Kara Adistri; Windy Keumala Budianti; Rhida Sarly Amalia
Abstract
Pityriasis lichenoides chronica (PLC) is a chronic skin disorder with unknown etiology. This disorder still poses difficulty in diagnosis and treatment. Currently, there is no guideline established for the treatment of PLC. Most of the proposed therapy show transient or limited effects. Combination therapy ...
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Pityriasis lichenoides chronica (PLC) is a chronic skin disorder with unknown etiology. This disorder still poses difficulty in diagnosis and treatment. Currently, there is no guideline established for the treatment of PLC. Most of the proposed therapy show transient or limited effects. Combination therapy is usually the best approach. A 40-year-old man presented with erythematous papules appearing recurrently in crops in the last nine months localized mainly to the trunk and proximal extremities. A complete response was not achieved with topical and systemic corticosteroids. The combination of narrowband UVB phototherapy and cyclosporine showed satisfying results following a short duration of therapy. A complete response was seen after eight sessions of narrowband UVB phototherapy. No side effects were observed. The combination therapy of phototherapy and cyclosporine is a potential choice that needs to be considered in the management of PLC.
Delara Babaie; Shabnam Eskandarzadeh; Rudolf Valenta; Mehrnaz Mesdaghi
Abstract
Atopic dermatitis (AD) is a chronic allergic inflammation of the skin. Precise identification of the causative allergen is an important step in the successful treatment of patients with moderate to severe AD. Common diagnostic methods in allergy assess the presence or absence of allergen-specific sensitization, ...
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Atopic dermatitis (AD) is a chronic allergic inflammation of the skin. Precise identification of the causative allergen is an important step in the successful treatment of patients with moderate to severe AD. Common diagnostic methods in allergy assess the presence or absence of allergen-specific sensitization, but none exhibits a complete clinical correlation. Component-resolved diagnostics (CRD) is a new precise method for identifying the culprit allergen. Here, we report the case of a nine-year-old boy with severe AD. He was polysensitized (based on a skin prick test), with a poor response to routine AD therapeutic measures and food elimination diets. He had experienced recurrent flares while under treatment. Skin biopsy confirmed AD. Systemic therapy with cyclosporine (200 mg per day) was initiated and caused significant symptom relief within eight weeks. However, he had a flare when the dose was decreased to 150 mg daily. The causative allergen was diagnosed based on CRD, and he was successfully treated by allergen immunotherapy. CRD can determine the causative allergen in selected polysensitized patients with AD with poor response to treatment. The application of allergen-specific immunotherapy in AD management is controversial, but highly sensitized patients could benefit from it once the diseasecausing allergen is identified.
Sepaskhah Mozhdeh; Mohammadi Ali; Nabavizadeh Sara Sadat; Faridi Pouya; Babaei Amir Hossein
Abstract
Background: Acne vulgaris is a multi-factorial disease affecting many aspects of life. This study was conducted to compare the efficacy of fenugreek seed extract and oral azithromycin in the treatment of acne vulgaris. Methods: A total of 20 patients with acne vulgaris aged between 12 and 30 years old ...
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Background: Acne vulgaris is a multi-factorial disease affecting many aspects of life. This study was conducted to compare the efficacy of fenugreek seed extract and oral azithromycin in the treatment of acne vulgaris. Methods: A total of 20 patients with acne vulgaris aged between 12 and 30 years old were entered into this 60-day, randomized, placebo-controlled, triple-blind study. The patients were randomly divided into two groups, (permuted block randomization, block size of 4), namely fenugreek and azithromycin groups. All the participants daily received two capsules containing 500 mg hydroalcoholic extract of fenugreek seeds or 125mg azithromycin, for two months. The patients were evaluated after 30 and 60 days from the start of the trial. The participants, investigators (the dermatologists who evaluated clinical responses), and statisticians who analyzed the data were blind for identity and allocation of the treatments. Results: The baseline GAGS scores in azithromycin and fenugreek groups were respectively equal to 19.66 and 23.12, and there was a reduction in both azithromycin (GAGS2=14.33) (P-value=0.019) and fenugreek extract group (GAGS2=22.75) (P-value=0.780) during the experiment. There was a statistically significant difference among the two groups (F= (2, 24) = 3.861, P=0.035). Conclusion: The effect of azithromycin was higher than fenugreek in the treatment of acne vulgaris.
Nasiri Soheila; Hejazi Somayeh; Safoura Shakoei; Zahra Asadi; Nazi Saljoughi
Abstract
Granuloma faciale (GF) is a benign disease that presents as solitary or multiple asymptomatic plaques on the face. We report a 25-year-old male patient with asymptomatic papular, pustular, and nodular lesions on both cheeks. Diagnosis of GF was made based on the histopathological findings. He was treated ...
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Granuloma faciale (GF) is a benign disease that presents as solitary or multiple asymptomatic plaques on the face. We report a 25-year-old male patient with asymptomatic papular, pustular, and nodular lesions on both cheeks. Diagnosis of GF was made based on the histopathological findings. He was treated with cryotherapy and intralesional triamcinolone injections every month. After 3 months, the lesions became paler and less indurated.
