Kaliaperumal Karthikeyan; Iswarya Arumugam; Vijayasankar Palaniappan
Abstract
Porokeratosis is a heterogeneous group of keratinization disorderswith an autosomal dominant inheritance pattern. The etiology andpathogenesis of this disease have not been completely elucidated.The porokeratosis clinically presents with a characteristic prominentperipheral ridge and central dell. The ...
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Porokeratosis is a heterogeneous group of keratinization disorderswith an autosomal dominant inheritance pattern. The etiology andpathogenesis of this disease have not been completely elucidated.The porokeratosis clinically presents with a characteristic prominentperipheral ridge and central dell. The histological feature of theparakeratotic column known as ‘cornoid lamellae’ is a hallmarkfeature observed in the peripheral rim. Among the variousmorphological forms, linear porokeratosis is a rare variant withfour subtypes. When compared to other forms, the linear variantcarries an increased risk of malignancy, particularly squamouscell carcinoma, warranting a regular follow-up. Though there aremultiple treatment options, achieving complete clinical resolutionis difficult. We report an interesting case of linear porokeratosiswith generalized lesions in a 60-year-old male. The lesions weretypical and predominantly distributed in the extremities. Thebiopsy was diagnostic in our patient. This case is reported forits rare presentation and clinical interest.
Ali Asilian; Samaneh Mozafarpoor; Azadeh Goodarzi; Mohammad Amin Jafari; Parvin Rajabi; Mehdi Eftekhari
Abstract
Composite hemangioendothelioma (CHE) is a rare and little-known condition with combined benign, intermediate, and malignant features. In the current study, we describe the case of a young female with the presentations of CHE, representing the second known case in Iran. Also, we have comprehensively reviewed ...
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Composite hemangioendothelioma (CHE) is a rare and little-known condition with combined benign, intermediate, and malignant features. In the current study, we describe the case of a young female with the presentations of CHE, representing the second known case in Iran. Also, we have comprehensively reviewed previous case reports of CHE. A 30-year-old female was referred with a reddish hemorrhagic painless mass in the small right finger that appeared within a few days following trauma. The mass was primarily excised but recurred within three weeks; therefore, she underwent thorough clinical, laboratory, and imaging studies. Finally, the lesions were biopsied and diagnosed as CHE. Accordingly, the involved finger was amputated, and the patient underwent chemoradiotherapy. Although CHE is a rare malignant condition worldwide, attention to the clinical presentations of this malignancy can help scientists make better therapeutic approaches leading to the best outcomes.
R Yaghoobi; AA Aliari; N Emad Mostovfi; SM Latifi
Volume 8, Issue 1 , 2004, , Pages 24-31
Abstract
Background: The incidence of oral cancers is different worldwide. Objective: To evaluate the rate of oral cancers in Khouzestan Province. Patients and Methods: The data were collected from the pathologic reports of pathology laboratories all around the province, during the time period of 1992-2002. Results: ...
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Background: The incidence of oral cancers is different worldwide. Objective: To evaluate the rate of oral cancers in Khouzestan Province. Patients and Methods: The data were collected from the pathologic reports of pathology laboratories all around the province, during the time period of 1992-2002. Results: Among the total received specimens, 305 cases of oral cancers were detected. One hundred ninety-three cases (63.2%) were male and 112 cases (36.8%) were female. Male to female ratio was 1.7 and mean age was 55.04±16.60 years. Squamous cell carcinoma was the most common malignancy (75% of total), and then standed the nasopharyngeal carcinoma (10.8%) and lymphoma (7.5%). The most common sites were lower lip (29.2%), tongue (19%) and nasopharynx (15.7%). Conclusion: Regardless of some minor differences, most of our findings were similar to other previous studies.
M Seylanian Toosi; F Homaiee; HR Raziee
Volume 7, Issue 4 , 2004, , Pages 242-246
Abstract
Background: Neurofibromatosis 1 (NF1) is a relatively common autosomal dominant condition. Among the complications of the disease, such as neurological disorders, hypertension and skeletal deformities, malignancy is the most serious one and is the main cause of early death in these patients. Objective: ...
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Background: Neurofibromatosis 1 (NF1) is a relatively common autosomal dominant condition. Among the complications of the disease, such as neurological disorders, hypertension and skeletal deformities, malignancy is the most serious one and is the main cause of early death in these patients. Objective: Review of cases of NF-1 associated with malignancies. Patents and Methods: In a retrospective, descriptive study, 17 patients with malignancy and NF1 disease referred to oncology department of Qaem and Omid Hospitals (Mashhad) in a 10-year-period between 1993 and 2003 were reviewed. Results: 11 patients were male and 6 were female. The median age of patients was 23 years. We observed 9 cases with malignant peripheral nerve sheath tumors, 4 with CNS malignancies, 2 with rhabdomyosarcoma and one case with breast carcinoma. Conclusion: Regarding the importance of early diagnosis of these malignancies, and especially considering the young age of involved patients, it is logical to plot a schedule to examine the NF1 patients periodically. Physicians who are in contact with these patients should educate them to be aware of any suspicious signs and symptoms of malignancy.
R Yaghoobi; N Sina; K Saedi
Volume 6, Issue 3 , 2003, , Pages 39-43
Abstract
Association of lichen planus and cutaneous malignancies is rare. Reports of neoplastic changes are mostly related to buccal chronic erosive lichen planus. We report herein a 29-year-old man who developed squamous cell carcinoma on previous lesions of chronic hypertrophic lichen planus of lower legs. ...
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Association of lichen planus and cutaneous malignancies is rare. Reports of neoplastic changes are mostly related to buccal chronic erosive lichen planus. We report herein a 29-year-old man who developed squamous cell carcinoma on previous lesions of chronic hypertrophic lichen planus of lower legs. Careful follow up of patients with chronic lichen planus and biopsy sampling of uncommon lesions is required to rule out malignant transformation.
