Behnam Avandi; Mehdi Ghahartars; Navid Moradi Kashkooli; Najmeh Ahramiyanpour; Mohammad Mahdi Parvizi
Abstract
Erythroderma or generalized scaling dermatitis is a condition marked by redness and scaling of more than 90% of the body surface. This study aimed to review the epidemiological and clinical features of erythroderma patients hospitalized in the Dermatology Ward of Shahid Faghihi Hospital, Shiraz, Iran. ...
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Erythroderma or generalized scaling dermatitis is a condition marked by redness and scaling of more than 90% of the body surface. This study aimed to review the epidemiological and clinical features of erythroderma patients hospitalized in the Dermatology Ward of Shahid Faghihi Hospital, Shiraz, Iran. This retrospective cross-sectional was conducted from 2001 to 2017 using patient records. All patients with a diagnosis of erythroderma on record were included in the survey, and those whose data were missing or were not compatible with the clinical diagnosis were excluded. Data were analyzed with SPSS version 22 and Stata version 14.2. Overall, 217 erythroderma patients were admitted to this ward, including 119 (54.8%) men and 98 (45.2%) women. The mean age of the patients was 47.27 ± 19.68 years (range: 4-92 years). Moreover, the most frequent cause of erythroderma was drug reaction (67%); lamotrigine, with a frequency of 12 patients, was the most prevalent prescribed medication in patients with drug reaction-induced erythroderma. The mean duration of hospital stay was 6.64 ± 4.50 days; this parameter was directly associated with the erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) level. Pruritus (41.9%) and fever (15.2%) were the most frequent clinical manifestations among these patients. As erythroderma is a dermatologic condition that medications can induce, patients should be informed about the warning signals and course of the disease before certain medications are prescribed.
Naser Tayebi-Meybodi; Zari Javidi; Habib-Allah Esmaili; Yalda Nahidi
Volume 10, Issue 2 , 2007, , Pages 135-141
Abstract
Background and aim: The stroma of basal cell carcinoma (BCC) is rich in mast cells. Morpheaform BCC has been reported to contain much more mast cells than the other types of BCC, but their significance remains unknown. In this study we investigated the significance of mast cells related to BCC and possible ...
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Background and aim: The stroma of basal cell carcinoma (BCC) is rich in mast cells. Morpheaform BCC has been reported to contain much more mast cells than the other types of BCC, but their significance remains unknown. In this study we investigated the significance of mast cells related to BCC and possible relationship between increased number of mast cells and clinical and histological parameters including the patient's age, sex, subtype of BCC and severity of peritumoral inflammation.Materials and methods: In this retrospective study, a total of 50 BCC specimens either biopsied or excised were examined histologically. H & E stained slides were examined under light microscopy and the severity of inflammation was assessed subjectively and graded as mild, moderate or severe. Then biopsy specimens were stained with Giesma to identify mast cells. Clinical data including sex and age were obtained form patients records. Finally the data were analysed by t test, Mann-Whitney and ANOVA by SPSS software and pConclusion: Our results support previous reports indicating that mast cells may have a contributory role in defining the subtype of BCC and degree of its aggressiveness. It seems that mast cells have a preventive role against aggression of BCC, as we found more mast cells in superficial BCC than deep ones.