Dadras Mohammad Shahidi; Golfeshan Atefe; Younespour Shima
Volume 18, Issue 2 , 2015, , Pages 51-55
Abstract
Background: It seems that there are similar associated diseases in psoriasis and Lewis (b) negative phenotypes such as diabetesmellitus, cardiovascular events, and metabolic syndrome. Therefore, we decided to evaluate the frequency of Lewis henotypes in patients with chronic plaque type psoriasis. A ...
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Background: It seems that there are similar associated diseases in psoriasis and Lewis (b) negative phenotypes such as diabetesmellitus, cardiovascular events, and metabolic syndrome. Therefore, we decided to evaluate the frequency of Lewis henotypes in patients with chronic plaque type psoriasis. A limited number of studies have been previously conducted in this regard.Methods: Fifty patients and 100 age and gender matched control subjects were selected as the study population. Two milliliter of venous blood was collected from each subject to find out the Lewis phenotype and in subjects with the Le (a-b-) henotype, saliva was collected to determine the secretory status. All individuals with the Le (a-b-) phenotype were typed as non-secretor in their saliva by the hemagglutination inhibition assay; therefore, in this study, Lewis (b) positive individuals were considered as secretor and Lewis (b) negative as non-secretor phenotypes.Results: There was a significant difference in the secretory status or Lewis phenotypes between the two groups. ABH on-secretory status Le (a-b-) and Le (a+b-) together or Lewis b negative phenotypes were found in 78% (39 of 50) of the patients and 26% (26 out of 100) of the healthy controls (P
Shahshahani Mostafa Mirshams; Esmaily Nafiseh; Hallaji Zahra; Kamyab Kambiz; Kalaghchi Bita; Maghsoudnia Gholamreza; Kashani Mansour Nasiri; Narraghi Zahra; Razzaghi Mahmoud; Noormohammadpour Pedram
Volume 11, Issue 2 , 2008, , Pages 73-75
Abstract
Background: Basal cell carcinoma (BCC) is the most common cutaneous malignancy. UV light is an important risk factor for BCC, as well as X-ray and other ionizing radiations. The aim of this study was evaluation and risk factor assessment of BCC cases referred to Razi hospital tumor clinic. Methods: Patients ...
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Background: Basal cell carcinoma (BCC) is the most common cutaneous malignancy. UV light is an important risk factor for BCC, as well as X-ray and other ionizing radiations. The aim of this study was evaluation and risk factor assessment of BCC cases referred to Razi hospital tumor clinic. Methods: Patients referred from general clinics with skin biopsies consistent with Basal Cell Carcinoma were enrolled. A questionnaire including epidemiologic data, risk factor exposure and specification of skin lesions was completed for each patient. Results: From October 2005 to October 2006, a total of 476 patients with cutaneous malignancy referred to Tumor clinic of Razi hospital. Of them, 367 patients had BCC. 215 were male (58%) and 152 were female (42%). Mean age of patients was 62 (±12.7) and 62 (±13.4) years for men and women, respectively. The most common risk factors for BCC were radiotherapy and chronic sun exposure. The most common tumor sites were scalp, nose and ears. Of different clinico-pathologic types, noduloulcerative type was the most common. Conclusion: It seems that radiotherapy is an important risk factor in Iranian BCC patients and it is useful to have a screening program for case finding and treating patients in early stages.
