ORIGINAL_ARTICLE
Evaluation of the antioxidant defense status in psoriasis
Background: Psoriasis is a chronic inflammatory disease of theskin. The etiology of psoriasis is not known exactly. Recently, ithas been suggested that an imbalance in the oxidant- antioxidantstatus due to an increased reactive oxygen species production and/or deficient function of the antioxidant system may be involvedin the pathogenesis of psoriasis. The aim of this study was toevaluate the antioxidant defense status in patients with psoriasisand to look for a correlation, if any, between the antioxidantdefense status and the severity of psoriasis.Method: Sixty patients with psoriasis and an equal number ofage and sex matched healthy controls were enrolled in the study.Plasma levels of malondialdehyde (MDA), reduced glutathione(GSH), and superoxide dismutase (SOD), and antioxidant potential(AOP) were measured in cases as well as controls.Result: Patients with psoriasis were found to have significantlyhigher levels of plasma SOD (P < 0.001) and MDA (P < 0.001)and lower levels of GSH (P < 0.001) than controls. Plasma AOPwas not significantly different between patients and controls(P= 0.822).Conclusion: The results of our study support the hypothesisof an imbalance in the oxidant –antioxidant status in psoriasis,which could contribute to the pathogenesis of psoriasis.
https://www.iranjd.ir/article_98233_6e1e1b107935b647871d6a6b21489628.pdf
2014-10-01
117
121
antioxidant potential
Malondialdehyde
Psoriasis
reduced glutathione
Superoxide dismutase
Hussain
Sajjad
1
AUTHOR
Hassan
Iffat
2
LEAD_AUTHOR
Majeed
Sabiya
3
AUTHOR
Showkat A
Bhat
4
AUTHOR
Hinah
Altaf
5
AUTHOR
Peerzada
Sajad
6
AUTHOR
ORIGINAL_ARTICLE
Association of pityriasis rosea with Human Herpesvirus-6
Background: Pityriasis rosea (PR) is a common papulosquamousskin disorder that is suspected to have an infectious etiology.We aimed to study the role of human herpesvirus-6 (HHV-6) inthe pathogenesis of PR.Method: We used immunohistochemical (IHC) assays to detectHHV-6 in patients with PR. Fifty-one patients with PR and 35 ageand sex matched healthy control samples were enrolled in thestudy. The intensity and percentage of cell staining for HHV-6infection were evaluated and recorded.Result: The intensity of IHC staining was negative in 25 (49.01%)patients and 24 (68.58%) control samples while it was +1 in 6(11.77%) patients and 11 (31.42%) control samples, +2 in 4 (7.85%)patients and +3 in 16 (31.37%) of them. The incidence of moderateand intense staining for HHV-6 was significantly higher amongpatients with PR than the control group (P value < 0.01).Conclusion: We concluded that HHV-6 infection may play arole in some patients with PR. The rate of HHV-6 infection wassignificantly higher in PR patients than the control group.
https://www.iranjd.ir/article_98234_21a73e68c9ef5ca1e78087a652e9a08d.pdf
2014-10-01
122
125
human herpes virus
6 (HHV
6)
immunohistochemistry
pityriasis rosea
Banihashemi
Mahnaz
1
AUTHOR
Javidi
Zari
2
AUTHOR
Khani
Fatemeh
3
AUTHOR
Ghiasi-Moghadam
Taghi
4
AUTHOR
Ghaffarzadegan
Kamran
5
AUTHOR
Hashemzadeh
Sara
6
LEAD_AUTHOR
ORIGINAL_ARTICLE
Tzanck smears in herpes simplex virus infections
Background: The diagnosis of herpes simplex virus may requirevirological confirmation. Tzanck smear is an old, rapid, costeffective but nonspecific method that has been recently re-evaluatedas a method for the diagnosis of herpes virus infection. This studywas conducted to compare Tzanck smear and viral culture in thediagnosis of herpes simplex virus infection in patients clinicallysuspected to be infected with this virus.Method: Materials obtained from a fresh vesicle were used toprepare Tzanck smears and viral cultures.Result: In this study, 40 (71.4%) of the 56 samples were culturepositive while Tzanck smears were positive in 36 (64.3%) patients.We found that the sensitivity and specificity of the Tzanck testwas 90% and 100% respectively when compared to cell culture.Moreover, the positive predictive value (PPV) and negativepredictive value (NPV) of the Tzanck test was 100% and 80%,respectively.Conclusion: The Tzanck smear has its limitations but is still asuitable rapid, easy, and cost effective diagnostic method forherpes simplex virus infections, especially when viral cultureor other virological methods are not available.
