Paria Baharvand; Ayda Esmaeili; Mohammad Reza Abbasi; Soha Namazi
Abstract
Background: The 12-Item Pruritus Severity Scale (12-PSS) is a multidimensional tool that evaluates pruritus intensity and duration along with an assessment of psychometric properties such as the patient´s mood, daily activities, and sleep pattern. Given its chronicity, uremic pruritus has a substantial ...
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Background: The 12-Item Pruritus Severity Scale (12-PSS) is a multidimensional tool that evaluates pruritus intensity and duration along with an assessment of psychometric properties such as the patient´s mood, daily activities, and sleep pattern. Given its chronicity, uremic pruritus has a substantial impact on quality of life, so it is worth having a valid Persian questionnaire for assessing the various aspects of pruritus. This study was designed to evaluate the validity and reliability of the translated 12-PSS in hemodialysis patients with chronic uremic pruritus.
Methods: Participants in this cross-sectional study were hemodialysis patients with uremic pruritus who were referredto the dialysis departments of three hospitals in Tehran, Iran. Following forward-backward translation of the 12-PSS to and from Persian, we assessed its content validity index (CVI) and reliability. Finally, we asked patients to respond to questions using both the Visual Analog Scale (VAS) and the 12-PSS.
Results: Overall, 195 eligible patients participated in this study. The average age was 55.08 ± 12.34 years. The internalconsistency (Cronbach’s alpha) of the 12-PSS was found to be 0.88, indicating strong consistency. The mean VAS and 12-PSS scores were 6.40 ± 2.63 and 11.52 ± 3.91, respectively, and the correlation between VAS and the total raw points of the pruritus intensity domain of the 12-PSS (questions 9 and 10) was strong(P-value < 0.05, r = 0. 90).
Conclusions: This study showed that the translated form of the 12-PSS questionnaire has acceptable validity and reliability and has a strong correlation with the VAS in assessing pruritus intensity.
Mirnezami Mina; Rahimi Hoda
Volume 13, Issue 1 , 2010, , Pages 12-15
Abstract
Background: Pruritus is one of the most disabling problems in patients with chronic renal failure. It is a distressing symptom with a negative impact on quality of life and is also very frustrating for both patients and their physicians. The pathophysiological mechanisms of pruritus are mainly unknown. ...
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Background: Pruritus is one of the most disabling problems in patients with chronic renal failure. It is a distressing symptom with a negative impact on quality of life and is also very frustrating for both patients and their physicians. The pathophysiological mechanisms of pruritus are mainly unknown. The aim of this study was to identify factors associated with pruritus in these patients. Methods: This cross sectional study was done on 100 patients who were under hemodialysis because of end stage renal disease. In patients who were suffering from uremic pruritus, the severity of pruritus was assessed and the relationship between the presence and severity of pruritus with serum levels of hemoglobin, creatinine, urea, phosphate, calcium, albumin, parathormone hormone (PTH) and alkaline phosphatase was evaluated.Results: One hundred patients (48 women and 52 men) entered this study. Pruritus was found in 45% of the patients. We found a significant relationship between severity of pruritus with age and serum level of phosphate. No significant correlation was found between the severity of pruritus and sex, duration of dialysis, underlying renal disease and serum levels of hemoglobolin, urea, albumin, PTH, alkaline phosphatase, calcium, and creatinine. Conclusions: Pruritus is still a common problem in hemodialysis – dependent patients. Higher serum levels of phosphate seems to be an important factor associated with uremic pruritus.
Ramezanpou Afshar; Ramezan Fallah
Volume 10, Issue 3 , 2007, , Pages 236-239
Abstract
Background and aim: Pruritus is a common disabling problem in patients with end stage renal disease. Several studies has recorded the relation between pruritus with hemodialysis in chronic renal failure (CRF) patients. This study was designed to evaluate the effect of hemodialysis on pruritus of patients ...
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Background and aim: Pruritus is a common disabling problem in patients with end stage renal disease. Several studies has recorded the relation between pruritus with hemodialysis in chronic renal failure (CRF) patients. This study was designed to evaluate the effect of hemodialysis on pruritus of patients with CRF.Materials and Methods: After recording the demographic data and the diagnosis of disease by a specialist, 44 patients with CRF undergoing hemodialysis with 44 CRF non-hemodialysis patients were evaluated.Results: Pruritus in case group was 2.8 times of control group (P=0.033). Pruritus in female patients with CRF undergoing hemodialysis was 7.4 times of non-hemodialysis patients (P=0.006). No relation was found between itching and hemodialysis in male patients with CRF.Conclusion: Pruritus is a common problem in CRF patients with hemodialysis and hemodialysis is an important factor in the initiation of pruritus.
