Saman Ahmad Nasrollahi; Taraneh Yazdanparast; Setareh Ameri; Shadi Marami Zonouz; Mansour i Nassiri-Kashan; Alireza Firooz
Volume 20, Issue 1 , 2017, , Pages 1-5
Abstract
Background: Various fillers have been used for the correction of nasolabial folds. This study investigated the efficacy and safety assessment of two hyaluronic acid (HA) fillers on moderate nasolabial folds. Methods: This study randomized 10 volunteers, aged 35 to 49 years, with moderate nasolabial folds. ...
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Background: Various fillers have been used for the correction of nasolabial folds. This study investigated the efficacy and safety assessment of two hyaluronic acid (HA) fillers on moderate nasolabial folds. Methods: This study randomized 10 volunteers, aged 35 to 49 years, with moderate nasolabial folds. Volunteers received injections of HA A and HA B gels into the right or left skin folds. The volume and surface of nasolabial folds were analyzed using CSI computer software and high frequency ultrasonography of these folds before, and 2, 12, and 24 weeks after the injection. The obtained data were analyzed using SPSS software version 20. P≤0.05 was considered significant. Results: Evaluation of the nasolabial folds before and after treatment showed significant reduction in volume of wrinkles 24 weeks after injection in both the HA gel A (-29.93±32%, P=0.022) and gel B (-23.60±26%, P=0.019). The surfaces of the wrinkles significantly decreased 24 weeks after injection of HA gel A (-29.90±31%, P=0.012) and gel B (-21.96±26%, P=0.026). Conclusion: These HA fillers provided a significant, long-lasting correction of moderate nasolabial folds. Overall, we observed no statistically significant differences in any of the measurements between the 2 gels. However, there were more observed changes made by gel A compared to gel B.
Kashani Mansour Nassiri; Estarabadi Ali Rajabi; Zartab Hamed; Khoshpouri Parisa; Khoshpouri Pegah; Hosseini Hamed; Tavakoli Amir Hossein; Firooz Alireza
Volume 18, Issue 3 , 2015, , Pages 97-103
Abstract
Background: With aging, the facial folds, grooves, and sagging tissue become more prominent. It is haracterized by loss of the collagen mass in the dermis and an increased array of elastin whirls in the deeper dermis. The aim of this study was to determine whether correction of nasolabial folds could ...
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Background: With aging, the facial folds, grooves, and sagging tissue become more prominent. It is haracterized by loss of the collagen mass in the dermis and an increased array of elastin whirls in the deeper dermis. The aim of this study was to determine whether correction of nasolabial folds could be achieved using an allogeneic collagen product. Methods: Nine healthy volunteers participated in this beforeafter, pilot clinical trial. Human allogeneic collagen (Collagel, Kimia Teb Rahavard Co., Tehran, Iran) was injected in both nasolabial folds of the volunteers. Skin hydration was measured using the Corneometer® 580 device (CK GmbH, Cologne, Germany). Ultrasonic dermal changes were measured using an ultrasonography device (22 MHz, TPM, Germany) before and 24 weeks after the injection. One independent investigator assessed the efficacy using standardized photographs before and 24 weeks after injections. The patients’ satisfaction rate was also evaluated.Results: All patients showed improvement in wrinkles and the mean satisfaction rate on a 0-10 VAS was 7.4±0.5. The hydration of the stratum corneum increased from 32.32±13.54 to 52.61±12.55 and the echo-density of the dermis increased from 8.05±3.18 to 9.55±3.36 μm 24 weeks after the injection (P≤0.05). No treatmentrelated adverse events were reported.Conclusion: Collagel is an effective filler that can provide a safe and effective correction of the nasolabial folds. This correction lasts for at least 24 weeks on ultrasound evaluations. Further larger blind-randomized controlled clinical trials are required to pave the way for suggesting it as a possible therapeutic option.