https://www.iranjd.ir/article_98235_260f476394c2a265f5fe2f0b15d2a9a6.pdf
2014-10-01
126
129
culture
Diagnosis
herpes simplex virus
Tzanck smear
Banihashemi
Mahnaz
1
AUTHOR
Pezeshkpoor
Fakhrozaman
2
AUTHOR
Hadis
Yousefzadeh
yousefzadehh901@mums.ac.ir
3
LEAD_AUTHOR
Fatemeh
Livani
4
AUTHOR
Gholamreza
Ghandeharian
5
AUTHOR
ORIGINAL_ARTICLE
High frequency of genital involvement in lichen planus: a cross sectional study
Background: Lichen planus is a chronic inflammatory disease ofunknown etiology that may involve mucocutaneous tissues. Themain aim of our study was to evaluate the frequency of oral andgenital lichen planus in men and women affected by skin lesions.Method: A total of 132 patients with clinical and histopathologicaldiagnosis of lichen planus were evaluated for oral and genitalinvolvement. All data was analyzed by SPSS version 19. Chisquare test and t-test were used for statistical analysis.Result: Of 132 patients enrolled in this study, 72 were men and60 were women. Genital and oral lichen planus
https://www.iranjd.ir/article_98236_41883fef9aedb22ec717615d331819a3.pdf
2014-10-01
130
133
Genital
Lichen Planus
Mucous Membrane
oral
Ebrahimzadeh
Mohammad
1
AUTHOR
Dehghani
Farideh
2
LEAD_AUTHOR
Amirniroumand
Niloofar
3
AUTHOR
ORIGINAL_ARTICLE
Debaryomyces hansenii colonization and its protein profile in psoriasis
Background: Psoriasis is an immune mediated skin disorderwhich is mainly characterized by abnormal proliferation anddifferentiation of keratinocytes. It is believed that Debaryomyceshansenii (Candida famata) can colonize skin and mucous membranesof psoriatic patients and exacerbate psoriatic lesions via toxins,antigens, and proteins. The aims of this study were to evaluateDebaryomyces hansenii colonization and its protein profile inpsoriatic patients.Method: Fifty-one patients with psoriasis vulgaris and 51 healthyindividuals were enrolled in the study. Skin and oral specimensfrom all participants were cultured on the CHROMagar Candidamedium. Isolated yeast like fungi were identified using thesequence of the D1/D2 domain of the 26S rRNA gene. Debaryomyceshansenii proteins were analyzed using Sodium Dodecyl Sulphate-Polyacrylamide gel electrophoresis.Result: Debaryomyces hansenii was only isolated from the oralcavity of 7.84% of the patients. The extracts obtained from variousDebaryomyces hansenii isolates had 45 protein bands, which rangedfrom 18 to >180 kDa. Secretory proteins were seen only in twoisolates, which ranged from 35 to100 kDa.Conclusion: Debaryomyces hansenii can colonize oral cavity ofpatients with psoriasis. In addition, various Debaryomyces hanseniiisolates have different somatic proteins, which may have a rolein provocation and exacerbation of psoriasis.
https://www.iranjd.ir/article_98237_0e35158c9ba8eea922aaa07670218b07.pdf
2014-10-01
134
137
Candida
Debaryomyces hansenii
Sarvtin
Mehdi Taheri
1
LEAD_AUTHOR
Hedayati
Mohammad Taghi
2
AUTHOR
Abastabar
Mahdi
3
AUTHOR
Shokohi
Tahereh
4
AUTHOR
ORIGINAL_ARTICLE
A young man with multiple reddish papules and nodules on the trunk and extremities
A 23-year old man was presented with multiple papules andnodules (25 lesions) on the trunk and proximal extremities(Figure 1). Two or three lesions were appeared at childhood andincreased to 25 lesions in early adulthood. There were variationsin size from several millimeters to 2 cm with spontaneous andinducible pain especially in exposure to the cold environment.Same lesions were present in his brother, aunt and uncle. Weperformed biopsy from one of the lesions on the trunk.
