Razieh Bokaiean; Mahnoush Momeni; Parisa Sabrjoo; Mostafa Dahmardehei; Maryam Roham; Hossein Rahber
Abstract
Background: Active Leptospermum honey has non-peroxide antibacterial and anti-inflammatory effects, rendering it suitable for wound healing. Leptospermum honey is endemic in New Zealand belonging to the manuka bush (Leptospermum scoparium). The objective of the present research was to compare the efficacy ...
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Background: Active Leptospermum honey has non-peroxide antibacterial and anti-inflammatory effects, rendering it suitable for wound healing. Leptospermum honey is endemic in New Zealand belonging to the manuka bush (Leptospermum scoparium). The objective of the present research was to compare the efficacy of manuka honey dressing with conventional dressing regarding skin graft donor sites following a burn injury.Methods: This study was carried out in the department of surgery, Iran University of Medical Sciences, Tehran, Iran. It is a noncontrolled prospective trial, and an open-label study, analyzing Leptospermum honey and conventional dressing for the treatment of donor site areas for skin grafts. Data were collected from 15 eligible patients with burn wound. Two independent donor sites were formed, one of which was treated with active Leptospermum honey dressing and the other covered through the conventional method. Further collected was information regarding subjects’ demographics, self-reported pain (VAS scale), wound surface areas and bacterial wound culture.Results: In the treatment of skin graft donor sites, honey proved to be less painful compared with the conventional group (P=0.001). Three and seven days following treatment, a significant decrease was observed in the mean wound surface areas in the honey group (P=0.001). There was no significant difference between honey and conventional dressings with regards to the rate of infection (20% in honey dressing versus 40% in conventional group; P=0.068).Conclusions: Active Leptospermum honey dressing accelerates the healing process, decreases pain and has antimicrobial activity and can be used for care of skin graft donor sites.
Mohamed Oulad Saiad; Hamza Hokoumi; Mohamed el Bouaychi; Noureddine Rada; Ghizlane Draiss; Mohamed Bouskraoui
Abstract
For more than 25 years, honey has been employed to facilitate the healing of complex wounds with excellent results. Here, we report the case of a two-and-a-half-year-old agammaglobulinemia patient admitted in our unit for severe sepsis with extensive skin necrosis in the groin, penis and scrotum. An ...
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For more than 25 years, honey has been employed to facilitate the healing of complex wounds with excellent results. Here, we report the case of a two-and-a-half-year-old agammaglobulinemia patient admitted in our unit for severe sepsis with extensive skin necrosis in the groin, penis and scrotum. An Ecthyma Gangrenosum was corroborated by the isolation of Pseudomonas aeruginosa in wound swab culture. The child was treated by broad-spectrum antibiotics. Following resuscitation, the prognosis of external genitalia remained reserved. An extended necrosectomy was performed on the groin, leaving a large and deep wound. No improvement occurred with standard local therapy; moreover, the striking particularity of the present immunosuppressed case was that necrosis extended and engaged the genitalia. Such condition left us with no alternative except to try honey dressings without much conviction, which, surprisingly, resulted in an improvement in the wound, until total healing was achieved. Honey seems to be the local treatment of choice for ecthyma gangrenosum.
MA Nilforoush Zadeh; Sh Moradi; R Derakhshan; E Haft Baradaran; F Jafari
Volume 9, Issue 3 , 2006, , Pages 221-226
Abstract
Background and aim: Cutaneous leishmaniasis (CL) is an edemic disease widely spread in Iran. Although several treatments have been tried, none has been found as simple and effective. Honey has been used in the treatment of chronic ulcers and its anti-leishmanial effects have also been reported. So we ...
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Background and aim: Cutaneous leishmaniasis (CL) is an edemic disease widely spread in Iran. Although several treatments have been tried, none has been found as simple and effective. Honey has been used in the treatment of chronic ulcers and its anti-leishmanial effects have also been reported. So we assessed the efficacy of honey in acute CL.Materials and Methods: In a randomized clinical trial, 100 patients with CL referred to Skin and Leishmaniasis Research Center were treated with either weekly intra-lesional injection of Glucantime alone or combined with twice daily topical application of honey. The patients were evaluated clinically 2 ,3 and 4 months after treatment.Results: Ninety patients completed the study, forty-five patients were treated in each group. At the end of trial, 32 patients (71/1%) of these treated with Glucantime alone and 23 patients (51/1%) treated with honey were cured (P=0.04).Conclusion: Drug interference and inhibition of bioavailability of Glucantime by honey may decrease the efficacy of Glucantime in treatment of CL.
M Bayat
Volume 3, Issue 2 , 2000, , Pages 23-26
Abstract
Introduction: Positive effects of topical application of honey on open skin wounds have been observed, Mast cell are playing role in normal wound healing and its disturbances but the role of mast cells in wound healing in existence of honey is uncertain. Objective: The aim of this investigation was to ...
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Introduction: Positive effects of topical application of honey on open skin wounds have been observed, Mast cell are playing role in normal wound healing and its disturbances but the role of mast cells in wound healing in existence of honey is uncertain. Objective: The aim of this investigation was to study the effects of two times per day topical application of honey on the number of mast cells in skin wounds. Materials and Methods: 33 male rats were randomly divided into experimental and control groups. Under general anesthesia and sterile conditions, one round full thickness skin wound was made on the dorsum of neck of each rat. The diameter of wounds was about 3cm. Unboiled honey was applied topically on wounds twice per day from surgery day until certain days. On the fourth, seventh, and fourteenth days after surgery according to inflammation, proliferation and remodeling phases of wound healing process, samples were obtained from wound tissue and adjacent skin after rats were killed with ether. Samples were prepared for routine histological study and stained with 1% aqueous toluidine blue. Mast cells of wounds were counted and analyzed by Mann Whitney U test. Results: The mean of mast cells was lower in experimental group in three above-mentioned days. The differences were statistically significant on days 4 and 7 (P<0.05 for fourth day, P<0.01 for seventh day, and P>0.05 for fourteenth day). Conclusion: Twice per day application of honey on open full thickness skin wounds could reduce the number of mast cells significantly, in inflammatory and proliferative phases of wound healing.