ORIGINAL_ARTICLE
Efficacy and tolerability of adapalene 0.1%-benzoyl peroxide 2.5% combination gel in treatment of acne vulgaris in Indian patients: A randomized investigator-blind controlled trial
Background: Topical retinoid based combinations are recommended to enhance the outcome of acne treatment. Adapalene-benzoyl peroxide (BPO) combination gel was approved in 2009 for acne treatment. The aim of this study was to evaluate the efficacy and tolerability of adapalene 0.1%-benzoyl peroxide 2.5% combination gel compared to adapalene 0.1% gel monotherapy and benzoyl peroxide 2.5% gel monotherapy in treatment of acne vulgaris in Indian patients.Methods: A randomized, parallel group, investigator-blind clinical trial was conducted from September 2014 to September 2015 in the Dermatology outpatient department. The patients were randomized into three groups of adapalene 0.1% gel, benzoyl peroxide 2.5% gel, and adapalene 0.1%-benzoyl peroxide 2.5% combination gel. The patients were asked to apply the allocated gel to the face in the evening for 12 weeks. Efficacy was evaluated using percent of reduction in total, inflammatory, and non-inflammatory lesions and success rate while tolerability was assessed by evaluating skin dryness, erythema, stinging or burning sensation and scaling at baseline and 1, 2, 4, 8, and 12 weeks.Results: At the end of 12 weeks, the success rate reached 37.2% with adapalene-BPO combination gel compared to 23.3% and 19.4% for adapalene and benzoyl peroxide gel monotherapy respectively. Adapalene-BPO combination gel was significantly effective in the reduction of total, non-inflammatory and inflammatory lesions by 75.9%, 75.4%, and 74.7% respectively compared to the corresponding monotherapies. Side effects with adapalene–BPO combination gel were mild and transient.Conclusion: Adapalene–BPO combination gel was more efficacious and better tolerated than adapalene and benzoyl peroxide gel monotherapy.
https://www.iranjd.ir/article_98294_463ff1aa98dfc764bca9de1ba4162c17.pdf
2016-10-01
105
112
Acne Vulgaris
adapalene
Benzoyl peroxide
treatment
Jawade
Sugat A.
1
LEAD_AUTHOR
Saigaonkar
Vaidehi A.
2
AUTHOR
Kondalkar
Ambika R.
3
AUTHOR
ORIGINAL_ARTICLE
Quality of life in patients with psoriasis: A cross-sectional study in a dermatology referral hospital in Tehran, Iran
Background: Psoriasis is a chronic skin disorder that can significantly affect a patient’s quality of life (QoL). The goal of this study was to determine the QoL in patients with psoriasis and to investigate the correlation between the QoL, demographic data, and clinical severity of psoriasis.Methods: This prospective, cross-sectional study was conducted from April 2014 to January 2015. One hundred patients with plaque type psoriasis from the Phototherapy Clinic of Razi Hospital, Tehran, Iran were selected and asked to complete questionnaires. The Psoriasis Area Severity Index (PASI) to measure the severity of psoriasis, and the Dermatology Life Quality Index (DLQI) was used for the assessment of the quality of life.Results: The total DLQI score of the all participants was between 0 and 29 with a mean score of 10.6 ± 6.4. The DLQI scores ranged from “very large” to “extremely large” in 45% of the patients. The mean score was 9.2 ± 6.6 in the male group and 12.1 ± 5.9 in the female group, which showed a statically significant difference (P=0.02). Other variables associated with an impaired QoL were age (P=0.002) and PASI (P=0.01). The impact on QoL was higher in younger patients, and in patients with higher PASI scores.Conclusion: In conclusion, although psoriasis is a benign disorder, this study confirms our initial hypothesis that psoriasis significantly impairs the QoL, which is more pronounced in younger patients, women, and patients with a more severe disease (higher PASI scores).
