Saman Ahmad Nasrollahi; Zaynab Variji; Zahra Ghasemi; Somayeh Yadangi; Aniseh Samadi; Alireza Firooz
Abstract
Background: Cellulite is a cosmetic problem, especially in women. We compared the safety and efficacy of a herbal anti-cellulite lotion with a placebo in a randomized, double-blind, right-left comparison clinical trial.Methods: Ten healthy women (22-58 years) with cellulite (grades 2-4) participated ...
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Background: Cellulite is a cosmetic problem, especially in women. We compared the safety and efficacy of a herbal anti-cellulite lotion with a placebo in a randomized, double-blind, right-left comparison clinical trial.Methods: Ten healthy women (22-58 years) with cellulite (grades 2-4) participated in this study. The anti-cellulite lotion and placebo were applied twice daily on the thighs and buttocks for two months. Treated areas were photographed, and the thigh circumference, subcutaneous fat thickness, and dermal echo density were assessed and compared before and after the treatment. The satisfaction of the participants was also assessed.Results: A comparable improvement in cellulite grade was detected by a blinded dermatologist on both treatment sides. Cellulite improved much in one participant, improved in six, and did not change in three participants. The dermis thickness increased compared with placebo after two months (P = 0.046). A significant reduction was observed in subcutaneous fat thickness on the treated side (P = 0.03). However, the decrease was not significant on the placebo site. There was an increase in the echo density of the dermis in the treatment site, though it was not statistically significant. Both products were well tolerated, and none of the participants experienced skin burning or itching.Conclusion: The studied anti-cellulite lotion reduced the thickness of subcutaneous fat and increased the dermis thickness without serious adverse effects.
Nasrollahi Saman Ahmad; Hasanzadeh Hournaz; Ajami Marjan; Ameri Setareh; Variji Zeinab; Komeili Ali; Firooz Alireza
Volume 18, Issue 4 , 2015, , Pages 145-150
Abstract
Background: Cellulite is a common disease whose exact mechanism is unknown. This study was aimed to assess the safety and efficacy of an anti-cellulite preparation compared with placebo in a randomized double-blind, right-left comparison clinical trial.Methods: Twelve healthy women aged 22 to 58 years ...
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Background: Cellulite is a common disease whose exact mechanism is unknown. This study was aimed to assess the safety and efficacy of an anti-cellulite preparation compared with placebo in a randomized double-blind, right-left comparison clinical trial.Methods: Twelve healthy women aged 22 to 58 years with mild to moderate cellulite on their thighs and buttocks participated in this trial. The anti-cellulite preparation (Three O cream, Pouya Varzan Tejarat Sepahan Co., Iran) and an identical placebo were randomly applied on the right or left thigh and buttock twice a day for 2 months. The mentioned areas were photographed and the circumference, subcutaneous fat thickness, and dermis density and thickness were measured before and after treatment. A satisfaction questionnaire was completed by all volunteers to assess their satisfaction with the efficacy of treatment on each side.Results: There was no significant difference between active and placebo treatment sides in any of measurements. About 90% of participants had an overall satisfaction of 5 and more than 5 based on a 0 to 10 visual analogue scale on the side of anti-cellulite cream. This score was similar on the sides treated with placebo and the active product.Conclusion: Although Three O cream provided more satisfaction in volunteers than placebo, the objective measurements did not show any difference between them.
