Efficacy of 5-Fluorouracil plus Epinephrine, Pulsed Dye Laser and Betamethasone on the Improvement of Psoriatic Plaques (A Comparative Study)
Soheila
Taheri
author
Ali
Asilian
author
Gita
Faghihi
author
text
article
2009
eng
Background: Many efforts are made to find new and more effective treatments for psoriasis. Intralesional 5-Fluorouracil (5-FU) +epinephrine is a cheap option which can be administered with long intervals. The effectiveness of Pulse Dye Laser (PDL) on psoriasis has been already assessed. We decided to evaluate the effectiveness of 5-FU+epinephrine and compare it to betamethasone and PDL.Methods: A group of 22 patients with chronic stable plaque psoriasis were included. Three plaques on each patient were treated with 5- FU+epinephrine, PDL and betamethasone, respectively. Psoriasis Severity Index (PSI) scoring was applied to assess each plaque before treatment and in weeks 2, 4, 6, 12, and 24. Photos of each plaque were taken before treatment and at each treatment and follow-up session. They were finally compared and scored by a dermatologist.Results: Decline in mean Psoriasis Severity Index (PSI) in week 6 (2 weeks after treatment) and in week 24 (the last follow-up session) was statistically significant as compared to baseline in all groups. (P<0.001) The highest decline in mean PSI score was in the 5-FU+epinephrine group while the lowest belonged to the PDL group (80% vs. 27%).The mean period of remission in the 5-FU+epinephrine group was significantly longer in comparison to the two other groups. (P<0.001) In photographic evaluation, the best response was observed in the 5- FU+epinephrine group.Conclusion: 5-FU+epinephrine is a cheap option which can provide a rapid response and long remission .With respect to limited effectiveness, short remission and high cost; PDL dose not seem to be a preferred choice in the treatment of psoriasis.
Iranian Journal of Dermatology
Iranian Society of Dermatology
2717-0721
12
v.
2
no.
2009
36
41
https://www.iranjd.ir/article_101318_4b12914b037bd74df958d069abff5cba.pdf
A Unique Albino Village of Bhatti Tribe in Rural Sindh, Pakistan, with Oculocutaneous albinism Manifestations: An Epidemiological Study
Azam
Jah Samdani
author
Bahram
Khan Khoso
author
text
article
2009
eng
Background: Oculocutaneous albinism is a disease with an autosomal recessive inheritance pattern in most cases. People with Oculocutaneous albinism face many health, psychological and financial issues. In this study, we report a unique village of Bhatti tribe in Jacobabad District, Pakistan, in which 40 children and adults with albinism live. The aim of this study was to observe the pattern of inheritance, complications and socioeconomic impacts of this condition on the community.Methods: Detailed clinical history and relevant data were recorded on a specially designed performa followed by clinical examination by a consultant dermatologist together with his team to observe the extent of the disease and associated complications in two seasons (winter and summer).Result: This village, with a total population of 810, had 40 cases, 17 male and 23 female, ranging in age from 6 months to 35 years. About 65% of the affected individuals were younger than 16 years of age. There were 22 involved families in this village and 2 of them had 3 or 4 affected members. In this area, which is geographically close to the equator, all 40 cases (100%) had photodermatosis and 36/40 cases (90%) had bacterial skin infections during summer. In addition, they had limited outdoor exposure during this season. These complications also caused occupational, social and educational limitations 9 months a year. Eye problems were present in all 40 cases; however, all 40 cases were malignancy free.Conclusion: Oculocutaneous albinism is challenging not only because of its management but also because of its social and financial impacts. The current trend of consanguineous marriages, prevalent in this village, puts further emphasis on the role and the importance of marriage counseling in such situations.
Iranian Journal of Dermatology
Iranian Society of Dermatology
2717-0721
12
v.
2
no.
2009
42
46
https://www.iranjd.ir/article_101319_f1517fca34e8603f05897f35c93e6c5d.pdf
Skin Infections among Type II Diabetic Patients in Faisalabad Region, Pakistan
Fatma
Hussain
author
Muhammad
Arif Mann
author
Munir
Ahmed
author
text
article
2009
eng
Background: Endocrine disorders occasionally manifest themselves by their associated or induced cutaneous abnormalities. Skin is a frequently overlooked source of pathology. Several cutaneous abnormalities are more prevalent in diabetes mellitus. The purpose of the study was to evaluate the frequency of skin infections among type 2 diabetic patients and associated risk factors in Faisalabad, PakistanMethods: Type 2 diabetic patients (disease duration >1 year) and healthy volunteers were recruited and skin infections were assessed.Results: Diabetes related skin infections were detected in 43% of type 2 diabetic patients and in 22.5% of the control subjects. Onychomychosis, candida vaginitis and herpes simplex were identified in 9.2 % of the diabetic patients compared to 2.5% of the control subjects. Skin infections had an insignificant association with sex, mean age, age at diabetes diagnosis, diabetes duration, secondary complications of diabetes, blood glucose and cumulative haemoglobin.Conclusion: A broad spectrum of cutaneous disorders was seen in type 2 patients. While the pathogenesis of the most of the skin lesions remains ambiguous, additional studies should be performed to determine whether skin lesions could be used for predicting imminent diabetic complications.
