Ehsani Amir Houshang; Noormohammadpour Pedram; Nasiri Nafiseh; Faraz Parastoo Tavasoli; Goodarzi Azadeh
Volume 19, Issue 2 , 2016, , Pages 45-49
Abstract
Background: Approximately 0.77% to 2% of cutaneous ulcers and post-burn scars will develop malignant degeneration. When squamous cell carcinoma (SCC) emerges in a chronic scar or ulcer, it often is referred to as Marjolin’s ulcer (MU). Methods: This cross-sectional study assessed demographic information ...
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Background: Approximately 0.77% to 2% of cutaneous ulcers and post-burn scars will develop malignant degeneration. When squamous cell carcinoma (SCC) emerges in a chronic scar or ulcer, it often is referred to as Marjolin’s ulcer (MU). Methods: This cross-sectional study assessed demographic information and pathological features of MU in Razi Hospital during 2009 to 2014. We reviewed 5150 chronic scar/ulcer cases and found 30 MU cases. Results: Patients had an average age of 59.2±19.9 years. Most cases were males Among 30 cases of MU, well-differential SCC accounted for 43.3% of cases. Moderately-differentiated SCC comprised 13.3% of cases, whereas there was invasive SCC in 10% of MUs. Only 3.3% of patients showed poorly-differentiated SCC and 9 (30%) had undifferentiated SCC. The average latency between burn and malignancy was 32.4±18.5 years In the majority (90%) of cases, the initial injury was a burn. The lower and upper limbs comprised 53.3% and 26.7% of cases, respectively. There was one case with a history of melanoma. Among the 4 measured concurrent risk factors for malignancy, sun exposure was the most prevalent. Conclusion: Since there is a high possibility of SCC formation in burn lesions and other identical lesions, rapid follow-up and appropriate treatment in acute burn lesions is necessary.
Iffat Hassan; Peerzada Sajad; Syed Mubashir
Volume 17, Issue 3 , 2014, , Pages 101-103
Abstract
Background: Bowen’s disease is a form of intraepidermal squamous cell carcinoma (SCC) characterised by a persistent, non-elevated, red, scaly or crusted plaque with a small potentialfor invasive malignancy. Most cases of typical Bowen’s disease in the white population are found ...
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Background: Bowen’s disease is a form of intraepidermal squamous cell carcinoma (SCC) characterised by a persistent, non-elevated, red, scaly or crusted plaque with a small potentialfor invasive malignancy. Most cases of typical Bowen’s disease in the white population are found on the lower legs of the elderly women. However, in this part of the world, i.e. Kashmir, the mostcommon site is thighs followed by the lower abdomen. A range of treatment options are available for it including cryotherapy, curettage and cautery, photodynamic therapy, laser destruction,surgical excision, 5-fluorouracil cream, imiquimod cream, and radiotherapy. The aim of this study was to evaluate the efficacy of surgical excision in Bowen’s disease.Method: All the patients with biopsy proven Bowen’s disease were included for the study. A detailedhistory was taken for each patient including the history of medical treatment for Bowen’s disease. Wide surgical excision (including either fusiform excision, W-plasty, or Z-plasty) was performed in each patient and the patients were then followed up for any recurrence. No sign of renewed disease activity at 6 months follow-up was taken as cure. All patients are intended to be followed up for 5 years.Result: Ten out of 12 patients reported the use of topical imiquimod cream but complained of the progression of lesions. Surgical excision was performed in 12 patients. All the patients are currently under regular follow-up. Except for secondary infection and wound dehiscence in one patient, all the patients are in good condition with no signs of recurrence.Conclusion: Although it was a preliminary study, we recommend surgical excision in treatment of Bowen’s disease due to low recurrence rate.
Mubashir Syed; Anwar Parvaiz; Hassan Iffat; Arif Tasleem
Volume 17, Issue 2 , 2014, , Pages 68-71
Abstract
Squamous cell carcinoma (SCC) of the skin is one of the mostcommon non melanoma skin cancers (NMSC), along withbasal cell carcinoma (BCC). Besides ultraviolet radiation,exposure to industrial agents, ionizing radiation, and areas ofchronic inflammation are associated with the development ofSCC. Squamous ...
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Squamous cell carcinoma (SCC) of the skin is one of the mostcommon non melanoma skin cancers (NMSC), along withbasal cell carcinoma (BCC). Besides ultraviolet radiation,exposure to industrial agents, ionizing radiation, and areas ofchronic inflammation are associated with the development ofSCC. Squamous cell carcinoma may also be associated withforeign bodies. We report a rare case of cutaneous SCC in anelderly Kashmiri female, which was developed subsequent to asubcutaneous non metallic foreign body and was successfullyexcised with negative margins and transposition flap closure.
Maleki Masoud; Naghibi Masih; Sabouri-Rad Sara; Sardar Akram
Volume 17, Issue 1 , 2014, , Pages 18-21
Abstract
Background: The higher frequency of malignant skin tumors is of great significance in renal transplant recipients (RTRs) who should receive immunosuppressive therapy for a long time. This study was designed to determine the frequency of malignant skin tumors in RTRs in Imam Reza Hospital, Mashhad, Iran, ...
