Nadia Abdalhafid Elsherif; Salwa Abdalsalm El-Dibany; Azza SH Greiw
Abstract
Background: Alopecia areata (AA) is non-scarring hair loss. Its etiopathology is not fully known, most evidence considered AA an immunologically mediated disease. To compare serum levels of total immunoglobulin E (IgE) between AA patients and healthy subjects, and to assess whether AA is associated with ...
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Background: Alopecia areata (AA) is non-scarring hair loss. Its etiopathology is not fully known, most evidence considered AA an immunologically mediated disease. To compare serum levels of total immunoglobulin E (IgE) between AA patients and healthy subjects, and to assess whether AA is associated with atopy.
Methods: 50 AA patients and 50 healthy subjects were included in this study. Presence of atopy was elicited by detailed family and/ or personal history of atopy. Clinically patients were divided into 2 groups: patients with single patch of AA (alopecia unilocularis, AU), or with multiple patches (alopecia multilocularis, AM). Serum levels of IgE were measured in both groups.
Results: Serum levels of total IgE were significantly higher in patients than in controls (178 ± 154 ku/l vs. 118 ± 57 ku/l; P < 0.05). Evidence of atopy was present in 48% of AA patients compare to 18% of control subjects (P < 0.05). Patients with disease duration more than one year had significantly higher serum IgE levels (P < 0.05), and patients with AM had significantly higher serum IgE levels than patients with AU (267 ± 189 ku/l vs. 102 ± 32.3 ku/l; P < 0.05). Mean value of serum IgE did not vary significantly with patient’s age at onset, gender, history of atopy or family history of AA. Atopy was significantly associated with AM.
Conclusion: Total serum IgE is elevated in AA patients with significant association with severe and chronic disease irrespective of the presence of atopy. Atopic diseases were more frequent in AA patients with severe clinical presentation.
Omidian Mohammad; Omidian Ehsan
Volume 12, Issue 3 , 2009, , Pages 90-92
Abstract
Background: The etiology of urticaria is recognized only in a minority of cases. Allergies to a wide variety of agents have been suspected, as well as hyper reactivity to food additives or drugs. Recently, autoimmune reaction to immunoglobulin E (IgE) and later to high-affinity IgE receptors on mast ...
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Background: The etiology of urticaria is recognized only in a minority of cases. Allergies to a wide variety of agents have been suspected, as well as hyper reactivity to food additives or drugs. Recently, autoimmune reaction to immunoglobulin E (IgE) and later to high-affinity IgE receptors on mast cells has been reported. The aim of this study was to show elevated serum IgE levels in the patients with chronic idiopathic urticaria (CIU) so that the underlying disease and the cause of CIU may be atopic condition or an occult disease with raised serum IgE. Method: Altogether, 57 patients (30 women and 27 men, with an age range from 14 to 75 years ; mean age of 35.86 years), who suffered from chronic urticaria with a duration of 3 months to 8 years were included in this study and serum IgE level was assessed. Result: Thirty three patients had elevated serum IgE levels. The range of IgE levels were 114-3280 U (geometric mean greater than 100 ku/l) and mean IgE level was 411.39 U. Conclusion: Although the causes of CIU are often not clear, at least one causes of CIU may be atopy or other diseases that may be hidden and show elevated serum IgE. The patients present with CIU along with elevated serum IgE, should be investigated for atopy or other diseases that may be associated with elevated serum IgE.
Farajzadeh Saeedeh; Zandi Soodabeh; Vares Behrooz; Sharifzadeh Mahdiyeh; Fekri Ali-Reza
Volume 11, Issue 1 , 2008, , Pages 21-24
Abstract
Background: Atopic dermatitis is the most common chronic inflammatory dermatitis, due to immunological disorders. Patients with atopic dermatitis are prone to infectious diseases including bacterial infections. On the other hand, atopy may be protective against helminthes parasites. The objective of ...
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Background: Atopic dermatitis is the most common chronic inflammatory dermatitis, due to immunological disorders. Patients with atopic dermatitis are prone to infectious diseases including bacterial infections. On the other hand, atopy may be protective against helminthes parasites. The objective of this study was to compare the frequency and clinical presentations of cutaneous leishmaniasis in atopic dermatitis patients with the control group in an outpatient clinic in Kerman.Methods: This was a case – control study done on 459 patients with atopic dermatitis, who were diagnosed based on Hanifin & Rajka criteria and 400 healthy subjects without immunosuppression as our control group. The frequency of leishmaniasis was investigated in both groups according to age, gender and residential area.Results: Among 459 atopic dermatitis patients, 232 were female and 227 were male. Control group consisted of 232 males and 168 females. The mean age of the atopic dermatitis patients and the controls was 9.2 and 13.3 years, respectively (p0.05%). There was no statistically significant difference in clinical presentations of leishmaniasis between two groups.Conclusion: In this study there was no significant relationship between leishmaniasis and atopic dermatitis. This finding can be due to the small sample size or the difference between case and control groups regarding age.