Nafiseh Esmaily; Amirhooshang Ehsani; Pedram Noormohammadpour; Iman Baiagouy; Shima Sayanjali
Volume 13, Issue 4 , 2010, , Pages 118-121
Abstract
Background: Pemphigus vulgaris (PV) is a rare autoimmune blistering disease with a high rate of morbidity and mortality without treatment. Until now, treatments consist mostly of the use of corticosteroid and immunosuppressive drugs. Optimum dosage for corticosteroid therapy is yet to be determined. ...
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Background: Pemphigus vulgaris (PV) is a rare autoimmune blistering disease with a high rate of morbidity and mortality without treatment. Until now, treatments consist mostly of the use of corticosteroid and immunosuppressive drugs. Optimum dosage for corticosteroid therapy is yet to be determined. The aim of the present study was to clear whether different initial corticosteroid therapeutic dosages change the recurrence rate of the disease.Methods: Patients hospitalized with confirmed PV from 2000 to 2006 were enrolled if they received systemic corticosteroids without any adjuvant therapy for no more than three weeks when hospitalized, received their first treatment in the period of the study and were followed for at least two years in the PV clinic of Razi Hospital periodically. Initial steroid dosage as well as the number and type of the recurrence(s) were documented and analyzed.Results: A total of 62 patients with a mean age of 46.8 (± 15.9) were enrolled. Twenty-one patients were female (33.9%) and 41 patients (66.1%) were male. According to the initial dose of systemic corticosteroid, patients were divided into two groups: group A included patients treated with less than 2mg/kg (10 patients or 16.1%) while group B included patients treated with 2mg/kg systemic steroids (52 patients or 83.9%). There was no significant difference in the recurrence rate between the two groups. Recurrence rate was 40% in group A and 51% in group B (P>0.05). According to the type of recurrence, there was a significant difference between the two groups; in group A, the first recurrence was major in 33% of the patients while in group B, this rate was about 28.8% (P<0.05).Conclusion: According to the present study, initial therapeutic dosage did not influence the recurrence rate although the type of recurrence was influenced. Patients treated with higher initial steroid dosages experienced their first episode as a minor recurrence while patients treated with lower initial steroid dosages experienced major recurrences with a higher probability as their first episode.
Behrooz Barikbin; Afsaneh Maarefat; Rayhaneh Rahgoshai; Hamideh Moravvej; Nahid Mohtasham; Maryam Yousefi
Volume 13, Issue 4 , 2010, , Pages 131-134
Abstract
Background: Hand eczema is one of the most common dermatologic diseases requiring treatment but common therapeutics such as corticosteroids and anti-histamines have numerous side effects. So, use of herbal agents, which generally have no major side effects, may be useful especially if their efficacy ...
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Background: Hand eczema is one of the most common dermatologic diseases requiring treatment but common therapeutics such as corticosteroids and anti-histamines have numerous side effects. So, use of herbal agents, which generally have no major side effects, may be useful especially if their efficacy is established. Malva Sylvestris (MS) is a tropical plant in Iran with cooling characteristics. Hence, in this study, its efficacy in of the treatment of hand eczema was evaluated. Methods: In this randomized clinical trial, 50 patients with hand eczema who were visited at Shohada-e Tajrish and Loghman hospitals, Tehran, Iran, between 2006 and 2008, were recruited and divided into two groups. In the first group, MS 4% ointment was applied twice a day and in the other group, placebo ointment was usd. The efficacy and side effects were evaluated three and six weeks after beginning of the treatment. Results: Mean age of the patients was 37.3 years and 35.6 years in MS and placebo groups, respectively (P > 0.05). There were no therapeutic adverse effects in the groups. There was a statistically significant difference in all measured scores between two groups in the first and second follow-up sessions (P < 0.0001). Conclusion: Malva Sylvestris seems to be a safe and effective therapeutic modality for the treatment of hand eczema and can be used as an optimal substitute for corticosteroids and antihistamines.
Supreeti Biswas; Kanchan Kumar Mondal; Indranil Saha; Rathindra Nath Dutta; Saibendu Kumar Lahiri
Volume 13, Issue 2 , 2010, , Pages 37-41
Abstract
Introduction: Acne vulgaris is a frequently encountered skin disease in daily practice. Its clinico-epidemiological status was evaluated in this study.Methods: Four hundred patients were studied by record-based observation for 2 years in the Acne Clinic of a tertiary care hospital.Results: This study ...