Iranian Journal of Dermatology
Iranian Society of Dermatology
2717-0721
12
v.
2
no.
2009
47
51
https://www.iranjd.ir/article_101321_504841885e12946165c7fd7d44ea53b0.pdf
Polymerase Chain Reaction Study of Anogenital Condylomas for High Risk HPV Types
Soheila
Nassiri
author
Mojdeh
Sarlak
author
Farahnaz
Bidari Zereh Posh
author
Siamak
Mirab Samiee
author
Farzaneh(Batool)
Rahimi
author
Mehdi
Qaisari
author
text
article
2009
eng
Background: Anogenital wart is a common sexually transmitted disease affecting both genders. The aim of this study was to evaluate human papilloma virus types of anogenital warts with Polymerase Chain Reaction (PCR). Method: 65 formalin fixed paraffin embedded (FFPE) tissue blocks of the anogenital warts obtained from the pathology lab of Loghman Hakim hospital were included in this study. Results: In 27 samples (41.5%), human papilloma virus was detected by PCR. In addition, low risk HPV types (6, 11) were identified in all samples without any positivity for high risk HPV types (16, 18, 31 and 33). Conclusion: By finding low risk HPV types in all samples, it could be concluded that Anogenital warts seems not to be precursors of anogenital malignancies.
Iranian Journal of Dermatology
Iranian Society of Dermatology
2717-0721
12
v.
2
no.
2009
52
55
https://www.iranjd.ir/article_98565_88470f825864a94357bbf8f0a3f70d82.pdf
Interplay among Antioxidants and Oxidants in Psoriasis
Soheila
Nassiri
author
Farhad
Malekzad
author
Mojdeh
Sarlak
author
Marjan
Saeedi
author
Mehdi
Hedayati
author
Mehdi
Qaisari
author
text
article
2009
eng
Background: The etiology of psoriasis, a chronic inflammatory skin disease, has not been elucidated. However, Oxidant / antioxidant imbalance is suspected.The aim of this study was to evaluate oxidant / antioxidant status in psoriatic patients.Method: forty two psoriatic patients and 42 age and sex matched controls were recruited for this study. Serum total antioxidant capacity (TAC), oxidized light density lipoprotein (Ox-LDL) and malondialdehyde (MDA) levels were determined.Results: A statistically significant increase in the serum level of MDA was found between patients and controls. No significant difference was found in the serum levels of other parameters in the two groups.Conclusion: Our results supported the hypothesis of an imbalance between oxidants and antioxidants in psoriasis and pointed to the probability of an increased risk of cardiovascular diseases in psoriatic patients.
Iranian Journal of Dermatology
Iranian Society of Dermatology
2717-0721
12
v.
2
no.
2009
56
59
https://www.iranjd.ir/article_101322_396d1e296d4450bac569f5cf91484e81.pdf
A Randomized Comparative Study Between Three Times And Five Times Weekly Phototherapy With NBUVB For Treating Chronic Plaque Type Psoriasis
Hallaji
Zahra
author
Ehsani
Amir Houshang
author
Noormohammadopoor
Pedram
author
Mansouri
Parham
author
text
article
2009
eng
Background: Psoriasis is a chronic inflammatory skin disease that is estimated to affect 0.6% to 4.8% of the general population. The optimum number of NB-UVB phototherapy sessions is yet to be determined. The aim of this study was to compare therapeutic effects of NB-UVB in treating chronic plaque type psoriasis three times weekly vs. five times weekly. Materials and Methods: This study was designed as a single-blinded randomized controlled trial. Patients with chronic plaque type psoriasis who were candidates for phototherapy were randomized in two groups, one group received NB-UVB three times a week (group A) while the other group received the same treatment five times a week (group B) . Patients’ PASI score was determined before commencing the study and after 12 weeks of treatment. At the end of the study, response rate, PASI score of patients and total dose of UVB per patient were determined. Results: A total of 47 patients were enrolled. Thirty two patients (19 in group A, 13 in group B) completed the study. Total response rate was 71.9% after 12 weeks of treatment (23 out of 32 patients) while nine patients (28.1%) had no response. Response rate was 78.9 % (15 out of 19) in group A Vs. 61.5% (8 out of 13 patients) in group B (p>0.05). Total UVB dose received, treatment sessions, erythema and final PASI score was lower in group A (p>0.05). Conclusion: With similar therapeutic effects, it seems that three times a week regimen may be superior to five times a week for its lower total UVB dose received and higher safety profile.
Iranian Journal of Dermatology
Iranian Society of Dermatology
2717-0721
12
v.
2
no.
2009
60
63
https://www.iranjd.ir/article_98566_4b813c8a4f5e01e3062433377ffb2570.pdf
An Adult Case of Hydroa Vacciniforme
Reza Mahmoud
Robati
author
Marjan
Saeedi
author
Nima
Sarrafi-rad
author
text
article
2009
eng
Hydroa vacciniforme (HV) is a rare acquired photodermatosis, usually with onset in childhood and characterized by vesicles, crust and scar formation that follow exposure to sunlight.Vacciniform scars of face and dorsa of the hands are common features but oral ulcer and eye signs also rarely occur. It usually resolves before adult age. A rare manifestation of the disease would be persistence until adult age which is presented in this report.
