Neda Hosseini Sarani; Mehran Ataei; Tannaz Akbari Kolagar; Elaheh Heydari; Maryam Farzaneh; Amir Anbiyaiee
Abstract
Skin cancer is the out-of-control growth of skin cells that can be divided into keratinocyte carcinoma (non-melanoma) and malignant melanoma. Basal cell carcinoma (BCC) and squamous cell carcinomas (SCC) are the most common forms of keratinocyte carcinoma that may grow to involve other parts of the body. ...
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Skin cancer is the out-of-control growth of skin cells that can be divided into keratinocyte carcinoma (non-melanoma) and malignant melanoma. Basal cell carcinoma (BCC) and squamous cell carcinomas (SCC) are the most common forms of keratinocyte carcinoma that may grow to involve other parts of the body. These cancers are caused by exposure to ultraviolet (UV) light, toxic substances, and a family history of skin problems. Different signaling pathways are likely to be involved in skin cancer. The TP53 gene (the gene coding for cellular tumor protein p53) is among the most diverse and complex molecules involved in cellular functions. The p53 pathway can initiate DNA replication, modulate cell cycle events, and interact with tumor suppressor genes (TSGs). Mutations in TP53 can occur in numerous human cancers, leading to cellular immortalization, inappropriate proliferation, and genomic instability. TP53 plays a big role in both melanoma and non-melanoma skin cancers. Despite the intensive investigation to clarify the impact of TP53 mutations in the induction of skin cancer, much remains to be elucidated. In this mini-review, we will discuss the protective role of p53 as a bona fide tumor suppressor gene in human skin cancers.
Mina Almasi-Nasrabadi; Reza M Robati
Abstract
Basal cell carcinoma (BCC) is the most common form of nonmelanoma skin cancer. A review of the literature revealed only a few reports of BCC on the auricle or conchal bowl, usually occurring in elderly patients. Herein, we report an exceptional case of BCC in a young man with an unusual anatomical location ...
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Basal cell carcinoma (BCC) is the most common form of nonmelanoma skin cancer. A review of the literature revealed only a few reports of BCC on the auricle or conchal bowl, usually occurring in elderly patients. Herein, we report an exceptional case of BCC in a young man with an unusual anatomical location of the tumor as a solitary erythematous to black-colored plaque located in the conchal bowl of his right ear. By thoroughly reviewing the literature, there was no other documented case of BCC located in the conchal bowl of the ear of a young adult. Dermatologists should be aware that skin tumors may also occur in uncommon anatomical locations and with unusual presentations in the young population, even if they have no known predisposing factor. Unusual presentations make clinical suspicion of skin tumors very difficult, so these lesions can easily be missed. Early diagnosis can prevent further growth, extensive destruction, and severe consequence of invasive treatments.
Tazval Jafar; Ghaffari Mohtasham; Robati Reza M
Volume 16, Issue 4 , 2013, , Pages 121-127
Abstract
Background: Skin cancers are among the most prevalent malignancies in Iran. According to statistics, it is the most common cancer in the population of Ilam, west of Iran. The present study aimed to assess threat appraisal of skin cancer among rural farmers of Ilam in 2013-2014.Method: In this cross-sectional ...
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Background: Skin cancers are among the most prevalent malignancies in Iran. According to statistics, it is the most common cancer in the population of Ilam, west of Iran. The present study aimed to assess threat appraisal of skin cancer among rural farmers of Ilam in 2013-2014.Method: In this cross-sectional study, we used multistage random sampling. We collected the data through distribution of a researcher-developed questionnaire among 248 farmers from the rural areas of Ilam in June 2013. The items of the questionnaire were based on the protection motivation theory, and covered components included perceived vulnerability, perceived severity, and rewards. Result: We found a generally lower perceived vulnerability and severity and higher rewards among the farmers; 14.5 and 30.6 % of the farmers displayed higher perceived vulne
Dehghani Leila; Khanjani Narges; Bahrampour Abbas
Volume 15, Issue 4 , 2012, , Pages 111-116
Abstract
Background: Skin cancers are the most common human cancers.The most common skin cancers are basal cell carcinoma, squamouscell carcinoma and malignant melanoma. Different factors areinvolved in development of skin cancers; the most notable oneis exposure to ultraviolet radiation. In this study, the incidenceof ...
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Background: Skin cancers are the most common human cancers.The most common skin cancers are basal cell carcinoma, squamouscell carcinoma and malignant melanoma. Different factors areinvolved in development of skin cancers; the most notable oneis exposure to ultraviolet radiation. In this study, the incidenceof skin cancer was determined in Kerman province where islocated in the desert region of Iran with ample sunlight, duringa 5–year period.Method: All registered cases of skin cancers between March2005 and March 2010 were retrieved from the Kerman ProvinceCancer Registry. For each patient, data about age, gender,location, pathologic type of cancer and site of skin involvement,were obtained. Incidence rates according to the age, sex and thelocation of the lesions were calculated. Trend analysis was donefor the next 10 years.Result: During these 5 years, 1250 cases of skin cancer wererecorded. The incidence in men was 1.2 times higher than women.The highest incidence was seen in individulas older than 80 yearsof age. Fifty percent of all skin cancers were located on the face.The highest incidence was observed in the city of Kerman withan annual incidence of 12.6 in 100,000. Trend analysis showedthat the incidence of skin cancer in Kerman province would reach23 in 100 000 people in 2019, which is 2.3 times higher than theincidence rate in 2009.Conclusion: Skin cancer is a public health concern in Kermanprovince in Iran. Considering the desert climate and the intensity ofsunlight in most seasons, it is necessary to plan scientific practicalinterventions to prevent skin cancer and reduce its incidence..
