Seirafi Hassan; Farahani Farzaneh; Farnaghi Farshad; Ehsani Amirhooshang; Hashemi Pantea; Farahani Amir
Volume 11, Issue 1 , 2008, , Pages 1-6
Abstract
Background: Narrow band Ultraviolet B (NBUVB) has been used successfully for the treatment of vitiligo. Recently, topical calcipotriol has also been used as immunotherapy or as a part of combination therapies. The aim of this study was to compare the clinical efficacy and safety of NBUVB and NBUVB plus ...
Read More
Background: Narrow band Ultraviolet B (NBUVB) has been used successfully for the treatment of vitiligo. Recently, topical calcipotriol has also been used as immunotherapy or as a part of combination therapies. The aim of this study was to compare the clinical efficacy and safety of NBUVB and NBUVB plus topical calcipotriol in the treatment of generalized vitiligo.Methods: NBUVB phototherapy was given to 26 patients with generalized, symmetrical vitiligo three times weekly. Topical calcipotriol cream was only applied on the lesions located on one side of the body. Treatment was continued until cosmetically acceptable repigmentation occurred, but total cumulative dose of NBUVB did not increase from the mean of 113.4 ± 47.0 j/cm. The efficacy of treatment was evaluated by visually scoring the percentage of regimentation of the lesions at 12-session intervals by an investigator unaware of the side of calcipotriol application. Results: The mean daily dose of NBUVB was 1.4 ± 0.6 j/cm. The median number of exposure for initial regimentation was 26.5 (range 14-38) on the side of combination therapy with calcipotriol and 25.3 (range 20-40) on the other side. After 24 sessions of treatment, 14 patients (53.9%) showed minimal to moderate improvement on the calcipotriol treated side as compared to 21 patients ( 80.8 %) on the other side. After 60 sessions of treatment, 16 patients (16.5 %) showed moderate to marked regimentation on the side of combination therapy with calcipotriol as compared to 19 patients (73 %) on the other side.Conclusion: These findings indicate that concurrent use of topical calcipotriol does not enhance the efficacy of NBUVB in the treatment of vitiligo.
Esfandiarpour Iraj; Yavari Hossein
Volume 10, Issue 2 , 2007, , Pages 119-124
Abstract
Background and aim: Vitiligo is an acquired idiopathic hypomelanotic disease. The purpose of this study was to review clinical characteristics of vitiligo and their significance in the progression of vitiligo.Materials and methods: Eight hundreds and sixteen cases of vitiligo were studied from February ...
Read More
Background and aim: Vitiligo is an acquired idiopathic hypomelanotic disease. The purpose of this study was to review clinical characteristics of vitiligo and their significance in the progression of vitiligo.Materials and methods: Eight hundreds and sixteen cases of vitiligo were studied from February 2005 to October 2006. All of the patients were referred to dermatology clinics in Kerman city. Questionnaires were completed regarding progression, sex, family history, clinical type, age at onset,site of lesions, duration of disease, Koebner phenomenon, leukotrichia, and mucosal involvement.Results: Six hundreds and seven patients (74.39%) showed progression of disease and 209 patients (25.61%) did not show progression. There was no significant difference between the two groups in regard to sex, age at onset, leukotrichia, positive family history or longer duration; however, in patients with non-segmental clinical type, Koebner phenomenon and mucous membrane involvement indicated more progressive course of vitiligo (p<0.05).Conclusion: The progression or prognosis of vitiligo may be related to clinical characteristics such as clinical type, Koebner phenomenon, and mucous membrance involvement.
Z Parsa Yekta; L Barim Nejad; AR Nikbakht Nasr Abadi
Volume 9, Issue 1 , 2006, , Pages 54-63
M Bani Hashemi; Sh Izadi
Volume 7, Issue 2 , 2004, , Pages 84-87
Abstract
Background: There is controversy about the relationship between vitiligo and thyroid dysfunction. Objective: To evaluate the relationship between vitiligo and thyroid disorders. Patients and Methods: This was a case-control study carried out on individuals with vitiligo in 2004 in Zahedan, that had it ...
