2024-03-29T18:20:10Z
https://www.iranjd.ir/?_action=export&rf=summon&issue=13351
Iranian Journal of Dermatology
Iran J Dermatol
2003
6
3
HLA-B5 antigen in Iranian patients with Behcet’s disease: A case-control study
H
Pourmoghim
Gh.H
Ghaffarpour
J
Malboobi
Background: The strong association of Behcet’s disease with HLA-B5 antigen has been observed in several ethnic groups from Middle East to Far East. Objective: To evaluate the frequency and association of HLA-B5 and also likelihood ratio of involvement in Behcet’s disease in a group of Iranian patients. Patients and Methods: HLA-B5 antigen typing was performed by serologic method in 56 patients with Behcet’s disease (Diagnosed by International Study Group Criteria) and 71 cases with seronegative diseases as control group. The difference in frequency and association between HLA-B5 antigen and Behcet’s disease was evaluated by chi-square test and phi-test. Results: The phenotype frequencies of HLA-B5 antigen in Behcet’s disease patients and control group were 66% and 26% respectively (X=19.62, P=0.0001). The association of HLA-B5 antigen phenotype with Behcet’s disease was strong (Phi=0.39, P=0.0001). The likelihood ratio was 20:1 for HLA-B5 antigen positivity and Behcet’s disease. Gene frequency of HLA-B5 was 46% in Behcet’s disease patients and 14% in control group. Conclusion: This study revealed a strong association of HLA-B5 antigen with Behcet’s disease in Iranian patients.
Behcet’s disease
HLA-B5 antigen
association
2003
04
01
4
7
https://www.iranjd.ir/article_98474_8b743b8bac324c8d3f49c38e1a17fb1d.pdf
Iranian Journal of Dermatology
Iran J Dermatol
2003
6
3
The efficacy of topical Sucralfate in comparison with Hydrocortisone cream in the treatment of Diaper dermatitis: A randomized, double blind clinical trial
F
Iraji
M
Rezazadeh
Background: Topical corticosteroids are currently used for treatment of diaper dermatitis. Previous studies have shown the efficacy of sucralfate in the treatment of diaper dermatitis and contact dermatitis in peri-stomy areas. Objectives: To evaluate the efficacy of topical sucralfate in comparison with hydrocortisone cream in the treatment of diaper dermatitis. Patients and Methods: In a double-blind, randomized clinical trial, 64 patients with diaper dermatitis were treated with sucralfate cream 4% or hydrocortisone cream. The duration of treatment was 8 weeks and patients were evaluated every two weeks until complete healing. The results were evaluated with chi-square test. Results: Complete healing (More than 50% improvement) occurred in 90.6% and partial healing (20-50% improvement) in 9.4% of patients in each group (P>0.05). Conclusion: Topical sucralfate is an effective, available and cheap therapeutic intervention for diaper dermatitis, which has equal efficacy with topical hydrocortisone cream.
diaper dermatitis
sucralfate
Hydrocortisone
2003
04
01
8
12
https://www.iranjd.ir/article_98475_1d3f8db81885c411290138ff33b13576.pdf
Iranian Journal of Dermatology
Iran J Dermatol
2003
6
3
Frequency of depression in patients suffering from Vitiligo
I
Esfandiar Pour
P
Afshar Zadeh
Background: Some skin diseases cause severe stress in patients and relieving these stresses greatly helps to treat the underlying disease and to prevent the recrudescence of it. Objectives: To determine the frequency of depression in patients suffering from vitiligo. Patients and Methods: 120 patients with a clinical diagnosis of vitiligo referred to dermatologic clinics in Kerman from 1380 to 1381 were studied. The impression of vitiligo was made according to clinical interview and physical examination. After filling the questionnaire the patients were referred to psychiatric clinic to fill in the Hamilton questionnaire. Results: 120 patients included 74 women (61.6%) and 46 men (38.4%) with mean age of 23±13 years. 30.83% (37 patients) had no depressive disorder, 38.34% (46 patients) had depressed mood and 30.83% (37 patients) had major depressive disorder. From 37 patients with major depressive disorder, 27 patients (73%) were female and 10 patients (27%) were male (P<0.001). Conclusion: Any clinical intervention that reduces the extension and visibility of depigmentation will have psychologic benefit. It may be important to recognize and deal with the social and psychologic consequences of the disease.
