TY - JOUR ID - 120833 TI - A comparison of the efficacy of 50% trichloroacetic acid (TCA) application and dermabrasion in patients with idiopathic guttate hypomelanosis (IGH): a pilot study JO - Iranian Journal of Dermatology JA - IJD LA - en SN - AU - P. Dhotre, Amruta AU - P. Singh, Sudhir AU - Madke, Bhushan AU - Singh, Adarshlata AU - Jawade, Sugat AD - Jawaharlal Nehru Medical College, Sawangi, Wardha, Maharashtra, India AD - Department of Dermatology, Datta Meghe Medical College, Nagpur, Maharashtra, India AD - Department of Dermatology, Jawaharlal Nehru Medical College, Sawangi, Wardha, Maharashtra, India Y1 - 2020 PY - 2020 VL - 23 IS - 4 SP - 142 EP - 149 KW - hypomelanosis KW - dermabrasion KW - Wound KW - trichloroacetic acid DO - 10.22034/ijd.2020.120833 N2 - Background: Idiopathic guttate hypomelanosis (IGH) is characterized by discrete, multiple, round-to-oval hypopigmented macules of approximately 2-5 mm diameter, especially on the forearms and pretibial area,which increase in number with aging. Recent focus has been on therapeutic wounding, which stimulates melanocytes from the periphery and surrounding hair follicles to proliferate, migrate, and repigment the lesions. This study aimed to evaluate and compare the efficacy of trichloroacetic (TCA) 50% application and dermabrasion in IGH patients.Methods: Twenty patients of IGH were enrolled after considering various inclusion and exclusion criteria. IGH lesions over the right side were treated with trichloroacetic acid (TCA) 50% witha cotton-tipped applicator. IGH lesions over the left side were treated with dermabrasion.Results: Of the 153 macules in 20 patients, all 81 macules in the dermabrasion group showed some repigmentation, whereas 7 (9.7%) out of 72 macules treated with 50% TCA Touch™ showedno improvement. At the end of 3 months, repigmentation up to 25%, between 25–50%, and between 51–75% was seen in 18.5%, 66.7%, and 14.8% of lesions treated with dermabrasion, respectively. This is while TCA 50% touch-treated macules showed up to 25% and between 25–50% repigmentation in 48.6% and 41.7% of instances, respectively.Conclusion: The analysis suggested that both dermabrasion and TCA 50% Touch are effective in the treatment of IGH. Dermabrasion proved to be more effective than TCA peel and can be tried before or with the medical line of therapy in the treatment of IGH.  UR - https://www.iranjd.ir/article_120833.html L1 - https://www.iranjd.ir/article_120833_11cee557bab92e9d04464934af09d134.pdf ER -