https://www.iranjd.ir/article_98295_157545a54c8465366a20e83a6a97e144.pdf
2016-10-01
113
118
Psoriasis
Quality of Life
DLQI
PASI
Abedini
Robabeh
1
AUTHOR
Lajevardi
Vahideh
2
AUTHOR
Hallaji
Zahra
3
AUTHOR
Khodashenas
Zohre
4
AUTHOR
Zafar
Fatemeh
5
AUTHOR
Nasimi
Maryam
6
LEAD_AUTHOR
ORIGINAL_ARTICLE
Serum vascular endothelial growth factor in Iranian patients with moderate-severe psoriasis before and after treatment: a PASI-75 response as a practical treatment goal
Background: Psoriasis is a chronic disease with multiple biochemical and vascular abnormalities. Several studies have evaluated circulating levels of vascular endothelial growth factor (VEGF) in psoriasis, but none of them evaluated it after reaching a PASI-75 response, as a practical treatment goal. The aim of this study was to evaluate serum levels of VEGF in moderate to severe psoriatic patients before and after treatment compared with healthy controls.Methods: This study was approved by the Ethics Committee of Shahid Beheshti University of Medical Sciences. Fifty-eight patients with moderate- severe psoriasis and 60 age-and gender-matched healthy controls were recruited to this study. Serum VEGF levels (pg/ml) of both groups were measured. We used Psoriasis Area and Severity Index (PASI) scoring to assess disease activity in patients. According to the disease severity, the patients received proper treatment. When they reached a PASI-75 response, serum VEGF levels were measured once more.Results: In our study, the median serum VEGF level was significantly higher in psoriatic patients (before and after treatment) as compared to healthy controls. Moreover, patients showed a significant reduction in their serum VEGF levels after reaching PASI-75. The median time of therapeutic effect (reaching a PASI- 75 response) was four months. Furthermore, our study showed a significant correlation between the serum VEGF level and age, BMI, PASI, and disease duration (P
https://www.iranjd.ir/article_98296_037c1b13ee703db712efcdaaf353ed64.pdf
2016-10-01
119
124
serum vascular endothelial growth factor
PASI 75 response
Psoriasis
treatment
Shahidi-Dadras
Mohammad
1
AUTHOR
Abdollahimajd
Fahimeh
2
LEAD_AUTHOR
Younespour
Shima
3
AUTHOR
Nikvar
Mohammad
4
AUTHOR
ORIGINAL_ARTICLE
Serum leptin levels in psoriatic patients with non-alcoholic fatty liver disease
Background: The prevalence of non-alcoholic fatty liver disease is higher in patients with psoriasis than in the normal population. Serum leptin levels are higher in patients with psoriasis and in patients with non-alcoholic fatty liver. The purpose of this study was to determine the serum levels of leptin in psoriatic patients with and without non-alcoholic fatty liver.Methods: This cross-sectional study was conducted at Razi Dermatology Hospital, Tehran, Iran in 2013. A total of 50 patients with psoriasis were enrolled in the study. Fatty liver grade was assessed via ultrasonography and serum leptin levels were measured using the ELISA method.Results: Ten patients had normal livers and 40 had fatty livers with different grades. The median serum leptin level was significantly higher in psoriatic patients with fatty liver (11.75ng/mL) in comparison to those without fatty liver (2.80 ng/ml). Moreover, there was a direct correlation between the leptin level and the grade of fatty liver.Conclusion: serum leptin can be elevated in the course of psoriasis and may have a role in the pathogenesis of non-alcoholic fatty liver disease and other metabolic co morbidities in psoriatic patients.
