Saman Ahmad Nasrollahi; Aniseh Samadi; Fatemeh Samii; Chao Yuan; Alireza Firooz
Abstract
Background: Brimonidine tartrate is an alpha-2 adrenergic receptor agonist approved for treating rosacea. This study aimed to assess the efficacy and safety of a brimonidine gel in rosacea patients with skin types III and IV.
Methods: This study was a phase II before-after clinical study in 20 patients ...
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Background: Brimonidine tartrate is an alpha-2 adrenergic receptor agonist approved for treating rosacea. This study aimed to assess the efficacy and safety of a brimonidine gel in rosacea patients with skin types III and IV.
Methods: This study was a phase II before-after clinical study in 20 patients with moderate to severe rosacea treated with brimonidine 0.33% gel. Clinician’s Erythema Assessment (CEA), Patients’ Self-Assessment (PSA), skin erythema (ΔE), lightness (ΔL), and biophysical parameters were measured before treatment and 4 and 8 weeks later. Ultrasound parameters were also measured at the same time points.
Results: Eighteen patients completed the study. CEA and PSA decreased significantly from 3.05 to 2.10 and 2.15 after 4 weeks and 2.20 and 2.15 after 8 weeks, respectively (P<0.01 for both). Furthermore, ΔE and ΔL, as well as the skin erythema index, improved after 4 weeks of treatment. The skin echo density of both the epidermis and dermis also increased after 8 weeks (P<0.05). During the study, no serious adverse events occurred other than some reports of temporary moderate redness.
Conclusion: Daily application of brimonidine 0.33% gel is safe and effective for the treatment of rosacea in darker skin types.
Ahmad Ibrahim Yahaya; Akmal Hisham; Shah Jumaat Mohd Yussof; Chooi Lai Kuan; Salina Ibrahim
Abstract
Once popularly known as whiskey nose or rum blossom, rhinophyma is a permanent thickening of the nasal skin composed of confluent erythematous papules and prominent follicles. The etiology is not fully known, but many authors describe rhinophyma as the fourth stage of acne rosacea, a chronic inflammatory ...
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Once popularly known as whiskey nose or rum blossom, rhinophyma is a permanent thickening of the nasal skin composed of confluent erythematous papules and prominent follicles. The etiology is not fully known, but many authors describe rhinophyma as the fourth stage of acne rosacea, a chronic inflammatory cutaneous disease characterized by erythema, telangiectasia, papules, pustules, and edema. It is benign yet disfiguring and can be stigmatizing. Here, we report the case of a 54-year-old man who presented with a mass on the nose that had slowly grown over the prior two years. He had a history of acne, treated with isotretinoin 10 mg daily by a dermatologist, one year before the onset of this mass. Examination from the frontal view revealed asymmetric, diffuse, multilobulated skin hypertrophy over the middle and lower nasal vault. On the basal view, there was a 10 x 7 mm epithelizing ulceration over the right alar rim. He underwent a partial-thickness resection of the hypertrophied nasal skin, and the resulting wound was left to heal via secondary intention, with a good cosmetic outcome.
Dhaher Samer A; Alhamdi Dhoha Kh
Abstract
Background: Rosacea is a chronic inflammatory disease of unknown etiology. Few studies have been published on the use of oral ivermectin in the treatment of the inflammatory subset of rosacea. The aim of the present research was to evaluate the efficacy and safety of oral ivermectin prescribed for a ...
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Background: Rosacea is a chronic inflammatory disease of unknown etiology. Few studies have been published on the use of oral ivermectin in the treatment of the inflammatory subset of rosacea. The aim of the present research was to evaluate the efficacy and safety of oral ivermectin prescribed for a series of patients with inflammatory rosacea.
Methods: On a weekly basis, 29 patients with papulopustular rosacea were orally given ivermectin at a dose of 200 µg/kg before meal for three consecutive weeks. Subjects were evaluated weekly and during the follow-up period for two successive treatment-free months.
Results: After 3 doses of ivermectin, there was a significant reduction in the total count of inflammatory lesions compared to the base line (the mean was reduced from 51.6±27.4 to 21±14.7) (P<0.05). At the end of the two-month follow-up period, more reduction was observed in inflammatory lesions (mean was reduced to 9.3±7), and 62% of the patients showed excellent responses to the treatment (≥ 80% reduction in the lesions). Nausea was reported in 10%.
Conclusion: A three-week use of oral ivermectin is an effective, safe, and well-tolerated approach to treating inflammatory rosacea .
Abbas Zamanian; Ahmadreza Mobaien
Volume 13, Issue 4 , 2010, , Pages 128-130
Abstract
Background: Rosacea is a chronic skin disease with an unknown etiology. Some reports have suggested an increased prevalence of Helicobacter pylori infection in rosacea patients, but it is controversial. This study was designed to compare the prevalence of H. pylori and serological cag A+ species between ...
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Background: Rosacea is a chronic skin disease with an unknown etiology. Some reports have suggested an increased prevalence of Helicobacter pylori infection in rosacea patients, but it is controversial. This study was designed to compare the prevalence of H. pylori and serological cag A+ species between the rosacea patients and the healthy control group. Methods: This case-control study was performed on 30 rosacea patients and 60 healthy individuals as the control group. The results were reported based on clinical and serological enzymelinked immunosorbent assay IgG antibody and cag A examination in two groups. Results: Mean age of the rosacea patients and the control group was 45.8 ± 14.05 and 41.4 ± 12.3 years respectively and 56.7% of the patients and 86.2% of controls were infected by H. Pylori (P=0.002). Furthermore, cag A+ was seen in 53.5% of the patients and 50% of the controls (P=0.23). Conclusion: This study showed a reduction in the prevalence of Helicobacter Pylori in acne rosacea patients compared to other studies in the world. The authors believe that it is necessary to conduct more studies to demonstrate the exact prevalence of this organism in Iranian rosacea patients.
P Toosi; L Gachkar; M Rostami Moghaddam
Volume 5, Issue 4 , 2002, , Pages 28-31
Abstract
Background: The prevalence of Helicobacter pylori (H. pylori) infection in patients with rosacea is reported from 50 to 90 percent, which suggests the possibility of the role of this organism in pathogenesis of rosacea. Objectives: Evaluation of relationship between H. pylori infection and rosacea. Patients ...
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Background: The prevalence of Helicobacter pylori (H. pylori) infection in patients with rosacea is reported from 50 to 90 percent, which suggests the possibility of the role of this organism in pathogenesis of rosacea. Objectives: Evaluation of relationship between H. pylori infection and rosacea. Patients and Methods: In this case-control study, 30 patients referred to skin clinics of Boo-Ali and Loghman Hakim hospitals in Tehran were compared with 30 individuals of similar sex and age who had not rosacea (Control group). Serologic tests for H. pylori infection (IgG and IgA), and also urea breath test were done. The results were compared using chi-square test with 95% confidence interval and P<0.05 was considered as significant. Results: No significant differences were seen between patients with rosacea and control group in having IgA (60% in case group, 40% in control group), IgG (76.6% in case group, 53.3% in control group) and positive breath test. Conclusion: More extensive research about possible relationship between H. pylori infection and rosacea is recommended.
