Mohammad Radmanesh; Nasibeh Sohrabian; Ramin Radmanesh
Volume 16, Issue 4 , 2013, , Pages 159-161
Abstract
The patients with universal vitiligo and residual pigmented patches usually do not benefit from available repigmenting methods and are better scheduled for depigmentation by medical, laser,and or freezing procedures. A 37-year-old lady with universal vitiligo and remaining pigmentation ...
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The patients with universal vitiligo and residual pigmented patches usually do not benefit from available repigmenting methods and are better scheduled for depigmentation by medical, laser,and or freezing procedures. A 37-year-old lady with universal vitiligo and remaining pigmentation in the left anterior chest wall, both ventral forearms, and diffuse mottled depigmentation of the face was scheduled for facial depigmentation by 532 nm Q-switched Nd-YAG laser. All residual pigmented facial areas were treated uniformly. Two months after laser therapy, we paradoxically observed considerable repigmentation of the treated areas with only some remaining scattered and round depigmented patches. Through an unknown mechanism, a true reverse Koebner phenomenon with its resultant repigmentation rather than depigmentation was observed in our patient.
Abbasi Ali; Toossi Parviz; Shakoei Safoura; Abolhasani Ehsan; Younespour Shima
Volume 16, Issue 3 , 2013, , Pages 83-88
Abstract
Background: Different modalities have been tried in order totreat stable vitiligo. Culturing melanocytes is time consumingand expensive. Therefore, new methods using autologousmelanocytes are sought. We aimed to compare the mixed nonculturedautologous melanocytes of the outer root sheath andthe bulge ...
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Background: Different modalities have been tried in order totreat stable vitiligo. Culturing melanocytes is time consumingand expensive. Therefore, new methods using autologousmelanocytes are sought. We aimed to compare the mixed nonculturedautologous melanocytes of the outer root sheath andthe bulge area of hair follicle transplantation plus dermabrasionwith dermabrasion alone in stable generalized vitiligo patchesrepigmentation.Method: Eight patients with stable generalized vitiligo wererecruited. Two patches were selected and assigned to one of thestudy groups: one was treated with dermabrasion alone, andthe other was treated with dermabrasion and transplantation.Uncultured melanocytes were extracted from the patients’ hairfollicle outer root sheath and bulge. The patches were assessedmonthly for the next six months. The primary outcome was todetermine the percentage changes of the depigmented patchesfrom the baseline.Result: Although the repigmentation changes were statisticallysignificant in transplantation patches, there was only one patchwith good and another with fair pigmentation. Furthermore,seven patches without and one patch with poor pigmentationwere observed as control lesions. The transplanted patchesdemonstrated a significantly better repigmentation rate in contrastto their controls (p=0.03).Conclusion: Although this method is fast and economic, theclinical response was not satisfactory.
Maleki Masoud; Javidi Zari; –rad Mohammad Ebrahimi; Hamidi Hamid
Volume 11, Issue 2 , 2008, , Pages 55-59
Abstract
Background: Surgical treatments of vitiligo are punch grafting, blister grafting, flip-top transplantation, split skin grafting, etc aiming at rebuilding of melanocytic population in those patients who do not respond to medical treatment . The objective of this study was determination of efficacy of ...
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Background: Surgical treatments of vitiligo are punch grafting, blister grafting, flip-top transplantation, split skin grafting, etc aiming at rebuilding of melanocytic population in those patients who do not respond to medical treatment . The objective of this study was determination of efficacy of blister grafting technique in the treatment of vitiligo. Methods: This study was done on 10 patients with vitiligo of face and /or distal extremities who had received different medical treatments including PUVA and had not responded, and their diseases were stable. Blister in recipient site was created by cryotherapy and in donor site by using vacuum device. Then donor site blister was transferred to the recipient site and both sites were covered by dressing. Results: 10 patients (8 females & 2 males) with mean age of 31.2±11.4 years entered the study. After 1-6 weeks, first signs of repigmentation were observed and after 4 months complete repigmentation occured in 7 patients (70%) In two patients, a repigmentation of more than 50% was observed while in one patient no pigmentation was seen which was related to errors in surgical technique. Conclusion: Blister grafting surgery in limited patches of vitiligo which have not responded to medical treatments gives excellent results of prolonged repigmentation without any scar formation.