https://www.iranjd.ir/article_99441_736b8c98e513b3012077ba740076267b.pdf
2016-10-01
125
130
Psoriasis
non-alcoholic fatty liver
leptin
Zahra
Hallaji
1
AUTHOR
Vahideh
Lajevardi
2
AUTHOR
Robabeh
Abedini
3
LEAD_AUTHOR
Amir
Soleymani
4
AUTHOR
Azadeh
Goodarzi
azadeh_goodarzi1984@yahoo.com
5
AUTHOR
Mehrnaz
Salehi-Taleghani
6
AUTHOR
Sara
Beygi
7
AUTHOR
ORIGINAL_ARTICLE
Genital dermatoses in circumcised men: A cross-sectional study from Mashhad, Iran
Background: Knowledge of the frequency and distribution of dermatoses in the male genital area and the effect of circumcision on these two factors are helpful guides to a correct diagnosis. The aim of this study was to determine the prevalence of genital dermatoses in circumcised men.Methods: This cross-sectional study was done on all circumcised men complaining about skin lesions in their genital area. Results: Overall, 355 men with skin lesions in their genital area were enrolled in this study. All of them were circumcised for religious reasons. The mean age of the patients was 31.4±11.5 years. Most skin lesions were seen in the age group 20-29 years (152 cases, 42%). Genital warts were the most common disease (60 cases, 16.9%) followed by dermatitis (38 cases, 10.7%), lichen planus (36 cases, 10.1%), and scabies (36 cases, 10.1%). The most common site for genital lesions was the penile shaft (155 cases, 43.7%). Genital warts were more common on the pubic area, penile shaft, and penoscrotal and peno-pubic junction. We did not observe any cases of balanitis in our study.Conclusions: Genital warts were the most common disease among our cases. Inflammatory dermatoses such as psoriasis and balanitis were less common in our population comparedwith other studies.
https://www.iranjd.ir/article_98297_baa7fcbf4c669b80d9407d617a4175e6.pdf
2016-10-01
131
135
circumcision
dermatoses
male genitalia
Yazdanpanah
Mohammad Javad
1
AUTHOR
Ahmadnia
Hassan
2
LEAD_AUTHOR
Livani
Fatemeh
3
AUTHOR
Shargi
Mohammad Reza
4
AUTHOR
Vosoughi
Elham
5
AUTHOR
Rahmani
Shahram
6
AUTHOR
Shakeri
Mohammad Taghi
7
AUTHOR
ORIGINAL_ARTICLE
Generalized granuloma annulare in association with breast carcinoma
The association of granuloma annulare and some neoplasms is controversial. However, there is an increase in the number of case reports and relevant studies supporting the conceptof granuloma annulare being associated with certain types of hematologic neoplasms and solid tumors.Herein, we describe a 54-year-old woman with a 20-month history of generalized annular lesions that did not respond to conventional treatment and was followed by breast cancer. Only two cases of granuloma annulare and breast cancer have been reported so far in the literature. We believe that these cases emphasize on considering granuloma annulare as a possible paraneoplastic dermatoses.
https://www.iranjd.ir/article_98293_8c5ee8e05dc8a8b1929ac9c138828b80.pdf
2016-10-01
136
138
breast cancer
granuloma annulare
neoplasm
Banihashemi
Mahnaz
1
AUTHOR
Mohammad Javad
Yazdanpanah
yazdanpanahmj@mums.ac.ir
2
AUTHOR
Soleiman
Nouri
3
AUTHOR
Sarah
Hashemzadeh
4
LEAD_AUTHOR
ORIGINAL_ARTICLE
Harlequin ichthyosis: A case report from Iran
Harlequin ichthyosis is a rare and exceedingly severe form of congenital ichthyosis with an incidence of approximately 1 in 300,000 births. These patients are at a high risk for neonatalinfection and septicemia. Most affected infants die within the first days or weeks of life.We report a male baby born with harlequin ichthyosis. There is limited information regarding the course and prognosis of neonates affected with harlequin ichthyosis. However, it is now evident that these infants, depending on the severity, may have an extended survival potential with intensive supportive measures as well as the addition of retinoids.
https://www.iranjd.ir/article_99442_33e37c35db4e6a1d05baf5a99ed5c2aa.pdf
2016-10-01
139
141
Ichthyosis
harlequin ichthyois
Retinoid
Simin
S. Meymandi
1
AUTHOR
Niloofar
Mehrolhasani
2
LEAD_AUTHOR
Marcie
Ulmer
3
AUTHOR
Richard
I. Crawford
4
AUTHOR
ORIGINAL_ARTICLE
Majocchi’s granuloma: A common infection, uncommon for pathologists
https://www.iranjd.ir/article_98298_c505749832edc60e0562ab2fb33540e1.pdf
2016-10-01
142
143
Beniwal
Kalpana
1
LEAD_AUTHOR
Duhan
Amrita
2
AUTHOR