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Introduction: Acne vulgaris is a frequently encountered skin disease in daily practice. Its clinico-epidemiological status was evaluated in this study.Methods: Four hundred patients were studied by record-based observation for 2 years in the Acne Clinic of a tertiary care hospital.Results: This study revealed a male preponderance (53%) with a higher prevalence in adolescents (75%). Women with a regular menstrual cycle had a lower acne grading (ρ = – 0.31). Increased physical activity led to a decrease in acne grading (ρ = – 0.20). An association was found between acne and family history (42%) and nonvegetarian, oily, spicy fast food (99%). Our prescribed allopathic treatment in the Acne Clinic showed improvement. No drug induced ocular toxicity was observed. Hot, humid, dusty environment influenced the majority (87%) of the respondents. Urbanization (69%) increased the occurrence of acne.Conclusion: Community based studies are required to find out the actual burden of acne vulgaris.
Tabari Soudabeh Tirgar; Moghadam Nia Ali Akbar; Hajian Karimollah; Moeinzadeh Amirmajid
Volume 12, Issue 4 , 2009, , Pages 106-110
Abstract
Introduction: Topical antimicrobials, such as clindamycin, are effective in the treatment of acne and azelaic acid, due to the lack of bacterial resistance, could be a useful alternative in topical treatment of acne. The aim of this study was to compare the effect of topical azelaic acid 20% with clindamycin ...
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Introduction: Topical antimicrobials, such as clindamycin, are effective in the treatment of acne and azelaic acid, due to the lack of bacterial resistance, could be a useful alternative in topical treatment of acne. The aim of this study was to compare the effect of topical azelaic acid 20% with clindamycin 1% lotion for the treatment of acne. Method: This randomized clinical trial study was performed on 108 patients with mild and moderate acne. Patient were randomly assigned to one of the two groups of treatment with azelaic acid 20% cream (50 patients) or clindamycin 1% lotion (58 patients). The patients were evaluated by grading and lesion counting methods before treatment and one month and two months after the treatment. Results: The mean age of the patients in clindamycin group and azalic acid was 19. 6±3. 9 and 20. 3±4. 5 years, respectively (P=0. 41). The mean score of acne severity decreased after treatment according to grading and lesion counting methods (P0. 05) Conclusion: Result showed that the azelaic acid 20% topical cream was as effective as clindamycin 1% lotion for treating mild to moderate acne.
Ehsani Amir Hooshang; Toosi Siavash; Noormohamadpour Pedram; Hosseini Mahboubeh; Nazeman Leila
Volume 11, Issue 4 , 2008, , Pages 143-146
Abstract
Background: Pityriasis rosea is an inflammatory skin disorder with a known response to erythromycin. Considering similarities between erythromycin and azithromycin and lesser adverse effects of the latter, in a pilot study, we gave azithromycin to seven patients with pityriasis rosea and observed a noticeable ...
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Background: Pityriasis rosea is an inflammatory skin disorder with a known response to erythromycin. Considering similarities between erythromycin and azithromycin and lesser adverse effects of the latter, in a pilot study, we gave azithromycin to seven patients with pityriasis rosea and observed a noticeable improvement. The aim of this study was to evaluate the efficacy of azithromycin in patients with pityriasis rosea.Methods: A double-blind, placebo-controlled clinical trial was performed in our clinic. Sixty patients over a period of 20 months were alternatively assigned to the treatment group or the placebo group. Patients in the treatment group received azithromycin, 250 mg/day, for 14 days. The response was categorized as complete response, partial response, or no response. All patients were followed up for 2 months.Results: Age at presentation, sex, and average duration of the disease were comparable in both groups. Complete response was observed in 19 patients (63.3 %) in the treatment group and two in the placebo group (p<0.0001).Conclusion: Oral azithromycin is effective in treating patients with pityriasis rosea.
C.Geilen Christoph
Volume 11, Issue 4 , 2008, , Pages 159-167
Abstract
Psoriasis is a chronic, genetically determined skin disease. A variety of biochemical and molecular biological alterations have been identified, but the pathogenesis of psoriasis is still not clear. For patients with mild to moderate psoriasis, topical therapies are generally used. However, approximately ...
