Afsaneh Sadeghzadeh-Bazargan; Elham Behrangi; Azadeh Goodarzi
Abstract
Nowadays, the coronavirus disease 2019 (COVID-19) pandemic has become a global health problem and, given the high mortality and transmission rate of this infection and the lack of approved or specific treatments for it so far, the exploitation of the potentials of existing drugs is of paramount importance, ...
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Nowadays, the coronavirus disease 2019 (COVID-19) pandemic has become a global health problem and, given the high mortality and transmission rate of this infection and the lack of approved or specific treatments for it so far, the exploitation of the potentials of existing drugs is of paramount importance, hence, we aimed to investigate all possible COVID-19-related mechanisms of systemic retinoids. We systematically searched all related evidence in various data bases about the effect of retinoic acids on respiratory failure as the most important COVID-19-related complication and the other important potentials of this drug to affect COVID pathomechanism. Considering the various behaviors and presentations of this virus in different people, paying attention to the underlying diseases, physical conditions, genetics, and medications that cause these differences may be helpful in reducing the mortality and morbidity of the disease. In the field of dermatology, retinoids are a group of drugs that have controversial evidence regarding their effects when administered to patients with COVID-19. On one hand, these drugs offer immunomodulatory, immuneenhancing, antiviral, and antiangiogenesis activity, and can stimulate the differentiation and repair of epithelial cells. On the other hand, they can increase inflammation and cause the fragility of oral and nasal mucosae. When prescribe systemic retinoids, all of these aspects should be considered in all fields of the medicine and dermatology is not an exception.
Mortazavi Hossein; Aghazadeh Nessa; Ghiasi Maryam; Lajevardi Vahideh
Volume 16, Issue 4 , 2013, , Pages 144-158
Abstract
Retinoids are synthetic and natural analogues of vitamin A that have various effects on cellular differentiation, cellular proliferation, immune system, and embryonic development. The present study reviews the history of systemic retinoids in medicine, the structure of syn
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Retinoids are synthetic and natural analogues of vitamin A that have various effects on cellular differentiation, cellular proliferation, immune system, and embryonic development. The present study reviews the history of systemic retinoids in medicine, the structure of syn
M Barzegari; H Ghaninejad; M Shizarpoor
Volume 7, Issue 4 , 2004, , Pages 237-241
Abstract
Background: Psoriasis treatment is very important regard to mental sequeler and creating morbidity. First line treatment of generalized plaque type psoriasis includes methotrexate, phototherapy and retinoids. Objective: To compare bath-PUVA and acitretin in the treatment of generalized plaque type psoriasis. ...
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Background: Psoriasis treatment is very important regard to mental sequeler and creating morbidity. First line treatment of generalized plaque type psoriasis includes methotrexate, phototherapy and retinoids. Objective: To compare bath-PUVA and acitretin in the treatment of generalized plaque type psoriasis. Patients and Methods: 40 patients with generalized plaque type psoriasis with PASI scores of 15-20 in Razi Hospital in Tehran were randomly divided into 2 groups after giving consent. Each group included 20 patients. The first group was treated three times a week with bath-PUVA and the second group was treated with acitretin 0.7 mg/kg/day. The efficacy of 2 treatment regimens were determined and compared using PASI scores. Results: The clearance rate was 65% in bath-PUVA group and 75% in acitretin group. Patients in bath-PUVA needed 29 sessions and accumulative dose of 105.46 J/cm² for clearance. Conclusion: Psoriasis patients responded to bath-PUVA treatment but this response required more sessions and higher total dose. The inherent differences and distinctive responses to light in the patients under study (In Iran) compared with patients with skin phototypes I, II might explain these differences.
M Farshchian; M Pilevar
Volume 4, Issue 1 , 2000, , Pages 26-30
Abstract
Background: Pityriasis rubra pilaris (PRP) is a rare skin disease characterized by follicular hyperkeratosis, perifollicular erythema with islands of normal skin scattered over the sheets of erythroderma, palmoplantar hyperkeratosis and pityriasis capitis with unknown etiology. Objective: This study ...
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Background: Pityriasis rubra pilaris (PRP) is a rare skin disease characterized by follicular hyperkeratosis, perifollicular erythema with islands of normal skin scattered over the sheets of erythroderma, palmoplantar hyperkeratosis and pityriasis capitis with unknown etiology. Objective: This study has been done in order to determine the demographics, clinical and therapeutic aspects of PRP patients who were admitted to the dermatology ward of Sina Hospital in Hamadan in 1991-1999. Patients and Methods: This was a case series study, which the essential information was gathered by referring to the patients’ files. Then the obtained information was analyzed by SPSS software. Results: As PRP is a rare disease. Only 8 patients were identified. Five of them (61.5%) were men and 3 (37.5%) were women. The highest age of PRP patients was 66 years and the lowest was seven. The mean age of the patients was 32±19.4 years. None of the patients mentioned a positive family history. Six (75%) of the PRP patients suffered from Type I and two patients (25%) from Type III. Five patients (62.5%) were completely cured, all treated with retinoids, and three patients (37.5%) were partially cured, all treated with methotrexate. There was no case showing failure of the treatment. Conclusion: In this study the number of men was more than women. All of our patients suffered from Type 1 adult onset (Classic) or Type III juvenile onset. Retinoids showed more efficacy than methotrexate in the treatment of PRP.