Karen Christelle; Maryam Mohd Zulkifli; Nani Draman
Abstract
Pemphigoid gestationis is an unusual autoimmune dermatosis of pregnancy, and recurrences may occur in consequent pregnancies. This dermatosis begins with intense itching, which progresses to papules and annular plaques and, consequently, vesicles and tense bullae. These lesions typically arise from the ...
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Pemphigoid gestationis is an unusual autoimmune dermatosis of pregnancy, and recurrences may occur in consequent pregnancies. This dermatosis begins with intense itching, which progresses to papules and annular plaques and, consequently, vesicles and tense bullae. These lesions typically arise from the umbilical region then spread centrifugally to the abdomen, thighs, palms, and soles. Diagnosis is based on clinical examination and immunohistopathologic studies. Here, we report the case of a 29-year-old women who developed recurrent pemphigoid gestationis in her second pregnancy and the postpartum period in 2020. The condition initially manifested during her first pregnancy in 2014. She was successfully treated with oral prednisolone and the local application of betamethasone cream. Pruritic skin lesions are a common complaint among pregnant women. Clinicians should be aware of autoimmune dermatosis of pregnancy, its fetomaternal and neonatal complications, and its possibility of recurrence in subsequent pregnancies.
Siddalingappa Karjigi; Murthy Sambasiviah Chidambara; Herakal Kallappa; Deepika Madagondanahalli
Volume 20, Issue 2 , 2017, , Pages 50-53
Abstract
Background: Chronic urticaria (CU) is a common skin disorder that accounts for 15%-20% of dermatological cases. There is growing evidence that some cases of chronic idiopathic urticarial (CIU) are associated with various autoimmune diseases, including thyroid autoimmunity. This study aims to identify ...
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Background: Chronic urticaria (CU) is a common skin disorder that accounts for 15%-20% of dermatological cases. There is growing evidence that some cases of chronic idiopathic urticarial (CIU) are associated with various autoimmune diseases, including thyroid autoimmunity. This study aims to identify the thyroidprofile, including thyroid autoantibodies, in patients with CU.Methods: This case-control study included 100 patients with CU and 100 controls without urticaria. Males and females (age range: 20-40 years) who attended the Navodaya Medical College Hospital and Research centre were included. Participants underwent laboratory investigations that consisted of a complete blood count(CBC) thyroid autoantibodies, and other relevant investigations. Results: Patients in the CU group had a male to female ratio of 1:2.1 and a mean age of 31.2 years. The control group had a male to female ratio of 1:1 and a mean age of 35 years. Antimicrosomal antibodies (AMA) were present in 14 (14%) patients, 13 females and 1 male. There were no autoantibodies in any of the control group participants. Among these 14 patients, 5 (35.71%) had elevated serum thyroid stimulating hormone (TSH) and one had coexistent anti-thyroglobulin antibodies. Other associated diseases included diabetes mellitus, human immunodeficiency virus (HIV), and hepatitis B surface antigen (HBsAg) in onepatient each.Conclusion: Thyroid autoantibodies may play a role in persistent CU. Screening patients with persistent CU for thyroid functions, including thyroid autoantibodies, may help with proper management.
Yazdanfar Ameneh; Hashemi Banafsheh
Volume 13, Issue 2 , 2010, , Pages 51-53
Abstract
Introduction: Melasma is a common acquired hypermelanosis seen mainly in women which occurs on the sun-exposed skin of the face. The exact cause of melasma is unknown. The majority of the cases are attributed to pregnancy, combined oral contraceptive pills, genetic factors, sun exposure, use of cosmetic ...
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Introduction: Melasma is a common acquired hypermelanosis seen mainly in women which occurs on the sun-exposed skin of the face. The exact cause of melasma is unknown. The majority of the cases are attributed to pregnancy, combined oral contraceptive pills, genetic factors, sun exposure, use of cosmetic products, thyroid disorders and anti-convulsant drugs. This study was performed to evaluate the relationship between thyroid autoimmunity and melasma. Methods: In this case-control study, 45 females with melasma who were 20-50 years old and were referred to our clinic and 45 age-matched healthy females with no history of melasma as the control group were evaluated. The skin and thyroid of all of them were examined carefully and their sera were collected and evaluated for thyroid function tests and anti thyroid peroxidase (anti TPO). Data was also statistically analyzed. Results: Serum anti TPO level was higher than normal in %24.4 of the patients and %6.7 of the controls. The difference between two groups was statistically significant (P=0.019). Serum T3 level was higher than normal in %75.6 of the patients and %48.9 of the controls. The difference between the two groups was also statistically significant (P=0.008). Mean serum anti TPO, T3 and TSH were higher in the case group than the control group, but the difference was not statistically significant. Conclusion: A possible relationship might be observed between thyroid autoimmunity and melasma.