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Psoriasis is a chronic, genetically determined skin disease. A variety of biochemical and molecular biological alterations have been identified, but the pathogenesis of psoriasis is still not clear. For patients with mild to moderate psoriasis, topical therapies are generally used. However, approximately one-third of the patients have a moderate to severe psoriasis and need a systemic therapy. Beside well known therapeutical approach
Nilforoushzadeh Afshar Mohammad Ali; Jaffari Fariba; Ansari Nazli; Moradi Shahram
Volume 10, Issue 3 , 2007, , Pages 181-186
Abstract
Background and aim: The scars of the cutaneous leishmaniasis and psychologic problems of this disease needs different intervention for its correction. Our objective in this study was to compare the efficacy of trichloroacetic acid (TCA) 50 percent solution and CO2 laser for treatment of the atrophic ...
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Background and aim: The scars of the cutaneous leishmaniasis and psychologic problems of this disease needs different intervention for its correction. Our objective in this study was to compare the efficacy of trichloroacetic acid (TCA) 50 percent solution and CO2 laser for treatment of the atrophic scars due to leishmaniasis. Materials and methods: This was a randomized clinical trial perfomed in 92 patients. Patients were randomized into 2 groups, first group were treated with TCA 50 percent solution, once monthly and for maximum of 5 months, second group were treated with CO2 laser that was performed for only one time. Patients were followed at 3 months and 6 months after starting treatment. The improvement of scar was graded by 6-point scale using digital camera and the collected data were analyzed using SPSS software and t, Wilcoxon and Mann-Whitney tests.Results: In this study that 74 females and 18 males were followed, the improvement of scar was 48.13% in the TCA group and 44.87% in the CO2 laser group. This difference was not statistically significant (P=0.55). There was also no significant difference regarding side effects between these 2 groups. Conclusion: The results of our study showed efficacy of topical treatment with 50 percent TCA solution is comparable with CO2 laser in the treatment of leishmaniasis scar. Because of the low cost and simple application of TCA solution in comparison with CO2 laser, we suggest the use of this treatment for correction of leishmaniasis or atrophic scars.
Farnaghi Farshad; Seirafi Hassan; Ehsani Amirhooshang; Tork Ali Naser; Yazdanian Shideh; Zarrin-nejad Neda
Volume 10, Issue 2 , 2007, , Pages 94-99
Abstract
Background and aim: Treatment of resistant warts is a common clinical problem. Immunotherapy with diphenyl cyclopropenone (DCP) as a contact sensitizer has been reported. The objective of this study was to evaluate the efficacy of DCP in refractory warts.Materials and methods: Nineteen patients with ...
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Background and aim: Treatment of resistant warts is a common clinical problem. Immunotherapy with diphenyl cyclopropenone (DCP) as a contact sensitizer has been reported. The objective of this study was to evaluate the efficacy of DCP in refractory warts.Materials and methods: Nineteen patients with refractory warts referred to Razi Hospital in 2004 who had not responded to at least 2 treatment modalities, were sensitized with 2% DCP in acetone.Then treatment was started with application of 1% DCP on plantar warts and 0.2% on other locations.Results: Two patients were not sensitized even after 3 attempts. Three other patients discontinuedtreatment due to side effects (severe eczema and pruritus). Six male and 8 female patients completed the trial, among them,10 (71.5%) showed complete clearance of warts. Side effects reported were: local pruritus (21%), distant eczema (10.5%), local blister (26.3%). The patients received a mean of 5 treatment sessions.Conclusion: Topical immunotherapy with DCP is an effective treatment for refractory warts. Due to high efficacy, no scarring, and being a painless procedure it can be considered as a first line treatment of refractory warts.
Mostafa Mirshams Shahshahani; Nafiseh Esmaili; Pedram Mehryan; Amir Houshang Ehsani; Siavash Toosi
Volume 10, Issue 1 , 2007, , Pages 2-8
Abstract
Background and aim : The clinical management of verrucae vulgaris is often challenging and no treatment is always effective. Early studies have suggested that pulsed-dye laser (PDL) may be highly effective in the treatment of verrucae through obliteration of dilated vessels in papillary dermis. The objective ...