Vitiligo
depression
Depressed mood
2003
04
01
13
18
https://www.iranjd.ir/article_101083_cbf87e71b7c1659a6ea4e97cff2e8260.pdf
Iranian Journal of Dermatology
Iran J Dermatol
2003
6
3
Frequency of depression and anxiety disorders in Psoriatic patients
Sh
Enshaieh
A
Kiani
A
Yazdani
Background: It seems that psychological factors have important role in beginning or exacerbation of psoriasis. On the other hand, psoriasis negatively impacts quality of lives of the patients. Objective: To determine the frequency of depression and anxiety disorders in psoriatic patients. Patients and Methods: In this descriptive study we evaluated 83 psoriatic patients referred to dermatologic clinics in Isfahan from 1379 to 1380. Beck and zoonge questionnaires were completed by the patients to evaluate depression and anxiety, respectively. Analysis of data was done by SPSS program with 95% confidence interval. Results: The frequency of depression in the patients was 69.9%. The most common type of depression was “Relative depression” (26.5%). The frequency of anxiety in psoriatic patients was 20.5%. These figures are higher than that reported in general population in Isfahan. Conclusion: The frequencies of depression and anxiety disorders in psoriatic patients were higher than general population. There was a direct correlation between the duration of disease and the prevalence of depression and anxiety disorders.
Psoriasis
depression
Anxiety
2003
04
01
19
23
https://www.iranjd.ir/article_98476_98dcf8f72ee6d2b2cf06b05b5f577683.pdf
Iranian Journal of Dermatology
Iran J Dermatol
2003
6
3
Cutaneous manifestations in HIV seropositive male prisoners in Kermanshah
N
Esmaeili
M
Safaei Pourzamani
F
Rahimi
Background: To get accustomed with cutaneous manifestations related to AIDS is effective in early diagnosis of this disease. Objective: To evaluate the cutaneous manifestations in HIV seropositive patients. Patients and Methods: A prospective, descriptive and cross-sectional study was performed on HIV-positive male prisoners in Kermanshah central prison and in addiction camp, referred to skin disease center of Kermanshah University, during eleven months; and their cutaneous manifestations were analyzed. Results: 43 out of 79 patients (54.4%) had mucocutaneous manifestations. 26 patients (32.9%) had herpes zoster infection. Two patients (4.6%) developed recurrent herpes zoster and five patients (11.6%) showed wide scar in low back area and shoulder because of previous herpes zoster. Other manifestations included acne (23.3%), generalized pruritus (11.6%) and oral herpes simplex infection, scabies and tinea versicolor in few cases. The majority of patients (32.6%) were in the age group of 30-34 years. Conclusion: The most common cutaneous disease in this study was herpes zoster. Herpes zoster infection in patients without any obvious risk factor could be a predictor of probable HIV infection.
Cutaneous manifestations
Virus
herpes zoster
2003
04
01
24
26
https://www.iranjd.ir/article_98477_80bd4197aea99ab08d11e732f2fa9082.pdf
Iranian Journal of Dermatology
Iran J Dermatol
2003
6
3
Hypertrophic scars and Keloids
H
Ansarin
A
Ghahhari
SF
Akbarian
The available treatment modalities for hypertrophic scars and keloids have very little success. Surgical treatment of these lesions without adjuvant therapy is also associated with high recurrence rate. Hypertrophic scars and keloids are the results of a series of cellular and molecular changes which their identification can guide us toward new treatment modalities which may decrease the pathological factors, or help balancing the repair mechanism; thus inhibiting extensive scar formation. In this article, we have reviewed the latest treatment methods, as well as molecular and cellular reactions, which lead to the formation of hypertrophic scars and keloids.
Scar
keloid
treatment
Pathogenesis
2003
04
01
27
34
https://www.iranjd.ir/article_101084_deae405775b4974e531a4011f0ad5bd4.pdf
Iranian Journal of Dermatology
Iran J Dermatol
2003
6
3
Deep dermatophytosis in a patient with Rheumatoid Arthritis on immunosuppressive drugs: A case report
N
Alizadeh
Sh
Sadr Ashkevari
J
Golchai
AA
Fallahi
Dermatophyte infections are one of the most common superficial fungal infections. However dermatophytes invade subcutaneous tissues rarely. We report herein a 65 year-old woman who was as a known case of rheumatoid arthritis (For 10 years) and taking immunosuppressive drugs, presented with multiple nodules and sinuses in the knee area. Histopathologic studies revealed PAS positive granulomas and fungal culture confirmed Trichophyton rubrum infection.
Deep dermatophytosis
Rheumatoid arthritis
immunosuppressive drugs
2003
04
01
35
38
https://www.iranjd.ir/article_98478_7ddb4585ab635608659de8c96c716099.pdf
Iranian Journal of Dermatology
Iran J Dermatol
2003
6
3
Squamous cell carcinoma arising from chronic hypertrophic Lichen Planus: A case report
R
Yaghoobi
N
Sina
K
Saedi
Association of lichen planus and cutaneous malignancies is rare. Reports of neoplastic changes are mostly related to buccal chronic erosive lichen planus. We report herein a 29-year-old man who developed squamous cell carcinoma on previous lesions of chronic hypertrophic lichen planus of lower legs. Careful follow up of patients with chronic lichen planus and biopsy sampling of uncommon lesions is required to rule out malignant transformation.
Lichen Planus
Squamous Cell Carcinoma
Malignancy
2003
04
01
39
43
https://www.iranjd.ir/article_98479_889e7777a6043b4042a4dec6de0ecc32.pdf