory factors in acnevulgaris. In this study, the serum levels of zinc in acne patients were determined and compared with healthy subjects. Methods: In this age and gender matched case-control study, 200 consecutive subjects with and without acne (moderate-very severe) referring to Rasoul Akram Hospital, 2016, were enrolled,and their serum zinc levels were determined and compared across the groups. Results: Serum zinc levels were alike across the groups (P > 0.05), and the severity of acne was not related to zinc level. The levels of zinc were significantly different between genders in the casegroup (men had lower levels). In female patients with acne, the level of zinc was inversely correlated with acne severity. Conclusion: Zinc is not related to acne incidence or its grade, but men with acne have lower levels of zinc compared with women. Also, acne severity in women is inversely correlated with zinc level. It can be assumed that zinc supplementation may be a good trend in men with acne or alleviate the severity of acne in women, which needs more evaluation and work up.
Azadeh Goodarzi; Masoumeh Roohaninasab; Elham Behrangi; Mohammadreza Ghassemi; Amir Pouyan Ghahremani; Niloofar Teymoori
Abstract
Skin as an outer layer of body and a main connection between the body and the environment is a way that pathogens can access the body; Therefore, it has a crucial protecting role for the body because of obstacle functioning and micobiota. Factors that seem to commonly contribute to ...
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Skin as an outer layer of body and a main connection between the body and the environment is a way that pathogens can access the body; Therefore, it has a crucial protecting role for the body because of obstacle functioning and micobiota. Factors that seem to commonly contribute to the disease are follicular hyperkeratinization, propionibacterium acnes, sebum production, and inflammation; however, pathogenesis of acne vulgaris as an inflammatory skin disorder is still poorly understood. Google Scholar and PubMed databases were searched for all related articles, using the key words of zinc, diet, vitamin D, BMI, and acne vulgaris.
Azadeh Goodarzi
Abstract
There are many patients with inflammatory acne vulgaris who are not compliant or eligible to consume acne medications, such as oral antibiotics or isotretinoin. PubMed and Medline databases were searched for all related articles. All finding were summarized and chronologically presented ...
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There are many patients with inflammatory acne vulgaris who are not compliant or eligible to consume acne medications, such as oral antibiotics or isotretinoin. PubMed and Medline databases were searched for all related articles. All finding were summarized and chronologically presented in the tables. Nonmedical device-based therapies largely improve the treatment of active inflammatory acne vulgaris, especially in patients who are not compliant or eligible to consume acne medications, do not respond to these drugs over a specified period of time, or do not sustain in the remission phase.
Behrangi Elham; Sadeghi Somayeh; Sadeghzadeh-Bazargan Afsaneh; Goodarzi Azadeh; Ghassemi Mohammadreza; Sepasgozar Saba; Rohaninasab Masoomeh
Abstract
Background: Insulin resistance and increased insulin-like growth factor (IGF)-1 with consequent mammalian target of rapamycin complex (mTORC) 1 overexpression is responsible for acne pathogenesis, especially in women with polycystic ovary syndrome (PCOS). Metformin is shown to improve acne as an adjunct ...
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Background: Insulin resistance and increased insulin-like growth factor (IGF)-1 with consequent mammalian target of rapamycin complex (mTORC) 1 overexpression is responsible for acne pathogenesis, especially in women with polycystic ovary syndrome (PCOS). Metformin is shown to improve acne as an adjunct therapy in females with PCOS and males with altered metabolic profile. We evaluated the use of metformin in the treatment of resistant and late-onset acne in females, and compared it with isotretinoin.
Methods: Females with late-onset acne or acne resistant to common therapies (n=70) were randomized to receive metformin (n=35) or isotretinoin (n=35) for 6 months. Changes in acne severity were scored by global acne grading system (GAGS) which was the primary outcome. Other endpoints were changes in the components of metabolic profile.
Results: Six-month treatment with metformin and isotretinoin significantly reduced the GAGS from 31.9 to 24.6 and from 34.1 to 13.3, respectively, indicating the superior impact of isotretinoin. Metfromin was more effective in decreasing the GAGS score in those with PCOS (13.5±7.1 vs. 24.2±19.4, P<0.05). Furthermore, patients with hirsutism had a higher reduction score with metformin compared to patients without hirsutism (21.1±9.1 vs. 30.2±6.4) (P<0.05). Lipid profile and fasting blood sugar were improved following the 6-month treatment with metformin, and isotretinoin increased the levels of liver enzymes and bilirubin (P<0.05).
