Saeedeh Farajzadeh; Mahin Aflatoonian; Saman Mohammadi; Hamid Sharifi; Maryam Khalili
Abstract
Background: Hyperhomocysteinemia and vitamin D deficiency maybe involved in the pathogenesis of vitiligo. This study comparedthe serum levels of vitamin D, homocysteine, vitamin B12, andfolic acid between vitiligo-affected children and healthy children.Methods: Using a case-control design, 30 children ...
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Background: Hyperhomocysteinemia and vitamin D deficiency maybe involved in the pathogenesis of vitiligo. This study comparedthe serum levels of vitamin D, homocysteine, vitamin B12, andfolic acid between vitiligo-affected children and healthy children.Methods: Using a case-control design, 30 children with vitiligoand 30 age and sex-matched healthy children were enrolledfrom April 2018 to August 2020. Serum levels of vitamin D,homocysteine, vitamin B12, and folic acid were analyzed in bothgroups during the same season of the year. Additionally, theassociation between serum levels of these factors with demographicand clinical features of the children (collected by interview andphysical examination) was evaluated. Data were analyzed usingthe independent T-test, Fisher’s exact test, and chi-squared test.Results: The vitiligo group had significantly lower vitamin Dand folic acid serum levels compared with the control group[95% CI -19.87 to -2.96 and -4.15 to -4.18, respectively]. Amongpatients, the vitamin D level was negatively correlated with age(r = -0.459, P = 0.011) and disease duration (r = -0.373, P = 0.042).Moreover, there was a significant association between vitiligoactivity and serum homocysteine levels (P = 0.027).Conclusion: Routine measurement of vitamin D and folic acidserum levels might be suggested, especially in children withlong-standing disease. Monitoring the homocysteine level maybe beneficial, particularly in children with progressive vitiligo.
Ghiasi Maryam; Lajevardi Vahide; Farahbakhsh Abbas
Volume 18, Issue 2 , 2015, , Pages 45-50
Abstract
Background and Aim: Vitiligo is a hypopigmentation disorder of the skin that is associated with depression and an impaired quality of life. There has been conflicting reports on the association between the disease and the serum levels of homocysteine, vitamin B12, and folic acid.In this study,serum levels ...
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Background and Aim: Vitiligo is a hypopigmentation disorder of the skin that is associated with depression and an impaired quality of life. There has been conflicting reports on the association between the disease and the serum levels of homocysteine, vitamin B12, and folic acid.In this study,serum levels of homocysteine, vitamin B12, and folic acid were evaluated in patients with vitiligo.Methods: Thirty patients with vitiligo and 30 age- and sex-matched healthy controls were recruited. Venous blood samples wereobtained from the study subjects and the levels of homocysteine, vitamin B12, and folic acid were measured. Data were analyzedusing non-parametric statistical tests.Results: No significant differences were found in the levels of serum homocysteine, vitamin B12, and folic acid between vitiligo patients and healthy controls. Moreover, there were no associations between these factors and age, body weight, gender,as well as the extent, duration, and type of vitiligo.Conclusion: It seems that vitiligo is not related to serum levels of homocysteine, vitamin B12, and folic acid.
Yalda Nahidi; Naser Tayyebi Meibodi; Habibollah Esmaili
Volume 17, Issue 3 , 2014, , Pages 81-84
Abstract
Background: Vitiligo is a common cutaneous depigmentation disorder caused by the destruction of melanocytes. The exact etiopathogenesis of this disorder is not well known, but a complex of genetic, immunologic, inflammatory, and cytotoxic factors have been implicated. According to ...