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Background and aim : The clinical management of verrucae vulgaris is often challenging and no treatment is always effective. Early studies have suggested that pulsed-dye laser (PDL) may be highly effective in the treatment of verrucae through obliteration of dilated vessels in papillary dermis. The objective of this study was to compare safety and efficacy of 585 nm with 595 nm PDL in the treatment of warts.Materials and methods: The randomized controlled trial was done on forty patients with warts referred to Razi Hospital in Tehran. Almost symmetrically distributed warts were randomized to receive PDL 585 nm or 595 nm on their left or right side and a similar lesion with respect to size, thickness and location was not treated as control. Each patient was treated in three sessions at three- week intervals. Warts were individually examined at the time of each treatment session and their size and adverse effects of treatment recorded. Complete response was defined as complete disappearance of lesions.Results: Thirty-six patients completed the trial. The mean size of the lesions before the treatment were 19.7±13.2 mm2 in PDL 585 nm group and 21.7±15.4 mm2 in PDL 595 nm group. After the last treatment the mean reduction in size of warts were 18.1±12.3 mm2 and 18.1±11.2 mm2 and the lesions cleared in 27 (75%) and 25 (69%) patients in PDL 585 nm and PDL595 nm groups, respectively (P value =0.83). Variable degrees of purpura and pain were observed in all patients which was classified as severe in 15 and 16 cases in PDL 585 nm group and 19 and 18 cases in PDL 595 nm group, respectively (P=0.8).Conclusion: The PDL is an effective treatment for verrucae vulgaris and there are no statistically significant differences between 585 nm and 595 nm with respect of their efficacy and adverse effects.
Toosi Parviz; Dadras Mohammad Shahidi; Sadiqha Afshin; Farshi Hamideh Moravej
Volume 9, Issue 4 , 2006, , Pages 324-330
Abstract
Background and aim: It is possible to use light sources suxh as lasers to destruct melanosomes and treat pigmented skin lesions. One of the most commonly used laser systems is Q switched ruby laser with a wave-length of 694 nm. This study was performed to evaluate the efficacy of the Q switched ruby ...
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Background and aim: It is possible to use light sources suxh as lasers to destruct melanosomes and treat pigmented skin lesions. One of the most commonly used laser systems is Q switched ruby laser with a wave-length of 694 nm. This study was performed to evaluate the efficacy of the Q switched ruby laser in the treatment of pigmented skin lesions including lentigines (simplex or solar) and café-au-lait macules.Materials and Methods: After physical examination for ruling out the possibility of malignancy by two dermatologists, patients were treated with Q switched ruby laser. Response to treatment was categorized in four groups of equal interval according to the 0-100% lesion lightening.Results: Ninetyy patients including 81 patients with solar lentigo and 9 cases of lentigo simplex were recruited into this study. Mean±standard deviation (SD) of the number of treatment sessions for solar lentigo and lentigo simplex cases were 1.0 ± 0.5 and 3.6 ± 1.3 , respectively. Although the mean of sessions was increased in darker skin types, there was no statistically significant difference between different skin types (p=0.335). In addition, there was no significant relation between mean treatment sessions and location of the lesions (p=0.685). Cure rate was 100% in all lentigo cases and after a mean ±SD of 8.7±2.3 months follow up there was no recurrence. Also, there was neither pigmentary change nor folliculitis during treatment. In 7 cases with café-au-lait macules, the mean±SD score of improvement was 2.4 ± 0.8, which was achieved after 3.1±0.4 treatment sessions. In 6 cases whom were followed up for 10.2 ± 3.1 months, despite primary disappearance, recurrence of café-au-lait macules was observed. Conclusion: It seems Q switched ruby laser is an appropriate method for treatment of lentiginous lesions in caucasians with Fitzpatrick's skin types II to IV.
SM Davoudi; P Rostami; SN Emadi; B Sadr; E Khabiri
Volume 9, Issue 3 , 2006, , Pages 217-220
Abstract
Background and aim: Paederus dermatitis is an acute self-healing blistering disease caused by an insect from the genus Paederus species. Although it is a self-limited disease, it can cause disablement and suffering. The objective of this study was to investigate the efficacy of fluocinolone cream, triclocarban(TCC) ...