Conclusion: Metformin is effective in treating late-onset or resistant acne and improving metabolic status, without serious side effects. In patients with altered metabolic profiles such as PCOS, metformin seems to be superior to isotretinoin regarding acne treatment.
Sepaskhah Mozhdeh; Mohammadi Ali; Nabavizadeh Sara Sadat; Faridi Pouya; Babaei Amir Hossein
Abstract
Background: Acne vulgaris is a multi-factorial disease affecting many aspects of life. This study was conducted to compare the efficacy of fenugreek seed extract and oral azithromycin in the treatment of acne vulgaris. Methods: A total of 20 patients with acne vulgaris aged between 12 and 30 years old ...
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Background: Acne vulgaris is a multi-factorial disease affecting many aspects of life. This study was conducted to compare the efficacy of fenugreek seed extract and oral azithromycin in the treatment of acne vulgaris. Methods: A total of 20 patients with acne vulgaris aged between 12 and 30 years old were entered into this 60-day, randomized, placebo-controlled, triple-blind study. The patients were randomly divided into two groups, (permuted block randomization, block size of 4), namely fenugreek and azithromycin groups. All the participants daily received two capsules containing 500 mg hydroalcoholic extract of fenugreek seeds or 125mg azithromycin, for two months. The patients were evaluated after 30 and 60 days from the start of the trial. The participants, investigators (the dermatologists who evaluated clinical responses), and statisticians who analyzed the data were blind for identity and allocation of the treatments. Results: The baseline GAGS scores in azithromycin and fenugreek groups were respectively equal to 19.66 and 23.12, and there was a reduction in both azithromycin (GAGS2=14.33) (P-value=0.019) and fenugreek extract group (GAGS2=22.75) (P-value=0.780) during the experiment. There was a statistically significant difference among the two groups (F= (2, 24) = 3.861, P=0.035). Conclusion: The effect of azithromycin was higher than fenugreek in the treatment of acne vulgaris.
Edalatkhah Hassan; Matin Elmira; Ahari Saeid Sadeghieh
Volume 20, Issue 2 , 2017, , Pages 54-58
Abstract
Background: Acne vulgaris has a multifactorial pathogenesis; however, the exact role of genetic predisposition is not clear. Some studies have reported an association between familiy historyof acne and moderate to severe acne. In this study, we investigated the relationship between familiy history and ...
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Background: Acne vulgaris has a multifactorial pathogenesis; however, the exact role of genetic predisposition is not clear. Some studies have reported an association between familiy historyof acne and moderate to severe acne. In this study, we investigated the relationship between familiy history and prevalence of acne vulgaris in girls 8 to 13 years of age.Methods: This case-control study enrolled 400 students. The participants were divided into two groups, case and control, with 200 students per group. The case group consisted of students with acne vulgaris and the control group included those without acne. The severity of acne was determined based on the Global AcneGrading Score (GAGS). The presence of acne in close relatives (father, mother, sister, brother) was determined through face to face interviews with participants’ mothers and phone contacts with other family members. All collected data were analyzed by SPSS software.Results: The case participants had a mean age of 10.62±1.71 years and those in the control group had a mean age of 10.54±1.70 years, which was not statistically significant. The mothers with acne vulgaris had the highest odds ratio (OR: 2.719, 95% CI: 1.788-4.133) between the case and the control groups. The ratio of encountering the probability with both parents developing acne vulgaris between the two groups was 2.346 (95% CI: 1.571-3.503).Conclusion: This study revealed a significant relationship between positive familial history of acne and prevalence of acne vulgaris.
Jawade Sugat A.; Saigaonkar Vaidehi A.; Kondalkar Ambika R.
Volume 19, Issue 4 , 2016, , Pages 105-112
Abstract
Background: Topical retinoid based combinations are recommended to enhance the outcome of acne treatment. Adapalene-benzoyl peroxide (BPO) combination gel was approved in 2009 for acne treatment. The aim of this study was to evaluate the efficacy and tolerability of adapalene 0.1%-benzoyl peroxide 2.5% ...