Mohammad Taghi Noorbala
Volume 10, Issue 1 , 2007, , Pages 13-19
Abstract
Background and aim: Skin cancer is the most common human cancer. Ultraviolet radiation is now recognized as the most important risk factor for skin cancer development. Light skin colored individuals that spend more time outdoors in day are more susceptible to disease. In this study skin cancer situation ...
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Background and aim: Skin cancer is the most common human cancer. Ultraviolet radiation is now recognized as the most important risk factor for skin cancer development. Light skin colored individuals that spend more time outdoors in day are more susceptible to disease. In this study skin cancer situation in Yazd (located in a hot, dry and desert area) was reviewed.Materials and methods: In this existing data study all recorded cancers in pathology laboratory of University of Medical Sciences of Yazd between 1988-1996 were reviewed and skin cancers were studied.Results: 2360 patients with cancer were recorded. Skin cancer was the most common with 646 cases (27.3%). Bladder, stomach, breast and esophagus cancers were the other most common cancers. Among skin cancers basal cell carcinoma was the most common (77%). Other skin cancers included squamous cell carcinoma (17.8%), malignant melanoma (2.8%) and miscellaneous tumors (2.4%). Skin cancers were 1.5 times more common in males, and the majority of patients were in seventh and eighth decades of life. 91.5% of skin cancers were on face, head and neck.Conclusion: Skin cancer was the most common human cancer in Yazd. Considering skin type and intensity of sun in this area, more intensive preventive programs must be implemented.
M Barzegari; Z Safaei Naraghi; M Akhyani; AH Ehsani; R Mahmoud Robati; S Bagheri Nejad
Volume 9, Issue 2 , 2006, , Pages 159-164
Abstract
Background and aim:Basal cell carcinoma (BCC) is the most common cancer in whites. The most important risk factor for developing BCC is solar ultraviolet (UV) irradiation. As the weather in most parts of Iran is mostly sunny, BCC is common. This study was performed to evaluate changes in the frequency ...
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Background and aim:Basal cell carcinoma (BCC) is the most common cancer in whites. The most important risk factor for developing BCC is solar ultraviolet (UV) irradiation. As the weather in most parts of Iran is mostly sunny, BCC is common. This study was performed to evaluate changes in the frequency of BCC in 1368-69 and 1378-79.Materials and Methods: This descriptive and retrospective study was performed as an existing data study and all files in department of pathology in Razi Hospital from 1368-69 and 1378-79 were assessed with regards of BCC frequency, patient age and gender as well as history of radiation and the collected data were compared.Results: A total of 1503 BCCs were studied, 507 were from 1368-69 and 996 from 1378-79 period. In the years 1368-69, relative frequency of BCC was 11.1%. On the other hand in years 1378-79 relative frequency of BCC was increased to 15.2%, which was not associated with gender. BCC occurance showed a significant decrease in 20-30-year age group and a significant increase in over 60 years age group. Among histologic subtypes, nodular form showed an increase, which was statistically significant on face region (P<0.005), but was not linked to patient gender. In male patients significant decrease of BCC frequency on face and increase on head and neck areas was observed, but there was not any significant change in tumor location in female patients.Conclusion:During a 10-year period the frequency of BCC has increased significantly requiring more attention to develop educational programs regarding prevention, diagnosis and early treatment.
E Yousefi
Volume 8, suppl , 2005, , Pages 38-41
Abstract
Basal cell carcinoma (BCC) is a malignant tumor of epithelial cells that is composed of cells similar to those in the basal area of the epidermis and its appendages. Ninety- five percent of individuals with BCC are between 40 and 79 years old. It rarely occurs in younger individuals. Herein, a 20- year- ...
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Basal cell carcinoma (BCC) is a malignant tumor of epithelial cells that is composed of cells similar to those in the basal area of the epidermis and its appendages. Ninety- five percent of individuals with BCC are between 40 and 79 years old. It rarely occurs in younger individuals. Herein, a 20- year- old woman with type III skin, who had a BCC on her chin is presented. Since the clinical features and age of onset of this lesion were not typical for BCC , correct diagnosis was confirmed by histological examination.
MA Mapar; P Bakhtiari Nia; F Zia
Volume 3, Issue 3 , 2000, , Pages 23-28
Abstract
Background: Basal cell carcinoma (BCC) is the most common skin cancer in humans showing various clinical and histological forms. Objective: The aim of this study was to evaluate the age, sex, location, histological subtypes of BCC cases in Ahwaz and to compare it with other skin cancers specially squamous ...
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Background: Basal cell carcinoma (BCC) is the most common skin cancer in humans showing various clinical and histological forms. Objective: The aim of this study was to evaluate the age, sex, location, histological subtypes of BCC cases in Ahwaz and to compare it with other skin cancers specially squamous cell carcinoma. Patients and Methods: A descriptive, retrospective study was done using files of Pathology Department of Imam Khomeini Hospital in Ahwaz. All files from 1366 to 1376 were searched and the files of patients with skin cancers were evaluated. Results: 1271 of about 70000 specimens were diagnosed as skin cancer. 896 of them (70.50%) were BCC. The incidence of BCC was equal in women and men. The mean age was 60 years. An interesting finding was the difference in the mean age of patients in the first 2 years (57.58 years) and last 2 years of study (63.27 years). Eighty percent of patients were in the age range of 40-80 years. The most frequent locations of the lesions were nose, cheeks, forehead and eyelids. The incidence of SCC (294 cases) was almost 1/3 of BCC. Conclusion: The most common skin cancer in Ahwaz is BCC. The frequency is equal in both sexes. The mean age is 60 years and is increasing with time.