Read More
Background: There is controversy about the relationship between vitiligo and thyroid dysfunction. Objective: To evaluate the relationship between vitiligo and thyroid disorders. Patients and Methods: This was a case-control study carried out on individuals with vitiligo in 2004 in Zahedan, that had it for at least 6 months as cases and individuals without vitiligo considered as the control group (Age and sex were matched with case group). T3, T4, TSH, T3RU in both groups were assessed and FTI was calculated. Then hypo-, hyper- and euthyroid states were determined based on FTI and T3 level (For T3 hyperthyroidism) and data were analyzed by conditional logistic regression. Results: Each study group consisted of 50 individual, 52% female and 48% male. In the patient group, 16% had thyroid dysfunction, 14% of which had hyperthyroidism and 2% hypothyroidism. In control group, 4% had thyroid dysfunction, 2% of which had hyperthyroidism and 2% hypothyroidism. In case group only one patient had signs and symptoms of hyperthyroidism but in control group none had clinical symptoms. With statistical analysis was done odds ratio=7 (P<0.05) and the difference was significant. Conclusion: Vitiligo patients should be evaluated for thyroid dysfunctions to prevent complications of thyroid disease.
F Pezeshk Pour; MJ Yazdan Panah; AR Taheri; H Assadi
Volume 6, Issue 4 , 2003, , Pages 28-30
Abstract
Background: Vitiligo is a common autoimmune skin disease that may occur in association with other autoimmune disorders especially those of the endocrine system. Diabetes mellitus is a common endocrine disease associated with vitiligo. Objective: To study the association of vitiligo and diabetes mellitus. ...
Read More
Background: Vitiligo is a common autoimmune skin disease that may occur in association with other autoimmune disorders especially those of the endocrine system. Diabetes mellitus is a common endocrine disease associated with vitiligo. Objective: To study the association of vitiligo and diabetes mellitus. Patients and Methods: In this descriptive cross-sectional study, 750 diabetic patients referred to Mashhad Diabetes Center were studied in Shahrivar 1380. Results: Thirty-two (4.3%) of these patients suffered from vitiligo that mostly was of generalized type. The face was the most common site of involvement. Twenty-two patients (68.7%) were female and 10 patients (31.3%) were male. Five percent of female and 3.3% of male diabetics suffered from vitiligo. 4.2% of NIDDM diabetics and 4.7% of IDDM diabetics suffered from vitiligo. Conclusion: Vitiligo was more common in NIDDM than IDDM because of the higher prevalence of NIDDM, but the association of vitiligo with IDDM was stronger. Vitiligo was more common in female than male diabetics.
I Esfandiar Pour; P Afshar Zadeh
Volume 6, Issue 3 , 2003, , Pages 13-18
Abstract
Background: Some skin diseases cause severe stress in patients and relieving these stresses greatly helps to treat the underlying disease and to prevent the recrudescence of it. Objectives: To determine the frequency of depression in patients suffering from vitiligo. Patients and Methods: 120 patients ...
Read More
Background: Some skin diseases cause severe stress in patients and relieving these stresses greatly helps to treat the underlying disease and to prevent the recrudescence of it. Objectives: To determine the frequency of depression in patients suffering from vitiligo. Patients and Methods: 120 patients with a clinical diagnosis of vitiligo referred to dermatologic clinics in Kerman from 1380 to 1381 were studied. The impression of vitiligo was made according to clinical interview and physical examination. After filling the questionnaire the patients were referred to psychiatric clinic to fill in the Hamilton questionnaire. Results: 120 patients included 74 women (61.6%) and 46 men (38.4%) with mean age of 23±13 years. 30.83% (37 patients) had no depressive disorder, 38.34% (46 patients) had depressed mood and 30.83% (37 patients) had major depressive disorder. From 37 patients with major depressive disorder, 27 patients (73%) were female and 10 patients (27%) were male (P<0.001). Conclusion: Any clinical intervention that reduces the extension and visibility of depigmentation will have psychologic benefit. It may be important to recognize and deal with the social and psychologic consequences of the disease.
J Golchai; A Ramazanpour
Volume 5, Issue 4 , 2002, , Pages 44-47
Abstract
Although lichen planus and vitiligo are common skin disorders, their association with two other uncommon diseases, i.e. lichen sclerosus et atrophicus and disseminated superficial actinic porokeratosis, seems to be a very rare occurrence. We report herein a 70-year-old man who developed all of these ...
Read More
Although lichen planus and vitiligo are common skin disorders, their association with two other uncommon diseases, i.e. lichen sclerosus et atrophicus and disseminated superficial actinic porokeratosis, seems to be a very rare occurrence. We report herein a 70-year-old man who developed all of these four skin disorders simultaneously.
