Paria Baharvand; Ayda Esmaeili; Mohammad Reza Abbasi; Soha Namazi
Abstract
Background: The 12-Item Pruritus Severity Scale (12-PSS) is a multidimensional tool that evaluates pruritus intensity and duration along with an assessment of psychometric properties such as the patient´s mood, daily activities, and sleep pattern. Given its chronicity, uremic pruritus has a substantial ...
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Background: The 12-Item Pruritus Severity Scale (12-PSS) is a multidimensional tool that evaluates pruritus intensity and duration along with an assessment of psychometric properties such as the patient´s mood, daily activities, and sleep pattern. Given its chronicity, uremic pruritus has a substantial impact on quality of life, so it is worth having a valid Persian questionnaire for assessing the various aspects of pruritus. This study was designed to evaluate the validity and reliability of the translated 12-PSS in hemodialysis patients with chronic uremic pruritus.
Methods: Participants in this cross-sectional study were hemodialysis patients with uremic pruritus who were referredto the dialysis departments of three hospitals in Tehran, Iran. Following forward-backward translation of the 12-PSS to and from Persian, we assessed its content validity index (CVI) and reliability. Finally, we asked patients to respond to questions using both the Visual Analog Scale (VAS) and the 12-PSS.
Results: Overall, 195 eligible patients participated in this study. The average age was 55.08 ± 12.34 years. The internalconsistency (Cronbach’s alpha) of the 12-PSS was found to be 0.88, indicating strong consistency. The mean VAS and 12-PSS scores were 6.40 ± 2.63 and 11.52 ± 3.91, respectively, and the correlation between VAS and the total raw points of the pruritus intensity domain of the 12-PSS (questions 9 and 10) was strong(P-value < 0.05, r = 0. 90).
Conclusions: This study showed that the translated form of the 12-PSS questionnaire has acceptable validity and reliability and has a strong correlation with the VAS in assessing pruritus intensity.
Layegh Pouran; Meibodi Naser Tayyebi; Nahidi Yalda; Sepehri Zahra; Nazari Ali; Shakeri Mohammad Taghi
Volume 17, Issue 1 , 2014, , Pages 8-12
Abstract
Background: The description on patients with pigmented back patches is rarely reported in the literature. We decided to study the clinicopathological aspects of these patients for reaching a better understanding of this disease.Method: In this study, the clinicopathological aspects and probable responsible ...
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Background: The description on patients with pigmented back patches is rarely reported in the literature. We decided to study the clinicopathological aspects of these patients for reaching a better understanding of this disease.Method: In this study, the clinicopathological aspects and probable responsible factors in the manifestation of posterior pruritic pigmented patches in patients referred to the dermatology clinic of Qaem University Hospital from October 2007 to September 2009 were surveyed.Result: All 60 patients who were enrolled in our study were female with a mean age of 31.43±9.71 years. Six patients did not consent to biopsy. The most c
Mirnezami Mina; Rahimi Hoda
Volume 13, Issue 1 , 2010, , Pages 12-15
Abstract
Background: Pruritus is one of the most disabling problems in patients with chronic renal failure. It is a distressing symptom with a negative impact on quality of life and is also very frustrating for both patients and their physicians. The pathophysiological mechanisms of pruritus are mainly unknown. ...
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Background: Pruritus is one of the most disabling problems in patients with chronic renal failure. It is a distressing symptom with a negative impact on quality of life and is also very frustrating for both patients and their physicians. The pathophysiological mechanisms of pruritus are mainly unknown. The aim of this study was to identify factors associated with pruritus in these patients. Methods: This cross sectional study was done on 100 patients who were under hemodialysis because of end stage renal disease. In patients who were suffering from uremic pruritus, the severity of pruritus was assessed and the relationship between the presence and severity of pruritus with serum levels of hemoglobin, creatinine, urea, phosphate, calcium, albumin, parathormone hormone (PTH) and alkaline phosphatase was evaluated.Results: One hundred patients (48 women and 52 men) entered this study. Pruritus was found in 45% of the patients. We found a significant relationship between severity of pruritus with age and serum level of phosphate. No significant correlation was found between the severity of pruritus and sex, duration of dialysis, underlying renal disease and serum levels of hemoglobolin, urea, albumin, PTH, alkaline phosphatase, calcium, and creatinine. Conclusions: Pruritus is still a common problem in hemodialysis – dependent patients. Higher serum levels of phosphate seems to be an important factor associated with uremic pruritus.
Guiti Sadeghian; Hengameh Ziai
Volume 10, Suppl.2 , 2007, , Pages 2-2
Abstract
A 30-year-old woman was referred to us with red and firm nodules on upper lateral aspect of left arm. These nodules were present for 15 years without pain but with intense pruritus.She reported uterine leiomyoma in the past, but family history for similar lesions was negative. Blood tests were normal, ...
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A 30-year-old woman was referred to us with red and firm nodules on upper lateral aspect of left arm. These nodules were present for 15 years without pain but with intense pruritus.She reported uterine leiomyoma in the past, but family history for similar lesions was negative. Blood tests were normal, but pelvis ultrasound showed a large uterine leiomyoma.Histologic examination of cutaneous lesions showed proliferation of smooth muscle cells with fascicular pattern in dermis. Pruritus was controlled with oral anti-histamine (loratadine). Plastic surgeons refused to remove the skin lesions due to their location and widespread distribution.
Ramezanpou Afshar; Ramezan Fallah
Volume 10, Issue 3 , 2007, , Pages 236-239
Abstract
Background and aim: Pruritus is a common disabling problem in patients with end stage renal disease. Several studies has recorded the relation between pruritus with hemodialysis in chronic renal failure (CRF) patients. This study was designed to evaluate the effect of hemodialysis on pruritus of patients ...