https://www.iranjd.ir/article_98238_b0064dbc5a1f9a15a2013dd021e9f3e4.pdf
2014-10-01
138
140
Eftekhari
Hojat
1
LEAD_AUTHOR
Nafezi
Reza
2
AUTHOR
ORIGINAL_ARTICLE
The role of multidisciplinary team meetings in optimal management of complex dermatology: a novel concept?
We would like to draw the attention of thedermatological fraternity to the concept ofmultidisciplinary team meetings. This concept,although novel in dermatology, has been in voguefor optimal oncological management in variouspremier cancer set-ups worldwide. MultidisciplinaryTeam Meetings (MDTs) or tumour boards are agroup of dedicated personnel aimed at optimisingthe management of cancer patients in an integratedmanner, so as to standardize care, to ensure timelyand appropriate attention from skilled professionals,and to enable patients to receive the best levels ofmanagement in a consistent manner. The teamusually comprises surgeons, oncologists, radiologists,pathologists, nurses, and an MDT co-ordinator.
https://www.iranjd.ir/article_98239_190780c6820ae349028d8c093cfa3cc2.pdf
2014-10-01
141
141
Aggarwal
Priyanka
1
LEAD_AUTHOR
Sharma
Yugal Kishore
2
AUTHOR
ORIGINAL_ARTICLE
Clinicopathologic evaluation of 100 skin biopsies in Afzalipour Hospital, Kerman, Iran
Skin biopsy is an essential investigation fordermatologists. The technique used to obtain aspecimen for microscopic evaluation and mayhave a significant impact on the ability of the
https://www.iranjd.ir/article_98240_747317d2cda4a5a628f63a1123bda7bc.pdf
2014-10-01
142
143
Meymandi
Simin Shamsi
1
AUTHOR
Shanehsaz
Siavash Mohammadzadeh
2
LEAD_AUTHOR
Badakhsh
Hoda
3
AUTHOR
Fadaei
Fahameh
4
AUTHOR
ORIGINAL_ARTICLE
Kaposi’s varicelliform eruption: a case report
Kaposi’s varicelliform eruption (KVE) is a typeof skin disorder caused mainly byherpes simplex virus (HSV) type 1 and2 and occasionally by coxsackie A 16 and vacciniavirus, which is commonly found in the second andthird decades of life. It is predominantly associatedwith atopic dermatoses. Therefore, it is also termedeczema herpeticum (EH) 1. Herein, we report acase of Kaposi’s varicelliform eruption triggeredby HSV infection.
https://www.iranjd.ir/article_98241_024df4b92546ff0ecbc8c733c0580455.pdf
2014-10-01
144
145
Paik
Sabyasachi
1
LEAD_AUTHOR
Pal
Agnik
2
AUTHOR
Sukanta
Sen
drsukant@gmail.com
3
AUTHOR
Gautam
Banerjee
4
AUTHOR
Santanu
Tripathi
5
AUTHOR
ORIGINAL_ARTICLE
Aplasia cutis congenita
The patient was a female neonate bornprematurely at 36 weeks of gestation by a Cesareansection. During pregnancy, the mother had nohistory of fever, drug use, or X-ray exposure.The mother was gravida 2 and had no history ofabortion. Her first child was healthy. There wasno record of birth trauma. The perinatal historywas negative for intrauterine trauma, the use ofantithyroid medication, or misoprostol.
https://www.iranjd.ir/article_98242_14de7191cf57b5003110849fc0a6e170.pdf
2014-10-01
146
147
Pourarian
Shahnaz
1
AUTHOR
Borghei
Seyed Amirmasoud
2
LEAD_AUTHOR
Azizi
Mahba
3
AUTHOR