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Background: Vitiligo is a common cutaneous depigmentation disorder caused by the destruction of melanocytes. The exact etiopathogenesis of this disorder is not well known, but a complex of genetic, immunologic, inflammatory, and cytotoxic factors have been implicated. According to reports on the role of vitamin B12 and folic acid deficiency as important co-factors in the metabolism of homocysteine, we expected an increase in homocysteine levels in patients with vitiligo; therefore, our aim was to investigate the serum levels of homocysteine in Iranianpatients with vitiligo.Method: Forty patients with vitiligo and 40 healthy controls matched for age and sex were studied. After exclusion of cases with diseases that could affect the homocysteine level, serum homocysteine levels were measured by ELISA.Result: Males comprised 57.5% of the participants in both groups and 42.5% were female. The mean age of the patients was 24.68 ± 12.44 years. The level of homocysteine in the case andcontrol groups was 18.56 ± 5.69 and 10.19 ± 4.40, respectively, which was significantly higher in patients with vitiligo (P ? 0.001). There was no correlation between homocysteine levels and age,sex, history of previous treatment, duration of disease, and the extent of body surface involvement. Serum homocysteine levels in patients with regressive vitiligo (13.8) were lower thanprogressive (18.4) and stable (20.4) cases (P = 0.05).Conclusion: We found that the increase in serum homocysteine level in patients genetically susceptible to vitiligo could be a predisposing factor for the development of vitiligo. The serumhomocysteine level is associated with disease activity, and may be used as a prognostic factor for disease activity.
Shahidi-Dadras Mohammad; Farnaghi Ali; Tehranchinia Zohreh; Rahimi Hoda; Saeedi Marjan; Ghaemi Marjan
Volume 13, Issue 3 , 2010, , Pages 67-70
Abstract
Introduction: Pemphigus vulgaris is an autoimmune blistering disease of the skin and mucous membrane. Antiphospholipid antibodies are a group of autoantibodies found in patients with autoimmune diseases. Due to the risk for thrombotic events in autoimmune diseases, we decided to evaluate the correlation ...
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Introduction: Pemphigus vulgaris is an autoimmune blistering disease of the skin and mucous membrane. Antiphospholipid antibodies are a group of autoantibodies found in patients with autoimmune diseases. Due to the risk for thrombotic events in autoimmune diseases, we decided to evaluate the correlation between pemphigus vulgaris and predictive elements of atherothrombosis including antiphospholipid antibodies and homocysteine. Methods: IgG and IgM anticardiolipin antibodies, IgG anticardiolipinbeta 2 glycoprotein I, lupus anticoagulant and total homocysteine were evaluated in the serum of 39 new cases of pemphigus vulgaris and healthy matched controls. Results: The prevalence of antiphospholipid antibodies, lupus anticoagulant and total homocysteine in pemphigus vulgaris patients showed no significant difference with healthy controls. Conclusion: Pemphigus vulgaris seems not to be similar to some other organ specific autoimmune diseases in which there is an increase in atherothrombotic factors including antiphospholipid antibodies and homocysteine.
Malekzad Farhad; Qeisari Mehdi; Nasiri Soheila; Rahmati-Roudsari Mohammad; Saeedi Marjan; Sarlak Mojdeh
Volume 12, Issue 1 , 2009, , Pages 9-12
Abstract
Background: An elevated homocysteine level is an independent risk factor for cardiovascular disorders. Psoriatic patients have an increased risk of cardiovascular diseases; In addition, hyperhomocysteinemia is a complication of methotrexate treatment. We undertook a study to evaluate the plasma levels ...
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Background: An elevated homocysteine level is an independent risk factor for cardiovascular disorders. Psoriatic patients have an increased risk of cardiovascular diseases; In addition, hyperhomocysteinemia is a complication of methotrexate treatment. We undertook a study to evaluate the plasma levels of homocysteine, vitamin B12 and folate in patients with psoriasis before and after short-term low-dose methotrexate treatment. Methods: Twenty six patients with psoriasis were recruited. The plasma levels of homocysteine, vitamin B12 and folate were evaluated before and 8 weeks after methotrexate therapy (in the peak of methotrexate effect). Results: No significant difference was found between the plasma profile of homocysteine, vitamin B12 and folate before and after methotrexate treatment. Conclusion: In the short-term treatment of psoriasis, methotrexate does not increase homocysteine level.