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Background and aim: Paederus dermatitis is an acute self-healing blistering disease caused by an insect from the genus Paederus species. Although it is a self-limited disease, it can cause disablement and suffering. The objective of this study was to investigate the efficacy of fluocinolone cream, triclocarban(TCC) soap and betamethasone lotion in comparison with placebo in the treatment of paederus dermatitis.Materials and Methods: This study was a randomized single blind placebo controlled trial which was performed in Behshahr hospitals during a period of two months. Seventy-seven patients with paederus dermatitis were randomized to treatment with fluocinolone cream, TCC soap, betamethansone lotion or a placebo. The conditon of each patient was checked three times; i.e., on their first, fifth and twelfth day of receiving treatment. Finally, depending on their response to treatment, they were divided into two groups, those who fully recovered and those failing to recover.Results: Of the 77 patients studied, 18 were treated with a placebo, 17 with betamethasone lotion, 24 with fluocinolone cream and 17 with TCC soap. Complete recovery at the end of treatment was fluocinolone 100% , betamethasone 100%, TCC 58.8% and placebo 33.3%. Significant differences were observed between two first groups and the placebo group (P=0.0001) but no significant difference was observed between TCC soap and placebo.Conclusion: Topical corticosteroids displayed a relative and significant improvement in paederus dermatitis.
M Maleki; Z Javidi; V Mashayekhi; MT Shakeri; Y Nahidi; MA Hamed Shojaei; M Hanifeh Zadeh
Volume 9, Issue 2 , 2006, , Pages 132-138
Abstract
Background and aim: In spite of the existance of different types of treatment for cutaneous leishmaniasis, an efficient, safe and cheap treatment has not been found yet. There are some studies showing antiparasiticidal effect of direct current electricity both in vivo and in vitro. The objective of this ...
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Background and aim: In spite of the existance of different types of treatment for cutaneous leishmaniasis, an efficient, safe and cheap treatment has not been found yet. There are some studies showing antiparasiticidal effect of direct current electricity both in vivo and in vitro. The objective of this study was to evaluate the effect of electrotherapy in treatment of cutaneous leishmaniasis.Materials and Methods: This trial was done on 16 patients referred to dermatology clinics of Mashhad University of Medical Sciences with cutaneous leishmaniasis. Twenty-seven lesions were treated in six weekly sessions for 10 minutes, by direct current electricity. The intensity ranged from 5 to 15 mA, and the voltage was kept below 40 volts. Ten lesions were left untreated as control group. At each session the size of induration was measured and recorded.Results: At the end of the trial, in the study group, the average of the induration size decreased 55±30% , however, in the control group the induration size increased 20±20% (P<0.05).Conclusion: Direct current electricity was effective in the treatment of cutaneous leishmaniasis to some extent. Further studies with alteration in method of this treatment are needed.
MJ Nazemi Tabrizi; N Esmaeili; Y Sedaghat; S Mostafa
Volume 9, Issue 1 , 2006, , Pages 46-48
M Bakhshi Zadeh; SH Hejazi; M Baghaei; F Jafari; Z Ghayour; A Khamesi Pour
Volume 8, Issue 4 , 2005, , Pages 260-265
Abstract
Background an objective: Leishmaniasis is a common disease endemic in some parts of Iran. Chemical or physical treatments or a combination of both are used for treatment of the disease. Nitric oxide (NO) is important for healing of leishmaniasis in human and animal. This study was designed to evaluate ...
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Background an objective: Leishmaniasis is a common disease endemic in some parts of Iran. Chemical or physical treatments or a combination of both are used for treatment of the disease. Nitric oxide (NO) is important for healing of leishmaniasis in human and animal. This study was designed to evaluate the beneficial effects of a NO releasing cream on cutaneous leishmaniasis in an animal model. Materials and Methods: Balb/c mice were infected with leishmania major by injecting promastigotes into the base of tails of mice to induce the lesion. Then the animals were divided into 3 groups (Control, placebo and treatment). Mice were treated with the drugs one time daily. The diameter of lesions were measured on days 0, 5, 10, 15, 20, 25, and 30 after the appearance of the lesions. Data were analyzed using one-way ANOVA test and (P<0.05) considered as significant. Results: The diameter of lesions were significantly reduced in 15, 20, 25 and 30 day in NO cream treated animals compared to control and placebo groups (P<0.05). Conclusion: NO releasing compounds may be effective in the treatment of leishmaniasis.
L Dastgheib; M Aziz Zadeh; P Jafari
Volume 8, Issue 2 , 2005, , Pages 88-92
Abstract
Background: Tinea capitis is a relatively common fungal infection in children. Although several oral anti-fungal agents have been used in the treatment of tinea capitis, griseofulvin has been considered as the treatment of choice for a long time. Objective: To compare the therapeutic effects of fluconazole ...