SM Alavian; A Shokoohi
Volume 5, Issue 3 , 2002, , Pages 45-49
Abstract
α-Interferon is an antiviral agent used in treatment of chronic hepatitis B. Triggering of the underlying autoimmune disease or exacerbation of pre-existing auto immune disease is documented with α-interferon, but there are few reports about occurrence of autoimmune disorders such as systemic ...
Read More
α-Interferon is an antiviral agent used in treatment of chronic hepatitis B. Triggering of the underlying autoimmune disease or exacerbation of pre-existing auto immune disease is documented with α-interferon, but there are few reports about occurrence of autoimmune disorders such as systemic lupus erythematosus, Vitiligo, hypo and hyperthyroidism after administration of α-interferon in the literature. We report here in two cases of chronic hepatitis B treated with a-interferon, who developed Vitiliginous lesions. These lesions disappeared within 3 to 6 months after discontinuing α-interferon therapy. Until now, the occurrence of vitiligo after administration of α-interferon in chronic hepatitis B has not been reported.
M Valikhani; L Vosooghian
Volume 4, Issue 2 , 2001, , Pages 13-16
Abstract
Background: Vitiligo is a common disease. Its etiology is not known, but 30% of patients have a positive family history. Studies have been done on the influence of ABO and Rh blood groups on susceptibility to some diseases. Objective: The purpose of this case-control study was to evaluate the association ...
Read More
Background: Vitiligo is a common disease. Its etiology is not known, but 30% of patients have a positive family history. Studies have been done on the influence of ABO and Rh blood groups on susceptibility to some diseases. Objective: The purpose of this case-control study was to evaluate the association of ABO and Rh blood groups with vitiligo. Patients and Methods: This study was performed on 200 vitiligo patients referred to skin clinics of Razi Hospital. The blood groups of patients were determined and compared with 200 control subjects and the general blood group distribution in Iran (Published by Iran Blood Transfer Organization). Results: There was no specific association established between vitiligo and ABO and Rh blood groups. Blood group B showed the most difference but still it was not significant (P>0.05). Conclusion: There was no association with the ABO and Rh blood group in vitiligo patients.
S Family
Volume 4, Issue 2 , 2001, , Pages 17-20
Abstract
Background: Vitiligo is a pigmentary disorder of the skin, which has been reported in association with thyroid disorders. Objective: The aim of this study was to assess thyroid disorders in vitiligo patients. Patients and Methods: In this case-control study, thyroid function tests were evaluated in seventy ...
Read More
Background: Vitiligo is a pigmentary disorder of the skin, which has been reported in association with thyroid disorders. Objective: The aim of this study was to assess thyroid disorders in vitiligo patients. Patients and Methods: In this case-control study, thyroid function tests were evaluated in seventy patients with vitiligo and compared with a control group. Results: Nine of seventy patients with vitiligo (12.9%) and one of controls (1.4%) had abnormal thyroid function tests. Conclusion: Thyroid disorders are more common in vitiligo.
A Momeni; MR Kharazi; M Amin Javaheri
Volume 3, Issue 3 , 2000, , Pages 29-34
Abstract
Background: Vitiligo is a common skin disease that clinically presents as depigmented macules due to destruction of melanocytes. Although the cause is unknown, various theories such as autoimmune, autodestruct and neural hypotheses have been proposed. Objective: The objective of this study was to evaluate ...
Read More
Background: Vitiligo is a common skin disease that clinically presents as depigmented macules due to destruction of melanocytes. Although the cause is unknown, various theories such as autoimmune, autodestruct and neural hypotheses have been proposed. Objective: The objective of this study was to evaluate clinical picture of vitiligo in Isfahan, Iran. Patients and Methods: In a descriptive study, all vitiligo patients referred to a private skin clinic in Isfahan during one year (1376) were evaluated. Results: 458 of a total of 6540 patients had vitiligo (7.0%). Most of the patients were female (61.1%). The mean age of disease onset was 20.83 years. The site of onset of lesions was extremities in 41.1%, head and neck in 37.80%, trunk in 16.24% and genitalia in 5.49% of patients. 72% of the patients who had lesions of the face, responded well to topical steroids. Conclusion: Vitiligo is a common skin disease in Isfahan and a large study is needed to show the prevalence of the disease in Iran.
