%0 Journal Article %T Does Prolactin Indicate Severity of Psoriasis? %J Iranian Journal of Dermatology %I Iranian Society of Dermatology %Z 2717-0721 %A Maryam, Azizzadeh %A Mojtaba, Malek %A Mehdi, Amiri %A Raheb, Ghorbani %D 2009 %\ 10/01/2009 %V 12 %N 3 %P 79-81 %! Does Prolactin Indicate Severity of Psoriasis? %K Psoriasis %K prolactin %K severity %R %X Background: Psoriasis vulgaris is a common chronic and inflammatory disease of skin that its etiology is not completely known. However, it seems that genetic and environmental factors play a role in this disease. In vitro studies show that prolactin as a neurohormone has an etiologic effect on psoriasis. This study aimed to compare serum prolactin levels in psoriatic patients with control group. Method: Prolactin level in serum was measured with ELISA method in 30 patients with psoriasis vulgaris and in 30 healthy persons as control group, which they had been matched with a view to age and sex. Result: Mean serum prolactin level in psoriatic patients was not significantly higher than control group. However, there was statistically significant relation between severity of disease and serum prolactin levels (r= 0.521, p=0.003). Conclusion: Positive relation between severity of psoriasis vulgaris and serum prolactin levels may suggest that prolactin is an index that shows severity of disease. %U https://www.iranjd.ir/article_98084_5e123c9f6134c64b205564328fd35b71.pdf