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Background: Tinea capitis is a relatively common fungal infection in children. Although several oral anti-fungal agents have been used in the treatment of tinea capitis, griseofulvin has been considered as the treatment of choice for a long time. Objective: To compare the therapeutic effects of fluconazole with griseofulvin on tinea capitis. Patients and Methods: Through a randomized, single-blinded, clinical trial on 40 clinically suspected an mycologically confirmed tinea capitis cases, 19 cases received oral fluconazole for 4 weeks and 21 patients were treated with griseofulvin for 6 weeks. All patients were evaluated clinically and mycologically before receiving their treatment and 8 weeks after the beginning of treatment. Results: The age range of the patients was from 1 to 16 years. Thirty-two cases were males. Mycology studies indicated that the causative agents were trichophyton verrucosum in 16 cases, trichophyton violaceum in 16 cases and microporum canis in 8 cases. At the end of the eighth week of the beginning of treatment, 15 cases were cured in the fluconazole group compared with 16 cases in the griseofulvin group (P>0.05). Conclusion: It seems that griseofulvin could be still considered as the first choice drug in the treatment of tinea capitis and fluconazole could be used as an alternative drug.
M Mirshams Shahshahani; E Aboo Saeidi
Volume 8, Issue 1 , 2004, , Pages 19-23
Abstract
Background: Epidermal nevus is a common skin hamartoma. Its definite treatment is difficult and in most cases the disease has recurrence. Objective: Evaluation of topical tretinoin 0.05% and 5 Fluorouracil (5FU) 5% in the treatment of epidermal nevus. Patients and Methods: Fifteen patients with epidermal ...
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Background: Epidermal nevus is a common skin hamartoma. Its definite treatment is difficult and in most cases the disease has recurrence. Objective: Evaluation of topical tretinoin 0.05% and 5 Fluorouracil (5FU) 5% in the treatment of epidermal nevus. Patients and Methods: Fifteen patients with epidermal nevus referred to skin clinic in Razi Hospital in Tehran whose diagnoses were confirmed by pathology examination, were treated with topical tretinoin 0.05% and 5FU 5%. Five patients were excluded because of loss to follow up and 10 patients were regularly followed. Results: Four patients were male and 6 of them were female. Their age ranged from 12 to 40 years. After 10 weeks, their nevi were flattened considerably so the patients were satisfied. There was no complication that needed to stop the treatment completely. Maintenance treatment was recommended and no recurrence was seen until the end of follow up duration. Conclusion: Topical tretinoin 0.05% and 5FU 5% are easy and inexpensive treatments for epidermal nevi, with satisfactory results and long maintenance therapy will prevent recurrence.
A Rasi; H Ansarin; MH Aziz Jalali
Volume 8, Issue 1 , 2004, , Pages 48-61
Abstract
Nowadays viral hepatitis is one of the most common and important causes of chronic liver disorders in the world. Extrahepatic manifestations of viral hepatitis consist a main part of the disease. The main viruses causing hepatitis include Hepatitis A, B and C viruses. Herein common skin manifestations ...
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Nowadays viral hepatitis is one of the most common and important causes of chronic liver disorders in the world. Extrahepatic manifestations of viral hepatitis consist a main part of the disease. The main viruses causing hepatitis include Hepatitis A, B and C viruses. Herein common skin manifestations in hepatitis C virus (HCV) are discussed. Chronic hepatitis causes skin disorders both directly and indirectly. HCV is a RNA virus and is considered as one of the most important causes of acute and chronic hepatitis. HCV is mainly transmitted through blood transfusion or using shared infected needles. People who inject narcotics, cocaine users and health personnel are at risk more than others.
H Ansarin; A Ghahhari; SF Akbarian
Volume 6, Issue 4 , 2003, , Pages 34-45
Abstract
The available treatment modalities for hypertrophic scars and keloids have very little success. Surgical treatment of these lesions without adjuvant therapy is also associated with high recurrence rate. Hypertrophic scars and keloids are the results of a series of cellular and molecular changes which ...
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The available treatment modalities for hypertrophic scars and keloids have very little success. Surgical treatment of these lesions without adjuvant therapy is also associated with high recurrence rate. Hypertrophic scars and keloids are the results of a series of cellular and molecular changes which their identification can guide us toward new treatment modalities which may decrease the pathological factors, or help balancing the repair mechanism; thus inhibiting extensive scar formation. In this article, we have reviewed the latest treatment methods, as well as molecular and cellular reactions, which lead to the formation of hypertrophic scars and keloids.