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Background: The higher frequency of malignant skin tumors is of great significance in renal transplant recipients (RTRs) who should receive immunosuppressive therapy for a long time. This study was designed to determine the frequency of malignant skin tumors in RTRs in Imam Reza Hospital, Mashhad, Iran, in 2001-2002.Method: This descriptive study was performed on 322 recipients who were examined by a dermatologist for malignant skin tumors in the renal transplant unit. A questionnaire containing a detailed history of age, sex, and site of the lesion, time of transplantation, occupation, and time of cancer development was completed for patients with a biopsy proven skin cancer.Result: Nine patients (2.8%) had malignant skin tumors. Five patients (55.55%) had Kaposi sarcoma (KS) and 4 patients (44.44%) had non melanoma skin cancer (NMSC). The mean age of the patients was 44.4 ±11.4 years. Eight patients (88.88%) were male. The mean time to development of Kaposi sarcoma and NMSC development was 9.1 months and 5.75 years, respectively. Three patients (60%) with Kaposi sarcoma had lesions on lower extremities and all the NMSCs were located in the head and neck region. Outdoor occupations were seen in at least 50% of NMSCs.Conclusion: This study again showed the importance of regular dermatologic examination for early diagnosis of skin malignancies, particularly, in high risk groups including renal transplant recipients.
Dehghani Leila; Khanjani Narges; Bahrampour Abbas
Volume 15, Issue 4 , 2012, , Pages 111-116
Abstract
Background: Skin cancers are the most common human cancers.The most common skin cancers are basal cell carcinoma, squamouscell carcinoma and malignant melanoma. Different factors areinvolved in development of skin cancers; the most notable oneis exposure to ultraviolet radiation. In this study, the incidenceof ...
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Background: Skin cancers are the most common human cancers.The most common skin cancers are basal cell carcinoma, squamouscell carcinoma and malignant melanoma. Different factors areinvolved in development of skin cancers; the most notable oneis exposure to ultraviolet radiation. In this study, the incidenceof skin cancer was determined in Kerman province where islocated in the desert region of Iran with ample sunlight, duringa 5–year period.Method: All registered cases of skin cancers between March2005 and March 2010 were retrieved from the Kerman ProvinceCancer Registry. For each patient, data about age, gender,location, pathologic type of cancer and site of skin involvement,were obtained. Incidence rates according to the age, sex and thelocation of the lesions were calculated. Trend analysis was donefor the next 10 years.Result: During these 5 years, 1250 cases of skin cancer wererecorded. The incidence in men was 1.2 times higher than women.The highest incidence was seen in individulas older than 80 yearsof age. Fifty percent of all skin cancers were located on the face.The highest incidence was observed in the city of Kerman withan annual incidence of 12.6 in 100,000. Trend analysis showedthat the incidence of skin cancer in Kerman province would reach23 in 100 000 people in 2019, which is 2.3 times higher than theincidence rate in 2009.Conclusion: Skin cancer is a public health concern in Kermanprovince in Iran. Considering the desert climate and the intensity ofsunlight in most seasons, it is necessary to plan scientific practicalinterventions to prevent skin cancer and reduce its incidence..
Z Nilforooshan; A Asilian; MA Nilforoosh Zadeh
Volume 8, suppl , 2004, , Pages 11-16
Abstract
Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most frequent skin cancers. The etiology of these tumors is multifactorial: Environmental and exogenous factors, genotype and phenotype factors. The development of malignant neoplasms at sites of previous dermal scars is an uncommon ...
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Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most frequent skin cancers. The etiology of these tumors is multifactorial: Environmental and exogenous factors, genotype and phenotype factors. The development of malignant neoplasms at sites of previous dermal scars is an uncommon but well recognized phenomenon, and since almost all of them were developed on exposed areas it has been hypothesized that the accompanying atrophy and decreased vascularity and adnexal structures in areas of scarring may render the affected tissues more susceptible to the effects of environmental factors, eg. ultraviolet light. We report four cases of BCC and SCC on old leishmania scars on face, and recommend that any changes on scars must be evaluated clinically and pathologically.
R Yaghoobi; N Sina; K Saedi
Volume 6, Issue 3 , 2003, , Pages 39-43
Abstract
Association of lichen planus and cutaneous malignancies is rare. Reports of neoplastic changes are mostly related to buccal chronic erosive lichen planus. We report herein a 29-year-old man who developed squamous cell carcinoma on previous lesions of chronic hypertrophic lichen planus of lower legs. ...
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Association of lichen planus and cutaneous malignancies is rare. Reports of neoplastic changes are mostly related to buccal chronic erosive lichen planus. We report herein a 29-year-old man who developed squamous cell carcinoma on previous lesions of chronic hypertrophic lichen planus of lower legs. Careful follow up of patients with chronic lichen planus and biopsy sampling of uncommon lesions is required to rule out malignant transformation.
Z Rahnama; AA Haghdoost
Volume 6, Issue 1 , 2002, , Pages 10-15
Abstract
Background: Squamous cell carcinoma has a wide range of histological differentiation, which indicates the prognosis. Location of the tumor also affects its prognosis. Objective: To determine the relationship between location of the tumor, age and sex of patients and histological grading of it. Patients ...
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Background: Squamous cell carcinoma has a wide range of histological differentiation, which indicates the prognosis. Location of the tumor also affects its prognosis. Objective: To determine the relationship between location of the tumor, age and sex of patients and histological grading of it. Patients and Methods: In this retrospective study, 44631 files of the patients who were referred to two main pathological centers in Kerman from 1992 to 1999 were reviewed, and the data of 186 cases of skin squamous cell carcinoma were extracted and analyzed. Results: In 186 cases of skin squamous cell carcinoma, the mean age of patients was 60.4±16.6 years. 133 patients (70.9%) were male and 53 cases (29.1%) were female, so male to female ratio was 2.5 to 1. The most common sites of involvement were head and neck (76.8%), upper extremities (10.2%), trunk and genitalia (6.8%) and lower extremities (6.2%). 81.5% of tumors were well differentiated, 14.3% were moderately and 4.2% were poorly differentiated. There was no relationship between age, sex and site of the lesion with grading of the tumor. Conclusion: In order to manage squamous cell carcinoma properly, performing biopsy in all cases is mandatory.