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Background: Topical retinoid based combinations are recommended to enhance the outcome of acne treatment. Adapalene-benzoyl peroxide (BPO) combination gel was approved in 2009 for acne treatment. The aim of this study was to evaluate the efficacy and tolerability of adapalene 0.1%-benzoyl peroxide 2.5% combination gel compared to adapalene 0.1% gel monotherapy and benzoyl peroxide 2.5% gel monotherapy in treatment of acne vulgaris in Indian patients.Methods: A randomized, parallel group, investigator-blind clinical trial was conducted from September 2014 to September 2015 in the Dermatology outpatient department. The patients were randomized into three groups of adapalene 0.1% gel, benzoyl peroxide 2.5% gel, and adapalene 0.1%-benzoyl peroxide 2.5% combination gel. The patients were asked to apply the allocated gel to the face in the evening for 12 weeks. Efficacy was evaluated using percent of reduction in total, inflammatory, and non-inflammatory lesions and success rate while tolerability was assessed by evaluating skin dryness, erythema, stinging or burning sensation and scaling at baseline and 1, 2, 4, 8, and 12 weeks.Results: At the end of 12 weeks, the success rate reached 37.2% with adapalene-BPO combination gel compared to 23.3% and 19.4% for adapalene and benzoyl peroxide gel monotherapy respectively. Adapalene-BPO combination gel was significantly effective in the reduction of total, non-inflammatory and inflammatory lesions by 75.9%, 75.4%, and 74.7% respectively compared to the corresponding monotherapies. Side effects with adapalene–BPO combination gel were mild and transient.Conclusion: Adapalene–BPO combination gel was more efficacious and better tolerated than adapalene and benzoyl peroxide gel monotherapy.
Hamideh Moravvej; Akbar Mousazadeh Halim; Maryam Yousefi; Soudabeh Givrad
Volume 15, Issue 1 , 2012, , Pages 7-10
Abstract
Background: Acne vulgaris is the most common disorder of pilosebaceous unit. Systemic antibiotics are known to be effective in its treatment. We performed this investigation to compare the efficacy of azithromycin with doxycycline in the treatment of acne vulgaris. Method: A twelve-week study was performed ...
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Background: Acne vulgaris is the most common disorder of pilosebaceous unit. Systemic antibiotics are known to be effective in its treatment. We performed this investigation to compare the efficacy of azithromycin with doxycycline in the treatment of acne vulgaris. Method: A twelve-week study was performed on 69 patients with moderate facial acne to compare the efficacy of oral azithromycin with oral doxycycline. Sixty patients completed the study. Patients in the treatment arm one were scheduled to receive 500 mg azithromycin once daily three times a week, and patients in the treatment arm two were instructed to use 100 mg doxycycline daily. All patients administered topical tretinoin cream every other night. Clinical assessment was made at baseline and then every 4 weeks. Result: There were statistically significant improvements in comedones and inflammatory lesion counts in both groups. Neither drug was shown to be more effective than the other. Conclusion: This study indicated that azithromycin had similar efficacy to doxycycline in reducing acne lesions.
Shizarpour Mohammad; Firooz Alireza; Pazooki Hamidreza; Khiabanloo Samad Rezai
Volume 11, Issue 2 , 2008, , Pages 67-72
Abstract
Background: Acne vulgaris is the most common cause for dermatology visits and is one of the most common diseases that people experience during their lives. Although this disease is not life-threatening, it may affect the life quality of the patients because of developing irreparable complications on ...
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Background: Acne vulgaris is the most common cause for dermatology visits and is one of the most common diseases that people experience during their lives. Although this disease is not life-threatening, it may affect the life quality of the patients because of developing irreparable complications on the skin. Dermatologists are in agreement about topical treatment in the mild to moderate acne vulgaris, but extensive using of tropical antibiotics and drug resistance have decreased their therapeutic benefits. In this study, we tried to compare the therapeutic effects of tropical azithromycin and clindamycin. Methods: This study was designed and performed as a double blind, randomized clinical trial. Thirty two patients with mild to moderate acne were treated with azithromycin and 30 patients, who were matched with the former group based on age, sex and severity of the disease, were treated with clindamycin for 12 weeks and results of their treatment were compared with each other. Results: results of this study showed that ratio of response to treatment and decreasing the grade of the disease and number of nodules, papules and pustules were not significantly different in the first month of the treatment in both groups while just the number of nodules in the group on azithromycin showed more decrease in the last months of treatment in comparison with clindamycin (0.88±0.75 vs. 0.25±0.75, p=0.015). Also, clindamycin had more side effects, but the rate of satisfaction with both drugs were high and showed no difference. In this study, no significant association was found between sex and response to treatment and evaluation of association between age and response to treatment showed a significant reverse association between age and decreasing the number of pustules (p=0.002 , r= - 0.492). Conclusion: sum of findings in this study show that topical azithromycin is an effective antibiotic with acceptable side effects and high degree of satisfaction in patients and it can be used for the treatment of mild forms of acne.
MJ Nazemi; AH Ehsani; M Ghiasi; R Mahmooud Robati; F Gouran
Volume 9, Issue 2 , 2006, , Pages 122-126
Abstract
Background and aim: Acne vulgaris is a chronic disease of pilosebaceous units which most commonly affects younger people. There are many different treatment modalities; each affects some mechanisms of acne pathogenesis. Systemic antibiotics are one of the most popular methods of treatment. In this study ...