H Ansarin; A Ghahhari; SF Akbarian
Volume 6, Issue 3 , 2003, , Pages 27-34
Abstract
The available treatment modalities for hypertrophic scars and keloids have very little success. Surgical treatment of these lesions without adjuvant therapy is also associated with high recurrence rate. Hypertrophic scars and keloids are the results of a series of cellular and molecular changes which ...
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The available treatment modalities for hypertrophic scars and keloids have very little success. Surgical treatment of these lesions without adjuvant therapy is also associated with high recurrence rate. Hypertrophic scars and keloids are the results of a series of cellular and molecular changes which their identification can guide us toward new treatment modalities which may decrease the pathological factors, or help balancing the repair mechanism; thus inhibiting extensive scar formation. In this article, we have reviewed the latest treatment methods, as well as molecular and cellular reactions, which lead to the formation of hypertrophic scars and keloids.
MJ Yazdan Panah; SK Mostoufi; M Soleimani
Volume 6, Issue 2 , 2003, , Pages 20-24
Abstract
Background: Different local and systemic modalities are suggested in the treatment of cutaneous leishmaniasis (CL), but the pentavalent antimony compounds are still considered as the first line of treatment. Regarding to increase in clinical drug resistance, adverse effects and low compliance of patient, ...
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Background: Different local and systemic modalities are suggested in the treatment of cutaneous leishmaniasis (CL), but the pentavalent antimony compounds are still considered as the first line of treatment. Regarding to increase in clinical drug resistance, adverse effects and low compliance of patient, efforts for finding a more effective and safer drug continue. Objectives: To evaluate the efficacy of oral zinc sulfate in the treatment of acute dry CL. Patients and Methods: 31 patients with clinical diagnosis of acute, dry CL and positive direct smear for Leishman bodies were included in the trial. Patients were treated with 10 mg/kg/day oral zinc sulfate for 45 days and evaluated every 3 weeks during the period of treatment and also 1.5 months after cessation of it. Results: 22 patients completed the course of treatment. At the end of 45 days of treatment, only two cases (9%) were cured and the remaining did not show satisfactory response. Conclusion: Oral zinc sulfate has limited therapeutic value in the treatment of dry CL.
MA Nilforoosh Zadeh; MR Reiss Zadeh; F Jafari
Volume 6, Issue 2 , 2003, , Pages 34-39
Abstract
Background: An easy and effective topical treatment is not yet available for cutaneous leishmaniasis. Objectives: To compare the effect of topical trichloroacetic acid (TCA) and intralesional glucantime injection in the treatment of acute wet cutaneous leishmaniasis. Patients and Methods: Eighty patients ...
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Background: An easy and effective topical treatment is not yet available for cutaneous leishmaniasis. Objectives: To compare the effect of topical trichloroacetic acid (TCA) and intralesional glucantime injection in the treatment of acute wet cutaneous leishmaniasis. Patients and Methods: Eighty patients with clinical diagnosis of wet cutaneous leishmaniasis in the age range of 5 to 75 years were recruited in this open clinical trial. Seven patients were withdrawn during the trial. In TCA group, 38 patients were treated three times (Every 2 weeks) with 50% TCA. In control group, 35 patients received intralesional glucantime injection weekly until healing or for a maximum of 6 weeks. All patients were followed for 3 months after last treatment. Results: After four weeks of treatment, 20 patients (52.6%) in TCA group and 17 patients (48.5%) in glucantime group, and after six weeks, 68% and 65.7% of patients in each respective group were completely cured. There was no important side effect in any groups. Conclusion: The nearly equal efficacy of TCA peeling and intralesional glucantime injection in the treatment of cutaneous leishmaniasis suggests that 50% TCA could be considered as a possible efficient therapeutic alternative in the management of this disease.
A Zamanian; M Pilehvar
Volume 5, Issue 2 , 2002, , Pages 28-32
Abstract
Background: Pilomatricoma, the most common hair follicle tumor, has a wide variety of clinicopathological characteristics and is often misdiagnosed. Objective: The aim of this study was to explain the clinical and histological spectrum of tumor in order to help for its better diagnosis. Patients and ...
