Akbar Mokhtarpour neilagh; Farzam Alizadeh; Mehdi Aghazadeh Barenji; Shahin Behrouz Sharif; Amin Sedokani
Abstract
Background: Vitiligo is an acquired disorder characterized by the selective destruction of melanocytes, culminating in white macules on the skin. It usually begins at an early age; however, late-onset vitiligo also may occur. The disease burden arising from the psychological effects, ...
Read More
Background: Vitiligo is an acquired disorder characterized by the selective destruction of melanocytes, culminating in white macules on the skin. It usually begins at an early age; however, late-onset vitiligo also may occur. The disease burden arising from the psychological effects, especially during childhood, highlights the importance of epidemiological studies of this disease and investigations of differences of disease features between earlyonset and late-onset forms.Methods: A total of 234 vitiligo patients were included in this study and divided into two groups considering the age of onset. The disease characteristics and clinicopathological features of the patients were obtained and compared using written questionnaires.Results: Overall, 25.6% of patients were early-onset and the mean of age in this group was 18.86 years compared with 37.14 years in the late-onset group. The most frequent involvement sites for the early-onset and late-onset groups were the eyelid and hand, respectively. A significant difference was observed between the groups regarding thyroid disorder as a comorbid disease.Conclusion: Marked differences in clinical features were present between patients with early-onset and late-onset vitiligo. Females were more prevalent in the early-onset group and the frequency of thyroid disorder was less relative to the late-onset group. Further studies with different age cut-offs for categorizing early and late-onset vitiligo seem necessary.
Siddalingappa Karjigi; Murthy Sambasiviah Chidambara; Herakal Kallappa; Deepika Madagondanahalli
Volume 20, Issue 2 , 2017, , Pages 50-53
Abstract
Background: Chronic urticaria (CU) is a common skin disorder that accounts for 15%-20% of dermatological cases. There is growing evidence that some cases of chronic idiopathic urticarial (CIU) are associated with various autoimmune diseases, including thyroid autoimmunity. This study aims to identify ...
Read More
Background: Chronic urticaria (CU) is a common skin disorder that accounts for 15%-20% of dermatological cases. There is growing evidence that some cases of chronic idiopathic urticarial (CIU) are associated with various autoimmune diseases, including thyroid autoimmunity. This study aims to identify the thyroidprofile, including thyroid autoantibodies, in patients with CU.Methods: This case-control study included 100 patients with CU and 100 controls without urticaria. Males and females (age range: 20-40 years) who attended the Navodaya Medical College Hospital and Research centre were included. Participants underwent laboratory investigations that consisted of a complete blood count(CBC) thyroid autoantibodies, and other relevant investigations. Results: Patients in the CU group had a male to female ratio of 1:2.1 and a mean age of 31.2 years. The control group had a male to female ratio of 1:1 and a mean age of 35 years. Antimicrosomal antibodies (AMA) were present in 14 (14%) patients, 13 females and 1 male. There were no autoantibodies in any of the control group participants. Among these 14 patients, 5 (35.71%) had elevated serum thyroid stimulating hormone (TSH) and one had coexistent anti-thyroglobulin antibodies. Other associated diseases included diabetes mellitus, human immunodeficiency virus (HIV), and hepatitis B surface antigen (HBsAg) in onepatient each.Conclusion: Thyroid autoantibodies may play a role in persistent CU. Screening patients with persistent CU for thyroid functions, including thyroid autoantibodies, may help with proper management.
Mahboobeh-sadat Hosseini; Amir Hushang Ehsani; Vahideh-sadat Lajvardi; Maryam Ghiasi; Pedram Mehryan; Shideh Yazdanian; Ali Naser Tork; Reza Mahmood Robati
Volume 10, Issue 1 , 2007, , Pages 60-73
Abstract
Cutaneous manifestations of thyroid diseases can be divided into three groups:1-Specific lesions such as the thyroglossal duct cyst and cutaneous metastases form thyroid malignancy.2-Nonspecific signs secondary to thyroid hormone imbalance.3-Cutaneous signs of associated systemic and dermatologic disorders.This ...
Read More
Cutaneous manifestations of thyroid diseases can be divided into three groups:1-Specific lesions such as the thyroglossal duct cyst and cutaneous metastases form thyroid malignancy.2-Nonspecific signs secondary to thyroid hormone imbalance.3-Cutaneous signs of associated systemic and dermatologic disorders.This review constitutes a summary and update of the cutaneous manifestations of thyroid diseases.