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Background and aim: Acne vulgaris is a chronic disease of pilosebaceous units which most commonly affects younger people. There are many different treatment modalities; each affects some mechanisms of acne pathogenesis. Systemic antibiotics are one of the most popular methods of treatment. In this study the efficacy of oral erythromycin was compared with doxycyclin in the treatment of moderate to severe acne vulgaris.Materials and Methods: This study was planned and conducted as a double-blind clinical trial. Sixty eight patients with acne were divided into two groups. One group was treated with oral erythromycin with a dose of 1g/day and the other group received oral doxycyclin at a dose of 100 mg/day for 4 months. The clinical improvement was evaluated based on reduction in the number of lesions in each monthly visit. Adverse events were also recorded.Results: Both groups showed considerable improvement in the lesions of face and trunk wih no significant difference. There was also no significant difference between improvement in facial and truncal lesions in the patients treated with erythromycin but facial lesions significantly improved more than trucal ones in patients on doxycyclin.Conclusion: The efficacy of oral erythromycin and doxycyclin was not significantly different in the treatment of acne vulgaris and each of them can be used according to the clinical status of the patients.
H Seirafi; M Nakhjavani; F Farnaghi; AH Ehsani; P Hashemi; M Ghiasi; A Moosavi
Volume 9, Issue 2 , 2006, , Pages 150-153
Abstract
Background and aim: Acne is a chronic inflammatory disease of the pilosebaceous units. Its etiology is unknown. However, several studies have shown that some endocrinologic factors are involved in acne pathogenesis. The aim of this study was to assess some endocrionlogic indices in male patients with ...
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Background and aim: Acne is a chronic inflammatory disease of the pilosebaceous units. Its etiology is unknown. However, several studies have shown that some endocrinologic factors are involved in acne pathogenesis. The aim of this study was to assess some endocrionlogic indices in male patients with acne vulgaris and comparing them with normal controls.Materials and Methods: In this case-control study, 40 male patients with acne referred to Razi hospital during the first 9 months of 1382, and 20 age-matched healthy subjects were selected. Plasma level of insulin, fasting blood sugar (FBS), free testosterone and sex hormone binding globulin (SHBG) were determined and compared between the groups.Results: The mean FBS level was 89.8±13.3 mg/dl in patients with acne and 91.1±16.3 in controls (P=0.017). The mean free testosterone level in cases and controls were 24.8±12.01 and 21.4±10.8 nmol/L, respectively (P=0.029).Conclusion: In this study, the testosterone level in patients with acne was higher and the FBS level was lower than controls. It is recommended that these indices be taken into consideration in male patients with acne.
F Ghalamkar Pour; H Morravej Farshi; S Zolghadr
Volume 8, Issue 6 , 2006, , Pages 448-456
Abstract
Background and aim: Side effects of long-term systemic isotretinion use with high accumulative doses on skeletal system have been known, but there are few studies about the effects of short term isotretinoin therapy for acne patients. This study was aimed to recognize the effects of systemic isotretinion ...
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Background and aim: Side effects of long-term systemic isotretinion use with high accumulative doses on skeletal system have been known, but there are few studies about the effects of short term isotretinoin therapy for acne patients. This study was aimed to recognize the effects of systemic isotretinion on calcium homeostasis and bone density in acne patients referring to clinics affiliated to the Skin Research Center of Shahid Beheshti University of Medical Sciences.Materials and Methods: In this before and after clinical trial, 20 patients with severe acne vulgaris in whom systemic treatment with isotretinoin was indicated were assessed. They included 13 female and 7 male patients with a mean age of 24.3±4.7 years. Serum levels of calcium, phosphorus and alkaline phosphatase as well as lumbar and hip bone mineral density (BMD) of the patients were evaluted before and after treatment with 120 mg/kg total dose of isotretinion. Results were analysed using Wilcoxon signed ranked test before and after treatment and P values less than 0.05 were considered statistically significant.Results: The mean levels of serum calcium and alkaline phosphatase were decreased after treatment course while the mean level of serum phosphorus was increased in comparison to their mean levels before the treatment but the changes were statistically non-significant. BMD of neck and total femur showed no significant difference, but trivial increase (0.0151 gr/cm2) was detected in lumbar BMD after treatment (P<0.05).Conclusion: Considering no significant change in neck and total femur BMD and trivial and clinically unimportant increase in lumbar BMD (L<sub>2</sub>-L<sub>4</sub>), it seems that 120 mg/kg total dose of isotretinion that is used for acne has no significant effect on skeletal system.