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Background: Pilomatricoma, the most common hair follicle tumor, has a wide variety of clinicopathological characteristics and is often misdiagnosed. Objective: The aim of this study was to explain the clinical and histological spectrum of tumor in order to help for its better diagnosis. Patients and Methods: In a retrospective descriptive study, the clinical and histological features of pilomatricoma were reviewed. The files and histologic sections of all biopsy specimens examined in Hamadan Sina Hospital between 1992 and 1999 were analyzed. Results: Among 4000 biopsy specimens, 22 cases of pilomatricoma were found. 59.3% of the lesions were located on upper extremities. The lesion developed in second decade of life in 36.5 percent of the patients. Shadow cells, calcifications, ossification and granulomatous reaction were detected in 100, 50, 9 and 45.5 percent of specimens, respectively. The accuracy of clinical diagnosis compared with pathologic findings was 36.5 percent. Conclusion: Pilomatricoma was the final diagnosis in 0.55 percent of all biopsy specimens examined in Hamadan Sina Hospital between the years 1992 to 1999. It should be included in differential diagnosis of skin tumors.
A Asilian; F Salehi
Volume 5, Issue 2 , 2002, , Pages 33-38
Abstract
Cryotherapy is a simple, safe and effective method for many benign and malignant skin diseases. If applied with an appropriate technique, the results will be very satisfactory and the complications will be very low. Herewith we will discuss cryotherapy and its applications in dermatology and review the ...
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Cryotherapy is a simple, safe and effective method for many benign and malignant skin diseases. If applied with an appropriate technique, the results will be very satisfactory and the complications will be very low. Herewith we will discuss cryotherapy and its applications in dermatology and review the advantages and disadvantages of this technique.
MA Mapar; H Kavoosi; MA Dabbagh
Volume 4, Issue 4 , 2001, , Pages 23-28
Abstract
Background: Cutaneous leishmaniasis (CL) is a common cutaneous disease in the middle-east countries such as Iran. Khoozestan is an endemic area for it. The importance of this disease is in the formation of an ugly scar on the face, which damages beauty. There hasn’t been any effective topical treatment ...
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Background: Cutaneous leishmaniasis (CL) is a common cutaneous disease in the middle-east countries such as Iran. Khoozestan is an endemic area for it. The importance of this disease is in the formation of an ugly scar on the face, which damages beauty. There hasn’t been any effective topical treatment for this disease yet. Objective: To assess the effect of topical opium in the treatment of CL. Patients and Methods: A double blind, placebo controlled study was performed in Ahwaz during 1378 and 1379. 96 patients were included in this study and treated with a topical preparation of opium or placebo. The inclusion criteria for patient were: age more than 2 years, number of lesion less than 6, duration of disease less than 3 months, not using any drug with anti-leishmaniasis effect and positive direct smear. Pregnant or nursing patients were excluded. Results: From 58 patients who completed the study, 34 patients were given topical opium, 5 (4.2%) of them got cured. From 24 patients who were given placebo, only 1 (4.2%) patient got cured. This study did not show a significant difference between response to drug and placebo (P=0.12, chi-square test). Conclusion: From this study suggested that high concentration of topical opium or combination of topical opium with other material to be carried out.
R Salmanpour; MJ Rahmanian
Volume 4, Issue 2 , 2001, , Pages 9-12
Abstract
Background: Severe axillary hyperhidrosis causes considerable emotional stress to individuals affected with this condition. Existing topical and surgical therapies are either ineffective or associated with unacceptable morbidity and sequelae. Objective: In this study we attempted to determine the effect ...
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Background: Severe axillary hyperhidrosis causes considerable emotional stress to individuals affected with this condition. Existing topical and surgical therapies are either ineffective or associated with unacceptable morbidity and sequelae. Objective: In this study we attempted to determine the effect of botulinum toxin A (Dysport) in the treatment of axillary hyperhidrosis. Patients and Methods: After visualization of hyperhidrosis using the iodine-starch test, ten patients with axillary hyperhidrosis underwent intradermal injection with 125 units of Dysport in the axillary skin bilaterally. Patients were observed for 7 months after treatment. Results: The treatment was well tolerated without side effects. All patients experienced relatively complete anhidrosis of the axillary skin after about one week for periods lasting from 4 to 7 months. Conclusion: Botulinum-A toxin may offer a fast, safe, and highly effective therapeutic option for severe hyperhidrosis.