TY - JOUR ID - 98436 TI - Langerhans cell Histiocytosis: Report of a case with cutaneous lesions with favorable response to oral Thalidomide JO - Iranian Journal of Dermatology JA - IJD LA - en SN - AU - Mortazavi, H AU - Ehsani, AH AU - Safaei Naraghi, Z AU - Asgari, M AD - Y1 - 2001 PY - 2001 VL - 4 IS - 4 SP - 34 EP - 40 KW - langerhans cell histiocytosis KW - Thalidomide KW - Birbeck granule DO - N2 - We report of a 29-year-old man presented with yellow-red, scaling papules on the skin of scalp, retro-auricular folds, inguinal, axillary, chest and abdomen. The lesions had a poikilodermatious appearance in some areas, such as trunk. The patient also had diabetes insipidus and skull osteolytic lesions. The diagnosis of langerhans cell histiocytosis (LCH) was suggested based on H and E staining of skin biopsy specimen. S-100 staining was positive in immunohistochemistry. Birbeck granules were seen in electron microscopic examination confirming the diagnosis of LCH. Considering the systemic involvement, he is a case of an extensive LCH in new classification and a case of Hand-Schuller-Christian in the old classification. The cutaneous lesions of the patients responded to oral thalidomide 200 mg daily after 2 months and did not recur after 6 months follow up. UR - https://www.iranjd.ir/article_98436.html L1 - https://www.iranjd.ir/article_98436_ad805c5f91943222eb703fa5813ce22c.pdf ER -