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Background and aim: Pruritus is a common disabling problem in patients with end stage renal disease. Several studies has recorded the relation between pruritus with hemodialysis in chronic renal failure (CRF) patients. This study was designed to evaluate the effect of hemodialysis on pruritus of patients with CRF.Materials and Methods: After recording the demographic data and the diagnosis of disease by a specialist, 44 patients with CRF undergoing hemodialysis with 44 CRF non-hemodialysis patients were evaluated.Results: Pruritus in case group was 2.8 times of control group (P=0.033). Pruritus in female patients with CRF undergoing hemodialysis was 7.4 times of non-hemodialysis patients (P=0.006). No relation was found between itching and hemodialysis in male patients with CRF.Conclusion: Pruritus is a common problem in CRF patients with hemodialysis and hemodialysis is an important factor in the initiation of pruritus.
Pouran Layegh; Mohammad Javad Mojahedin; Parisa Emamgholitabar Malekshah; Fatemeh Nazemian; Farzaneh Sharifipour; Mohammad Vahedian
Volume 10, Issue 1 , 2007, , Pages 20-25
Abstract
Background and aim: Uremic pruritus is a relatively common and distressing problem for patients with chronic renal failure. Serotonin and histamine have been reported as possible mediators of uremic pruritus. Granisetron, a potent and selective inhibitor of 5-HT3 receptors was developed for relief of ...
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Background and aim: Uremic pruritus is a relatively common and distressing problem for patients with chronic renal failure. Serotonin and histamine have been reported as possible mediators of uremic pruritus. Granisetron, a potent and selective inhibitor of 5-HT3 receptors was developed for relief of chemotherapy induced nausea. There are some studies about effect of Ondansetron in uremic pruritus and recently one case report described relief of renal itch with Granisetron. The aim of our study was to evaluate the effect of Granisetron on uremic pruritus in patients with chronic renal failure under dialysis.Materials and methods: 14 uremic patients under hemodialysis with moderate and severe pruritus were enrolled in this open trial. Patients received Granisetron tablet (1 mg twice a day) for 1 month. Patients were asked to complete a questionnaire assessing the severity of pruritus on twice a day.Results: 77% of the patients responded to the treatment and on the 1st , 2nd and 4th weeks of treatment, the mean values of pruritus score were 23 (range 11-40), 16(range 8-35), 8(range 0-35) points, respectively, while at baseline (before treatment) it was 31 (range 20-35) points (p=0.03). Pruritus disappeared in 7 patients at the end of 4th week, and was mild in 3 others. This effect was maintained during the study. Weekly clinical and laboratory examinations showed no side effects.Conclusion: Granisetron may be an effective, safe and well tolerated drug for the treatment of uremic pruritus in hemodialysis patients.
Y Panahi; SM Davoudi; S Keshavarz; R Sarhang Nejad; A Tajic; MM Naghi Zadeh
Volume 9, Issue 2 , 2006, , Pages 114-121
Abstract
Background and aim: Chronic skin lesions are common late complications of sulfur mustard intoxication which would result in numerous complaints including pruritus, skin dryness and burn feeling. In chemical warfare injured veterans, pruritus is the most common complaint in chronic status with significant ...
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Background and aim: Chronic skin lesions are common late complications of sulfur mustard intoxication which would result in numerous complaints including pruritus, skin dryness and burn feeling. In chemical warfare injured veterans, pruritus is the most common complaint in chronic status with significant effects on patient's quality of life. This study has evaluated efficacy of topical phenol 1% and menthol 1% combination in treatment of pruritus in chemical warfare injured veterans in comparison with placebo.Materials and Methods: This randomized double blind clinical trial was done on chemical warfare injured veterans with mustard gas induced pruritus. Eighty patients were randomly divided to 2 equal groups, one group treated with phenol 1% and menthol 1% combination and other group with placebo for 6 weeks and the therapeutic effects were evaluated according to pruritus scores.Results: Pruritus score was significantly reduced in active group compared to placebo group (P=0.026).Conclusion: Phenol 1% and menthol 1% combination has significant therapeutic effect for mustard gas induced pruritus in chemical warfare injured veterans.
H Ansarin; S Abbasi Moin
Volume 5, Issue 1 , 2001, , Pages 34-38
Abstract
Background: Pruritic skin disorders are one of the most common disorders in elderly. Objective: To find out the prevalence of pruritic skin disorders in the elderly residing in Kahrizak Institute in Tehran. Patients and Methods: In this descriptive, cross sectional survey, all the elderly over 60 years ...
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Background: Pruritic skin disorders are one of the most common disorders in elderly. Objective: To find out the prevalence of pruritic skin disorders in the elderly residing in Kahrizak Institute in Tehran. Patients and Methods: In this descriptive, cross sectional survey, all the elderly over 60 years of age without dementia residing in Kahrizak Institute in Tehran in the first 6 months the year 1379 were studied for the presence of 9 pruritic skin disorders including xerosis, eczema, lichen simplex chronicus, infections, urticaria, insect bite and scabies, psoriasis vulgaris, drug eruption and anogenital pruritus. Questionnaires were completed for persons who complained from pruritus, based on general examinations. Statistical analysis was done by using SPSS/PC software. Results: Out of 734 elderly included in the study, 161 (22%) had pruritus including 89 women (54%) and 72 men (46%). The most common cause of pruritus in both sexes were xerosis or senile pruritus. Eczemas were more common in males and the most common type was seborrheic dermatitis. Diabetes mellitus was the most common systemic disorder associated with pruritus. Conclusion: Pruritic skin disorders are very common in elderly. The responsible organizations must pay attention to this fact and plan better institution and medical facility for this precious group of our society.
