Yalda Nahidi; Naser Tayyebi Meibodi; Pooran Layegh; Sara Sharifi
Abstract
Background: Lichen planus (LP) is a chronic inflammatory disease involving the skin, mucous membranes and appendages. Like other chronic inflammatory diseases, it may be associated with metabolic disorders and dyslipidemia. Due to the discrepancies in the results of previous studies and lack of a similar ...
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Background: Lichen planus (LP) is a chronic inflammatory disease involving the skin, mucous membranes and appendages. Like other chronic inflammatory diseases, it may be associated with metabolic disorders and dyslipidemia. Due to the discrepancies in the results of previous studies and lack of a similar study on an Iranian population, we decided to investigate and compare the serum lipid levels of LP patients and normal healthy subjects.Methods: In this case-control study, 71 patients with lichen planus confirmed by clinical and pathological examination who referred to dermatology clinic were recruited; further included were 71 subjects selected from attendants without any skin diseases matched for age, gender and BMI.with patients; the well-being of the healthy subjects was confirmed by laboratory tests, physical examination and medical history..After filling the questionnaire, triglyceride, cholesterol, HDL and LDL levels were measured for patients and healthy subjects..The collected data were then analyzed.Results: Mean age of patients in the case group was 40.63 ± 11.41 years, 50.6% of whom were men, while 49.4% were women. Cholesterol, triglyceride and LDL levels in patients were significantly higher than the control group; it was only regarding HDL levels that no significant difference was observed between the two groups. HDL and triglyceride levels were significantly higher in patients with generalized disease. There was a recognizable correlation between elevated levels of LDL and cholesterol and disease duration.Conclusions: In this study, a disrupted lipid profile was observed in LP patients, which can be associated with disease severity. This study proposes measuring lipid serum levels prior to commencing the treatment in all known cases of lichen planus so as to preclude cardiovascular diseases if there is a problem with the lipid profile.
Yaghoobi Reza; Pazyar Nader; Kalantari Hooman
Volume 20, Issue 1 , 2017, , Pages 11-14
Abstract
Background: Lichen planus (LP) is a chronic inflammatory skin condition which leads to changes in lipid metabolism. It may cause chronic atherosclerosis and metabolic syndrome. Theobjective of this study is to compare lipid levels of patients with LP to healthy controls. Methods: This case-control study ...
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Background: Lichen planus (LP) is a chronic inflammatory skin condition which leads to changes in lipid metabolism. It may cause chronic atherosclerosis and metabolic syndrome. Theobjective of this study is to compare lipid levels of patients with LP to healthy controls. Methods: This case-control study recruited 100 total participants, 50 (25 male and 25 female) patients with LP and 50 healthy controls admitted to the Dermatology Clinic of Imam Hospital, Ahvaz, Iran. Serum triglyceride, total cholesterol, HDL cholesterol, and LDL cholesterol levels were measured in samples drawn after a 12-hour fasting period. Results: Patients with LP had significantly higher triglycerides (147.7 vs. 118.4 mg/dl, P<0.05), total cholesterol (188 vs. 173 mg/ dl, P<0.05), LDL (122 vs. 106 mg/dl, P<0.05), and lower HDL (49 vs. 57 mg/dl, P<0.05) levels compared to controls. Conclusion: This study showed an association between LP and dyslipidemia. Screening of serum lipids in patients with LP might be valuable to prevent cardiovascular diseases.
S Nassiri; S Taghavian Pour; A Sadiqha
Volume 8, Issue 4 , 2005, , Pages 266-271
Abstract
Background an objective: Several studies have indicated that vertex type androgenetic alopecia have a higher-than-normal risk for coronary heart disease but few studies focused on lipid profiles which are important in the pathogenesis of coronary heart disease. This study was designed to investigate ...
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Background an objective: Several studies have indicated that vertex type androgenetic alopecia have a higher-than-normal risk for coronary heart disease but few studies focused on lipid profiles which are important in the pathogenesis of coronary heart disease. This study was designed to investigate the relation between vertex type androgenetic alopecia (Grade III and higher according to Hamilton-Norwood) and hyperlipidemia.Materials and Methods: In this case-control study, lipid parameters (Total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, total cholesterol/HDL cholesterol ratio) of 50 men with vertex type androgenetic alopecia (Study group) were compared with 50 men with normal hair status (Control group). Study group matched according to the age, BMI and habit of smoking with control group.Results: Study group had a higher triglyceride and lower HDL cholesterol levels than control group. Total cholesterol/HDL cholesterol ratio was significantly higher in study group (P<0.05).Conclusion: Vertex type androgenetic alopecia could be a clinical marker of hyperlipidemia and dermatologists should investigate lipid profile in these patients.