%0 Journal Article %T Langerhans cell Histiocytosis: Report of a case with cutaneous lesions with favorable response to oral Thalidomide %J Iranian Journal of Dermatology %I Iranian Society of Dermatology %Z 2717-0721 %A Mortazavi, H %A Ehsani, AH %A Safaei Naraghi, Z %A Asgari, M %D 2001 %\ 07/01/2001 %V 4 %N 4 %P 34-40 %! Langerhans cell Histiocytosis: Report of a case with cutaneous lesions with favorable response to oral Thalidomide %K langerhans cell histiocytosis %K Thalidomide %K Birbeck granule %R %X We report of a 29-year-old man presented with yellow-red, scaling papules on the skin of scalp, retro-auricular folds, inguinal, axillary, chest and abdomen. The lesions had a poikilodermatious appearance in some areas, such as trunk. The patient also had diabetes insipidus and skull osteolytic lesions. The diagnosis of langerhans cell histiocytosis (LCH) was suggested based on H and E staining of skin biopsy specimen. S-100 staining was positive in immunohistochemistry. Birbeck granules were seen in electron microscopic examination confirming the diagnosis of LCH. Considering the systemic involvement, he is a case of an extensive LCH in new classification and a case of Hand-Schuller-Christian in the old classification. The cutaneous lesions of the patients responded to oral thalidomide 200 mg daily after 2 months and did not recur after 6 months follow up. %U https://www.iranjd.ir/article_98436_ad805c5f91943222eb703fa5813ce22c.pdf