Pouran Layegh; Mohammad Javad Mojahedin; Parisa Emamgholitabar Malekshah; Fatemeh Nazemian; Farzaneh Sharifipour; Mohammad Vahedian
Volume 10, Issue 1 , 2007, , Pages 20-25
Abstract
Background and aim: Uremic pruritus is a relatively common and distressing problem for patients with chronic renal failure. Serotonin and histamine have been reported as possible mediators of uremic pruritus. Granisetron, a potent and selective inhibitor of 5-HT3 receptors was developed for relief of ...
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Background and aim: Uremic pruritus is a relatively common and distressing problem for patients with chronic renal failure. Serotonin and histamine have been reported as possible mediators of uremic pruritus. Granisetron, a potent and selective inhibitor of 5-HT3 receptors was developed for relief of chemotherapy induced nausea. There are some studies about effect of Ondansetron in uremic pruritus and recently one case report described relief of renal itch with Granisetron. The aim of our study was to evaluate the effect of Granisetron on uremic pruritus in patients with chronic renal failure under dialysis.Materials and methods: 14 uremic patients under hemodialysis with moderate and severe pruritus were enrolled in this open trial. Patients received Granisetron tablet (1 mg twice a day) for 1 month. Patients were asked to complete a questionnaire assessing the severity of pruritus on twice a day.Results: 77% of the patients responded to the treatment and on the 1st , 2nd and 4th weeks of treatment, the mean values of pruritus score were 23 (range 11-40), 16(range 8-35), 8(range 0-35) points, respectively, while at baseline (before treatment) it was 31 (range 20-35) points (p=0.03). Pruritus disappeared in 7 patients at the end of 4th week, and was mild in 3 others. This effect was maintained during the study. Weekly clinical and laboratory examinations showed no side effects.Conclusion: Granisetron may be an effective, safe and well tolerated drug for the treatment of uremic pruritus in hemodialysis patients.
N Naderi; M Mahdavi Mazdeh; AR Firooz; M Heydari Seraj
Volume 8, Issue 6 , 2006, , Pages 489-495
Abstract
Background and aim: New modalities in the treatment of end-stage renal disease (ESRD) patients have increased their life expectancy and quality of life. A wide range of cutaneous manifestations are seen in ESRD patients. This study was conducted to determine the prevalence of cutaneous manifestations ...
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Background and aim: New modalities in the treatment of end-stage renal disease (ESRD) patients have increased their life expectancy and quality of life. A wide range of cutaneous manifestations are seen in ESRD patients. This study was conducted to determine the prevalence of cutaneous manifestations in ESRD patients on maintenance hemodialysis in the dialysis department of Imam Khomeini hospital.Materials and Methods: One hundred and four hemodialysis patients on maintenance hemodialysis in April, May, and June 2003 were interviewed and examined for skin problems.Results: Almost all patients had at least one cutaneous lesion. The most common cutaneous findings were changes in skin color and nail disorders (79.8%). The other common cutaneous manifestations were xerosis (74%) and pruritus (51%). Xerosis was more common in those patients with serum calcium level greater than 9.3 gr/dl (P<0.05). Hyperpigmentation was more frequent in patients with urine volume<500 ml (P<0.05) and in those who were more than 24 months on continuous hemodialysis (P<0.05). Pruritus was more common in those patients with a history of drinking alcohol (P<0.05). Nail involvement was seen in all 14 patients who were positive for HCV Ab, but was absent in those 5 patients who were positive for HBs Ag.Conclusion: Cutaneous manifestations are very common in ESRD patients on maintenance hemodialysis.
R Yaghoobi; N Sina; SM Latifi
Volume 5, Issue 3 , 2002, , Pages 29-34
Abstract
Background: There are several reports of different cutaneous manifestations in patients with chronic renal failure (CRF) managed by repeated hemodialysis, in the literature. Objective: This study was conducted to evaluate the prevalence of skin manifestations in patients suffering from CRF who are on ...
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Background: There are several reports of different cutaneous manifestations in patients with chronic renal failure (CRF) managed by repeated hemodialysis, in the literature. Objective: This study was conducted to evaluate the prevalence of skin manifestations in patients suffering from CRF who are on long-term hemodialysis. Patients and Methods: The skin manifestations of 108 CRF patients who underwent hemodialysis in Hemodialysis Center of Ahwaz University of Medical Sciences during the years 2000-2001 were studied by a dermatologist. The duration of dialysis in these patients was between 15 days and 101 months (Mean: 17.04 mo.). Results: All of the patients had at least one cutaneous sign or symptom. The most common finding was skin discoloration (77.7%). Other findings were nail changes (75%), xerosis (60.1%), Pruritus (58.3%), ecchymosis (25.9%) and acquired perforating disorder (1.8%). There was no significant correlation between these findings and sex, age, duration of dialysis and underlying disease. Conclusion: Cutaneous manifestations are common findings among CRF patients who are on long-term hemodialysis and dialysis possibly can affect the frequency of these findings.