Pedram Noormohammadpour; Somayeh Khezri; Zahra Safaee Naraghi; Alireza Ghanadan; Farzaneh Khezri
Volume 15, Issue 4 , 2012, , Pages 134-136
Abstract
Confluent and Reticulate Papillomatosis (CRP) is a rare disease withpoorly recognized etiology. Various agents such as antibacterial,topical/systemic antifungal and topical/oral retinoids have beenused as treatment. Here, we report a 15-year-old female withCRP in whom yeasts of Malassezia were found ...
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Confluent and Reticulate Papillomatosis (CRP) is a rare disease withpoorly recognized etiology. Various agents such as antibacterial,topical/systemic antifungal and topical/oral retinoids have beenused as treatment. Here, we report a 15-year-old female withCRP in whom yeasts of Malassezia were found in the PAS stainof the skin lesions. Topical terbinafine hydrochloride 1% sprayand oral fluconazole disappeared the lesions, supporting thehypothesis that CRP maybe a reactive dermatosis to Malassezia..
L Dastgheib; M Aziz Zadeh; P Jafari
Volume 8, Issue 2 , 2005, , Pages 88-92
Abstract
Background: Tinea capitis is a relatively common fungal infection in children. Although several oral anti-fungal agents have been used in the treatment of tinea capitis, griseofulvin has been considered as the treatment of choice for a long time. Objective: To compare the therapeutic effects of fluconazole ...
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Background: Tinea capitis is a relatively common fungal infection in children. Although several oral anti-fungal agents have been used in the treatment of tinea capitis, griseofulvin has been considered as the treatment of choice for a long time. Objective: To compare the therapeutic effects of fluconazole with griseofulvin on tinea capitis. Patients and Methods: Through a randomized, single-blinded, clinical trial on 40 clinically suspected an mycologically confirmed tinea capitis cases, 19 cases received oral fluconazole for 4 weeks and 21 patients were treated with griseofulvin for 6 weeks. All patients were evaluated clinically and mycologically before receiving their treatment and 8 weeks after the beginning of treatment. Results: The age range of the patients was from 1 to 16 years. Thirty-two cases were males. Mycology studies indicated that the causative agents were trichophyton verrucosum in 16 cases, trichophyton violaceum in 16 cases and microporum canis in 8 cases. At the end of the eighth week of the beginning of treatment, 15 cases were cured in the fluconazole group compared with 16 cases in the griseofulvin group (P>0.05). Conclusion: It seems that griseofulvin could be still considered as the first choice drug in the treatment of tinea capitis and fluconazole could be used as an alternative drug.
SZ Famili; F Pezeshk Poor; V Sepehr; M Vahedian
Volume 8, Issue 2 , 2005, , Pages 97-100
Abstract
Background: Cutaneous leishmaniasis is an important skin parasitic disease. Ideal treatment is not found yet and seeking for proper drugs continues. Objective: Comparison of the efficacy of fluconazole with systemic glucantime in patients with acute cutaneous leishmaniasis in Ghaem hospital in Mashhad ...
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Background: Cutaneous leishmaniasis is an important skin parasitic disease. Ideal treatment is not found yet and seeking for proper drugs continues. Objective: Comparison of the efficacy of fluconazole with systemic glucantime in patients with acute cutaneous leishmaniasis in Ghaem hospital in Mashhad in 2002. Patients and Methods: During one year of study, all patients with cutaneous leishmaniasis were divided to two group. Thirty-one patients were treated with oral fluconazole (100 mg twice a day) for 6 weeks and 29 patients were treated with intra-muscular glucantime (20 mgSb/kg) for 21 days. Both groups were evaluated 3 and 6 weeks after onset of treatment. T-test and Chi-square test were used for statistical analyses and (P0.05). Conclusion: It seems that efficacy of fluconazole in acute cutaneous leishmaniasis is lower than glucantime. A larger clinical trial is recommended.
F Handjani; M Nasseri
Volume 6, Issue 4 , 2003, , Pages 11-16
Abstract
Background: Tinea versicolor is a superficial fungal infection caused by normal skin flora and treatable by topical and oral anti-fungal medications. Objective: To evaluate the clinical and paraclinical response and to compare possible side-effects of a single oral dose of fluconazole and ketoconazole ...
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Background: Tinea versicolor is a superficial fungal infection caused by normal skin flora and treatable by topical and oral anti-fungal medications. Objective: To evaluate the clinical and paraclinical response and to compare possible side-effects of a single oral dose of fluconazole and ketoconazole in treatment of tinea versicolor. Patients and Methods: In this clinical trial, sixty-six definite cases of tinea versicolor were divided in two groups using a simple randomization method. The first group consisted of 33 patients who were treated with a single oral dose of 300mg of fluconazole. The second group also consisted of 33 patients who received ketoconazole 400mg orally as a single dose. The patients were evaluated 2 weeks after treatment for therapeutic and paraclinical responses as well as possible side effects. Results: Clinical and paraclinical responses were 60.6% and 78.7% in the first group (Fluconazole) and 33.3% and 51.5% in the second group (Ketoconazole), respectively (P<0.05): There was no statistical difference as far as side-effects were considered (P>0.05). Conclusion: The therapeutic effect of fluconazole as a single oral dose was more than ketoconazole in the treatment of tinea versicolor.