Iranian Journal of Dermatology
Iranian Society of Dermatology
2717-0721
12
v.
2
no.
2009
64
66
https://www.iranjd.ir/article_101323_bdc6981601dc9f89b6f13903c8ea2053.pdf
Acquired Unilateral Nevoid Telangiectasia Syndrome: A Case Report and Review of Literature
Saeed
Amini
author
Ali Akbar
Akaberi
author
Fariba
Binesh
author
text
article
2009
eng
Unilateral nevoid telangiectasia syndrome (UNTS) can be classified into two major categories: congenital and acquired. There have been reports showing an increase in skin estrogen and progesterone receptors in patients with this syndrome. We report a male patient with acquired unilateral nevoid telangiectasia syndrome without any associated physiological or pathological conditions.
Iranian Journal of Dermatology
Iranian Society of Dermatology
2717-0721
12
v.
2
no.
2009
67
68
https://www.iranjd.ir/article_101324_5a54cfead03020d3d26c07644ce39e33.pdf
Acne Keloidalis Nuchae in a White Woman
Kafaie
Parichehr
author
Akaberi
Ali Akbar
author
Hajihoseini
Hosein
author
Binesh
Fariba
author
text
article
2009
eng
Acne keloidalis is a chronic inflammatory process that involves hair follicles of the nape of the neck and leads to hypertrophic scarring. In all references, it is noticed that this process occurs only in males after puberty and is especially seen in the black race. In this case, we report a 31-year-old white woman who had hypertrophic papules in the nape of her neck since 10 years ago and in pathological examination, the diagnosis of acne keloidalis was confirmed.
Iranian Journal of Dermatology
Iranian Society of Dermatology
2717-0721
12
v.
2
no.
2009
69
70
https://www.iranjd.ir/article_98567_87a07cb706699dab43b5f338592c5096.pdf
CASE: Erosive Nodule on the Vulval Skin
Soheila
Nassiri
author
Marjan
Saeedi
author
Sima
Kavand
author
Nastaran
Namazy
author
Afsaneh
Maarefat
author
text
article
2009
eng
A 64-year-old Iranian woman presented with a genital erosive skin lesion that she had noticed from two years ago. On physical examination, a 20 to 25 millimeter purplish lesion was observed on the vulval skin (Figure 1). The indurated lesion showed a small central erosion measuring 3 to 5 mm. Inguinal lymph nodules were not palpable. A skin biopsy specimen was obtained from the eroded lesion (Figure 2).
Â
Iranian Journal of Dermatology
Iranian Society of Dermatology
2717-0721
12
v.
2
no.
2009
71
72
https://www.iranjd.ir/article_101325_c3567b102672e3317d090651018c2a2b.pdf
No Dermatological Manifestation in Reported Cases of Human H5N1 Infection
Viroj
Wiwanitkit
author
text
article
2009
eng
Dermatological manifestations can be seen in many infectious diseases which can serve as diagnostic clues for such disorders. In dermatology, studying the dermatological manifestations of new emerging infectious diseases can be useful in clinical practice. For example, studying the dermatological manifestations of human immunodeficiency virus infection (HIV) in its early emerging period yielded several useful clinical data that is still helpful in cases infected with HIV. Bird flu (H5N1 influenza virus infection) is a new emerging infectious disease. It has recently been documented in medical literature for only a few years. Our knowledge on the dermatological manifestations of the bird flu is limited. It is an interesting topic to assess and summarize data regarding the dermatological manifestations of the bird flu. The author hereby performed a retrospective study to answer this research question. This brief study was a retrospective research which was done through review of the available literature. In this study, the author reviewed reports concerning human bird flu infection from Thailand available in Index Medicus and Science Citation Index. The author also reviewed published papers in all 256 local Thai journals which are not indexed in international databases. The reports that contained incomplete data were excluded for further analysis. The focus of attention in each paper was the reported dermatological manifestations due to the bird flu infection. Summarization of all determined findings was performed using the basic descriptive statistical analysis. According to this retrospective study, there were 6 included reports on 12 indexed cases1,5. Based to the literature, there was no dermatological manifestation in the reported cases of human H5N1 infection. The prevalence rate of dermatological manifestations in the bird flu infected cases in this study was equal to 0 %. Naturally, H5N1 virus is a kind of influenza virus. In dermatology, human influenza virus may have some dermatological manifestations6. However, the author found no report or evidence regarding the dermatological manifestations of bird flu in reviewed cases. This might imply that dermatological manifestations are not of clinical importance in bird flu based on case series from Thailand. Finally, the author proposes that there might be no dermatological manifestation in human H5N1 infection.
Iranian Journal of Dermatology
Iranian Society of Dermatology
2717-0721
12
v.
2
no.
2009
73
73
https://www.iranjd.ir/article_101326_7625b4da34d470546da2c619b3882406.pdf