Beena Gidwani; RN Alaspure; NJ Duragkar; Vijay Singh; Prakash Rao S; SS Shukla
Volume 13, Issue 4 , 2010, , Pages 122-127
Abstract
Background: We studied the efficacy of an herbal semisolid formulation, prepared from hexane extract of seeds of Psoralea Corylifolia, which has anti-inflammatory and antimicrobial properties, in the treatment of eczema. Methods: Extraction of seeds of Psoralea Corylifolia was done in Soxhlet apparatus ...
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Background: We studied the efficacy of an herbal semisolid formulation, prepared from hexane extract of seeds of Psoralea Corylifolia, which has anti-inflammatory and antimicrobial properties, in the treatment of eczema. Methods: Extraction of seeds of Psoralea Corylifolia was done in Soxhlet apparatus using hexane as the solvent. Furthermore, Oil in Water (O/W) cream was formulated with a stearic acid base and was evaluated for various parameters like pH, viscosity, rheology, etc. This cream was then utilized for the treatment of eczema. Results: The formulation was effective in treating eczema in this open clinical trial. Thirty patients suffering from eczema were treated for 1 month, out of whom twenty five completed the study. The patients recovered from their symptoms using the cream twice daily and were assessed every week for 1 month. It was observed that the symptoms score reduced at the end of 2 weeks onwards. At the end of the study, the symptom score for eczema reduced from 6.367±1.098 to 0.333 ± 0.279 for length of the lesion, from 1.333 ± 0.994 to 0.165 ± 0.087 for exudation rate, and from 2.567 ± 0.504 to 0.165 ± 0.132 for the rate of itching. Conclusion: The plant Psoralea Corylifolia has been used in treatment of various skin disorders, and the present research concluded that this plant could be effectively used for the treatment of eczema.
ZB Mousavi; M Meshki; A Hemmati; MS Veisi; R Rafiei
Volume 9, Issue 3 , 2006, , Pages 260-263
Abstract
Background and aim: Improvement of wound healing in normal subjects and in chronic ulcers has been always desired. The availablity and acceptability of herbal medicine led us to study the effect of topical 10% mucilage of quince seed in human skin.Materials and Methods: This double-blind clinical trial ...
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Background and aim: Improvement of wound healing in normal subjects and in chronic ulcers has been always desired. The availablity and acceptability of herbal medicine led us to study the effect of topical 10% mucilage of quince seed in human skin.Materials and Methods: This double-blind clinical trial has been conducted on 34 patients referring to Imam Hospital, clinic of dermatology for elective surgery or excisional biopsy of benign lesions. The patients were divided into 3 groups and their lesions were treated with either 10% quince mucilage or eucerin or left untreated. The wound surface was measured on the days 0, 3, 5, 7, 14 and 20. The data were analyzed by ANOVA.Results: The mean duration of complete healing was 10.72 days in quince mucilage, 15.62 days in eucerin, and 16.7 days in untreated group (P<0.05).Conclusion:10% quince mucilage ointment improved wound healing. Further and larger studies are needed to evaluate the quince mucilage effect and its possible application for patients suffering form chronic ulcers.