MJ Nazemi Tabrizi; AH Ehsani; Y Sedaghat; P Noormohammad Pour; M Mohajer; P Saheb Nazar
Volume 8, Issue 1 , 2004, , Pages 15-18
Abstract
Background: Acne vulgaris is a chronic inflammatory disease of pilosebaceous unit. The role of Pityrosporum ovale (P.ovale) in the exacerbation of acne is still under debate. Objective: To determine the efficacy of topical 2% ketoconazole cream in comparison to placebo in the treatment of acne vulgaris ...
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Background: Acne vulgaris is a chronic inflammatory disease of pilosebaceous unit. The role of Pityrosporum ovale (P.ovale) in the exacerbation of acne is still under debate. Objective: To determine the efficacy of topical 2% ketoconazole cream in comparison to placebo in the treatment of acne vulgaris in patients with positive smear for P.ovale. Patients and Methods: A smear was obtained from lesions of 84 patients with acne vulgaris referred to Razi Hospital, Tehran. After determination of clinical and mycological grading, patients with positive smear for P.ovale were randomly treated with topical 2% ketoconazole cream or placebo. After 4 weeks the patients were evaluated for the clinical and mycological grading and treated with traditional anti-acne drugs. Results: Fifty-six of 84 patients had positive smears, 29 of them were treated with ketoconazole cream and 27 patients received placebo. Clinical grading before treatment was 2.60 and 2.21 in ketoconazole and placebo groups, which was reduced to 2.16 and 2.05, respectively. Mycological grading reduced from 1.4 to 0.44 in ketoconazole group, but did not change in placebo group (1.42). Conclusion: 2% ketoconazole cream was more effective than placebo in reduction of mycological grading but did not have any effect on clinical grading of acne.
M Heydari Seradj; N Naderi; E Naderi; M Seyf Naraghi
Volume 4, Issue 3 , 2001, , Pages 30-37
Abstract
Background: Studies investigating the possible role of personality and emotional factors in acne vulgaris patients have yielded inconsistent and sometimes contradictory results. Objective: The purpose of this study was to assess personality and psychological functioning in women with acne vulgaris and ...
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Background: Studies investigating the possible role of personality and emotional factors in acne vulgaris patients have yielded inconsistent and sometimes contradictory results. Objective: The purpose of this study was to assess personality and psychological functioning in women with acne vulgaris and compare them with normal women. Patients and Methods: Forty-seven consecutive female patients aged 15-30 years with acne vulgaris attending a clinic in west of Tehran during January and February 2000 were assessed using the Mini-Mult test, a shortened version of Minnesota Multiphasic Personality Inventory (MMPI). The results were analyzed using student’s t test. Results: The mean hypochondriasis scale score was greater in the study group in comparison to normal women (P<0.02). The mean depression and psychoasthenia scale scores were greater in patients younger than 22 years in comparison to those 22 years or older (Respectively, P<0.05 and P<0.005). The mean paranoia scale score was smaller in those patients who were treated for acne vulgaris 3 or more times in the past in comparison to those who were treated less than 3 times (P<0.05). Conclusion: Women aged 15-30 years with acne vulgaris used the disease as a tool to attract others attention. Anxiety and depressin were more common in female patients younger than 22 years. Those patients who were treated for acne vulgaris 3 or more times in the past were tough-minded persons who refused to accept others recommendations.
MR Mortazavi
Volume 2, Issue 4 , 1999, , Pages 31-34
Abstract
The inefficiency of current therapies of acne vulgaris, side effects and teratogenicity of topical and oral retinoids resulted in the need to find out new drugs. Adapalene 0.1% gel or solution with retinoid properties is effective in treatment of acne, and improves both inflammatory and non-inflammatory ...
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The inefficiency of current therapies of acne vulgaris, side effects and teratogenicity of topical and oral retinoids resulted in the need to find out new drugs. Adapalene 0.1% gel or solution with retinoid properties is effective in treatment of acne, and improves both inflammatory and non-inflammatory lesions. The anti-inflammatory properties of adapalene and its specific tendency to bind to retinoic acid receptors (RAR) are characteristic. Different multicenter clinical trials have demonstrated that topical adapalene is much better tolerated and at least as effective in the treatment of acne as the topical tretinoin 0.025% gel. In conclusion the equal efficacy and superior tolerability of adapalene compared to tretinoin, and also its unique anti-inflammatory effects, made this new agent a major advance in topical therapy of acne.